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> Protein (NX_Q96T49)
Protein (NX_Q96T49)
Protein
Gene SymbolPPP1R16B to neXtProt (NX_Q96T49)
DescriptionProtein phosphatase 1 regulatory inhibitor subunit 16B
Chromosome20
Location20q11.23 (37434348 ~ 37551667) to Ensembl
Sequene Features : Isoforms 2, Variants 105, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
.negative regulation of peptidyl-serine dephosphorylation
.establishment of endothelial barrier
  + 6 more...
.protein phosphatase type 1 regulator activity .perinuclear region of cytoplasm
.cell projection
.plasma membrane
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 105 3
2014-09-19protein level
2 78 3
2014-05-27protein level
2 78 3
2014-02-25protein level
2 76 3
2013-12-09protein level
2 73 3
2013-11-01protein level
2 68 3
2013-09-12protein level
2 68 3
2013-08-17protein level
2 68 3
2013-07-15protein level
1 46 3
2013-06-11protein level
1 46 3
2013-02-12protein level
1 11 5
2012-12-20protein level
1 11 5
2012-10-30protein level
1 11 5
2012-10-07protein level
1 11 5
2012-08-24protein level
1 10 5
2012-07-28protein level
1 10 5
2012-06-08protein level
1 10 5
2012-05-07protein level
1 5 5
2012-04-10protein level
1 5 5
2012-01-13protein level
1 3 5
2011-12-20protein level
1 3 5
2011-11-11protein level
1 3 5
2011-08-23protein level
1 3 5
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q96T49-1
3 19 0 63510.8447
NX_Q96T49-2
1 19 0 58862.5062
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-10293968,EBI-748171 CRX  
  .retina development in camera-type eye
.response to stimulus
.positive regulation of photoreceptor cell differentiation
  + 5 more...
.leucine zipper domain binding
.nuclear hormone receptor binding
.sequence-specific DNA binding transcription factor activity
  + 3 more...
.transcription factor complex
.nucleus
2 EBI-10293968,EBI-742268 TADA2A  
  .histone H3 acetylation
.transcription from RNA polymerase II promoter
.regulation of transcription from RNA polymerase II promoter
.chromatin organization
.zinc ion binding
.transcription cofactor activity
.sequence-specific DNA binding transcription factor activity
  + 2 more...
.chromosome
.nucleus
.PCAF complex
3 EBI-10293968,EBI-618309 GOLGA2  
  .negative regulation of protein binding
.mitotic cell cycle
.syntaxin binding
.protein kinase binding
.Golgi cisterna membrane
.ER to Golgi transport vesicle
.cis-Golgi network
  + 4 more...
4 EBI-10293968,EBI-348469 SF3B4  
  .positive regulation of mRNA splicing, via spliceosome
.gene expression
.RNA splicing
  + 3 more...
.poly(A) RNA binding
.nucleotide binding
.U12-type spliceosomal complex
.spliceosomal complex
.nucleoplasm
5 EBI-10293968,EBI-10172380 FAM208B  
  .N/A .N/A .cytoplasm
.nucleoplasm
.nucleus
6 EBI-10293968,EBI-4397613 KCTD9  
  .protein homooligomerization .N/A .N/A
7 EBI-10293968,EBI-713786 PHC2  
  .cellular protein metabolic process
.post-translational protein modification
.protein sumoylation
  + 2 more...
.identical protein binding
.zinc ion binding
.DNA binding
.PRC1 complex
.PcG protein complex
.nucleoplasm
  + 2 more...
8 EBI-10293968,EBI-739624 CEP70  
  .organelle organization
.mitotic cell cycle
.G2/M transition of mitotic cell cycle
.N/A .nuclear membrane
.cytosol
.centrosome
  + 2 more...
9 EBI-10293968,EBI-5278764 CDCA7L  
  .positive regulation of cell proliferation
.regulation of transcription, DNA-templated
.transcription, DNA-templated
.N/A .cytoplasm
.nucleolus
.nucleus
10 EBI-10293968,EBI-747204 IKZF3  
  .regulation of lymphocyte differentiation
.regulation of B cell differentiation
.regulation of apoptotic process
  + 5 more...
.protein heterodimerization activity
.metal ion binding
.sequence-specific DNA binding
  + 2 more...
.plasma membrane
.cytoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
bladder33
blood40
bone27
bone marrow20
brain81
connective tissue20
embryonic tissue9
heart44
intestine4
kidney66
lung38
lymph361
lymph node590
mammary gland119
ovary9
pancreas28
pharynx98
placenta7
prostate10
spleen112
stomach10
testis9
thymus50
thyroid42
tonsil411
trachea19
uterus17
vascular19
Health State
TissuesTPM*
normal66
bladder carcinoma56
chondrosarcoma48
gastrointestinal tumor8
germ cell tumor7
glioma83
head and neck tumor14
leukemia10
lung tumor38
lymphoma263
non-neoplasia41
pancreatic tumor9
primitive neuroectodermal tumor of the CNS47
prostate cancer19
uterine tumor11
Developmental Stage
TissuesTPM*
adult38
blastocyst32
fetus32
infant42
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue11.8
adrenal gland2.9
appendix18.7
bone marrow12
cerebral cortex28.1
colon5.1
duodenum3.3
esophagus9.1
gallbladder11.4
heart muscle5.8
kidney24.2
liver1.8
lung11.2
lymph node42.2
ovary1.4
placenta3.2
prostate1.2
salivary gland1.5
skin2.5
small intestine5.6
spleen16
stomach6.3
testis1.7
thyroid gland4
urinary bladder18.5
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*613275, gene) Protein phosphatase 1, regulatory subunit 16b; PPP1R16BOMIM


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