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> Protein (NX_Q96SQ5)
Protein (NX_Q96SQ5)
Protein
Gene SymbolZNF587 to neXtProt (NX_Q96SQ5)
DescriptionZinc finger protein 587
Chromosome19
Location19q13.43 (58361225 ~ 58376480) to Ensembl
Sequene Features : Isoforms 2, Variants 54, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01transcript level
2 54 0
2014-09-19transcript level
2 46 0
2014-05-27transcript level
2 46 0
2014-02-25transcript level
2 46 0
2013-12-09transcript level
2 40 0
2013-11-01transcript level
2 40 0
2013-09-12transcript level
2 40 0
2013-08-17transcript level
2 40 0
2013-07-15transcript level
1 25 0
2013-06-11transcript level
1 25 0
2013-02-12transcript level
1 16 0
2012-12-20transcript level
1 16 0
2012-10-30transcript level
1 17 0
2012-10-07transcript level
1 17 0
2012-08-24transcript level
1 17 0
2012-07-28transcript level
1 17 0
2012-06-08transcript level
1 17 0
2012-05-07transcript level
1 15 0
2012-04-10transcript level
1 15 0
2012-01-13transcript level
1 8 0
2011-12-20transcript level
1 8 0
2011-11-11transcript level
1 8 0
2011-08-23transcript level
1 8 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q96SQ5-1
0 6 25 65579.6083
NX_Q96SQ5-2
1 6 24 65451.5501
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-6427977,EBI-5661036 FSD2  
  .N/A .N/A .N/A
2 EBI-6427977,EBI-740019 PLSCR1  
  .positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity
.regulation of Fc receptor mediated stimulatory signaling pathway
.defense response to virus
  + 11 more...
.CD4 receptor binding
.enzyme binding
.phospholipid scramblase activity
  + 5 more...
.extracellular exosome
.membrane raft
.extracellular matrix
  + 7 more...
3 EBI-6427977,EBI-742487 SPRY2  
  .positive regulation of protein serine/threonine kinase activity
.positive regulation of ERK1 and ERK2 cascade
.negative regulation of ERK1 and ERK2 cascade
  + 19 more...
.protein serine/threonine kinase activator activity
.protein serine/threonine kinase inhibitor activity
.protein kinase binding
.ruffle membrane
.microtubule cytoskeleton
.plasma membrane
  + 2 more...
4 EBI-6427977,EBI-714135 STX11  
  .membrane fusion
.vesicle docking
.natural killer cell degranulation
  + 4 more...
.SNAP receptor activity
.SNARE binding
.SNARE complex
.integral component of membrane
.endomembrane system
  + 3 more...
5 EBI-6427977,EBI-1047263 KRT38  
  .N/A .structural molecule activity .extracellular exosome
.intermediate filament
6 EBI-6427977,EBI-10196781 KRTAP2-3  
  .N/A .N/A .keratin filament
7 EBI-6427977,EBI-533224 TCF4  
  .protein-DNA complex assembly
.positive regulation of transcription from RNA polymerase II promoter
.positive regulation of transcription, DNA-templated
  + 3 more...
.E-box binding
.protein heterodimerization activity
.bHLH transcription factor binding
  + 9 more...
.transcription factor complex
.nucleus
8 EBI-6427977,EBI-3958099 KRTAP5-9  
  .epidermis development .N/A .keratin filament
9 EBI-6427977,EBI-10172150 KRTAP10-5  
  .N/A .identical protein binding .keratin filament
10 EBI-6427977,EBI-10172290 KRTAP10-7  
  .N/A .identical protein binding .keratin filament
11 EBI-6427977,EBI-10171774 KRTAP10-8  
  .N/A .N/A .keratin filament
12 EBI-6427977,EBI-10172052 KRTAP10-9  
  .N/A .N/A .keratin filament
13 EBI-6427977,EBI-618309 GOLGA2  
  .negative regulation of protein binding
.mitotic cell cycle
.syntaxin binding
.protein kinase binding
.Golgi cisterna membrane
.ER to Golgi transport vesicle
.cis-Golgi network
  + 4 more...
14 EBI-6427977,EBI-359224 TRAF1  
  .regulation of extrinsic apoptotic signaling pathway
.positive regulation of NF-kappaB transcription factor activity
.signal transduction
  + 2 more...
.thioesterase binding
.ubiquitin protein ligase binding
.zinc ion binding
.tumor necrosis factor receptor binding
.cytoplasm
15 EBI-6427977,EBI-747225 RUNDC3A  
  .small GTPase mediated signal transduction .GTPase regulator activity
.guanylate cyclase activator activity
.plasma membrane
.cytosol
16 EBI-6427977,EBI-742948 MTUS2  
  .N/A .protein homodimerization activity
.microtubule binding
.microtubule
.cytoplasm
.nucleus
17 EBI-6427977,EBI-949753 TENC1  
  .multicellular organismal homeostasis
.intracellular signal transduction
.multicellular organism growth
  + 5 more...
.metal ion binding
.kinase binding
.phosphoprotein phosphatase activity
.focal adhesion
.plasma membrane
18 EBI-6427977,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
19 EBI-6427977,EBI-2549423 HMBOX1  
  .positive regulation of transcription, DNA-templated
.negative regulation of transcription, DNA-templated
.transcription, DNA-templated
.DNA binding .cytoplasm
.nucleoplasm
.nucleus
20 EBI-6427977,EBI-10173507 ADAMTSL4  
  .cellular protein metabolic process
.post-translational protein modification
.positive regulation of apoptotic process
  + 4 more...
.metalloendopeptidase activity
.protease binding
.endoplasmic reticulum lumen
.interstitial matrix
21 EBI-6427977,EBI-945833 NOTCH2NL  
  .cell differentiation
.multicellular organismal development
.Notch signaling pathway
.calcium ion binding .cytoplasm
.extracellular region
22 EBI-6427977,EBI-739624 CEP70  
  .organelle organization
.mitotic cell cycle
.G2/M transition of mitotic cell cycle
.N/A .nuclear membrane
.cytosol
.centrosome
  + 2 more...
23 EBI-6427977,EBI-740727 ZNF417  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
24 EBI-6427977,EBI-725997 TRIM41  
  .protein ubiquitination .ligase activity
.zinc ion binding
.cytoplasm
.nucleolus
25 EBI-6427977,EBI-742740 ZBTB8A  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
26 EBI-6427977,EBI-10171416 CCDC136  
  .N/A .N/A .integral component of membrane
.mitochondrion
27 EBI-6427977,EBI-4311573 CSRNP1  
  .face morphogenesis
.palate development
.skeletal system morphogenesis
  + 4 more...
.sequence-specific DNA binding
.sequence-specific DNA binding transcription factor activity
.RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.nucleus
28 EBI-6427977,EBI-724076 MDFI  
  .trophoblast giant cell differentiation
.embryonic skeletal system morphogenesis
.negative regulation of DNA binding
  + 6 more...
.N/A .cytoplasm
.nucleus
29 EBI-6427977,EBI-2130429 TRIM54  
  .cell differentiation
.multicellular organismal development
.signal transduction
  + 2 more...
.zinc ion binding
.signal transducer activity
.Z disc
.microtubule associated complex
.microtubule
30 EBI-6427977,EBI-744794 TSGA10  
  .cell projection assembly
.spermatogenesis
.N/A .neuron projection
.nuclear membrane
.motile cilium
.cytoplasm
31 EBI-6427977,EBI-744115 CEP44  
  .N/A .N/A .midbody
.centrosome
.cytoplasm
.spindle pole
32 EBI-6427977,EBI-751319 CARD9  
  .nucleotide-binding oligomerization domain containing signaling pathway
.defense response to virus
.defense response to Gram-positive bacterium
  + 17 more...
.CARD domain binding
.protein homodimerization activity
.plasma membrane
.cytosol
.cytoplasm
33 EBI-6427977,EBI-349832 GOPC  
  .protein homooligomerization
.regulation of catalytic activity
.apical protein localization
  + 6 more...
.ion channel binding .postsynaptic membrane
.protein complex
.Golgi-associated vesicle membrane
  + 9 more...
34 EBI-6427977,EBI-2341518 TRIM36  
  .regulation of cell cycle
.acrosome reaction
.ligase activity
.zinc ion binding
.ubiquitin-protein transferase activity
.extracellular exosome
.cytoskeleton
.acrosomal vesicle
35 EBI-6427977,EBI-10172526 MID2  
  .negative regulation of viral release from host cell
.positive regulation of NF-kappaB transcription factor activity
.positive regulation of sequence-specific DNA binding transcription factor activity
  + 6 more...
.phosphoprotein binding
.protein heterodimerization activity
.protein homodimerization activity
  + 3 more...
.extracellular exosome
.microtubule
.cytoplasm
36 EBI-6427977,EBI-302355 PNMA2  
  .positive regulation of apoptotic process .N/A .nucleolus
37 EBI-6427977,EBI-2212028 SSX2IP  
  .regulation of cell motility
.centrosome organization
.cilium assembly
  + 3 more...
.N/A .protein complex
.ciliary basal body
.centriolar satellite
  + 3 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
ascites25
bladder133
blood8
brain7
intestine17
kidney4
liver9
lung8
mammary gland6
skin4
testis4
thyroid21
trachea19
uterus8
Health State
TissuesTPM*
normal23
bladder carcinoma170
breast (mammary gland) tumor182
colorectal tumor53
gastrointestinal tumor67
germ cell tumor7
glioma18
head and neck tumor37
kidney tumor14
leukemia10
lung tumor19
lymphoma27
non-neoplasia10
ovarian tumor39
primitive neuroectodermal tumor of the CNS31
prostate cancer19
retinoblastoma21
skin tumor7
uterine tumor22
Developmental Stage
TissuesTPM*
adult39
embryoid body42
blastocyst16
neonate32
fetus30
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue4.2
adrenal gland4.9
appendix8.5
bone marrow6.6
cerebral cortex6.6
colon9.7
duodenum10.6
esophagus4.1
gallbladder6.6
heart muscle4.4
kidney4.5
liver2.6
lung5.3
lymph node7.5
ovary7
pancreas2.7
placenta7.3
prostate9.6
salivary gland6.7
skin6.5
small intestine8.7
spleen7.7
stomach12.5
testis5.9
thyroid gland6.9
urinary bladder7.5
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected


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