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> Protein (NX_Q96T58)
Protein (NX_Q96T58)
Protein
Gene SymbolSPEN to neXtProt (NX_Q96T58)
DescriptionMsx2-interacting protein
Chromosome1
Location1p36.13 (16174359 ~ 16266955) to Ensembl
Sequene Features : Isoforms 1, Variants 447, PTMs 64 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of neurogenesis
.positive regulation of transcription, DNA-templated
.negative regulation of transcription, DNA-templated
  + 3 more...
.poly(A) RNA binding
.transcription corepressor activity
.sequence-specific DNA binding transcription factor activity
  + 4 more...
.extracellular exosome
.transcriptional repressor complex
.nucleoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 447 64
2014-09-19protein level
1 335 65
2014-05-27protein level
1 335 66
2014-02-25protein level
1 333 63
2013-12-09protein level
1 260 63
2013-11-01protein level
1 243 53
2013-09-12protein level
1 243 53
2013-08-17protein level
1 243 53
2013-07-15protein level
1 176 53
2013-06-11protein level
1 176 53
2013-02-12protein level
1 89 58
2012-12-20protein level
1 89 58
2012-10-30protein level
1 102 58
2012-10-07protein level
1 102 58
2012-08-24protein level
1 98 58
2012-07-28protein level
1 98 58
2012-06-08protein level
1 102 58
2012-05-07protein level
1 70 58
2012-04-10protein level
1 70 58
2012-01-13protein level
1 46 58
2011-12-20protein level
1 46 58
2011-11-11protein level
1 46 54
2011-08-23protein level
1 46 54
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q96T58-1
153 0 0 402002.6643
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-765739,EBI-389883 NCK1  
  .negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
.negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
.negative regulation of PERK-mediated unfolded protein response
  + 23 more...
.eukaryotic initiation factor eIF2 binding
.receptor tyrosine kinase binding
.protein binding, bridging
  + 5 more...
.vesicle membrane
.cell-cell junction
.plasma membrane
  + 6 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites25
bladder33
blood57
bone153
bone marrow61
brain30
connective tissue33
embryonic tissue79
eye67
heart33
intestine81
kidney37
liver68
lung53
lymph45
lymph node367
mammary gland125
mouth60
muscle65
nerve257
ovary39
pancreas28
parathyroid48
pharynx49
placenta31
prostate58
skin18
stomach94
testis16
thyroid128
uterus43
vascular38
Health State
TissuesTPM*
normal72
bladder carcinoma56
breast (mammary gland) tumor96
chondrosarcoma72
colorectal tumor62
gastrointestinal tumor67
germ cell tumor22
glioma27
head and neck tumor67
kidney tumor58
leukemia95
liver tumor41
lung tumor19
lymphoma27
non-neoplasia41
ovarian tumor26
pancreatic tumor28
primitive neuroectodermal tumor of the CNS31
prostate cancer28
retinoblastoma21
skin tumor15
soft tissue/muscle tissue tumor23
uterine tumor44
Developmental Stage
TissuesTPM*
adult85
embryoid body114
blastocyst65
neonate64
fetus114
infant42
juvenile89
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue15.7
adrenal gland11.8
appendix17.6
bone marrow23.5
cerebral cortex12.8
colon13.7
duodenum10.7
esophagus14.2
gallbladder12.1
heart muscle9.3
kidney14.7
liver9.2
lung15.1
lymph node17.7
ovary27.5
pancreas11.3
placenta15.9
prostate11.5
salivary gland12.1
skin21.2
small intestine10.8
spleen19.7
stomach12.4
testis14.7
thyroid gland16.8
urinary bladder11.8
Tissues
TissuesExpression level
adrenal glandHigh
appendixHigh
bone marrowHigh
breastMedium
bronchusHigh
cerebellumHigh
cerebral cortexHigh
cervix, uterineHigh
colonHigh
duodenumMedium
endometrium 1Medium
endometrium 2Medium
epididymisHigh
esophagusHigh
fallopian tubeMedium
gallbladderHigh
heart muscleHigh
hippocampusHigh
kidneyHigh
lateral ventricleHigh
liverMedium
lungHigh
lymph nodeMedium
nasopharynxHigh
oral mucosaHigh
ovaryMedium
pancreasHigh
parathyroid glandHigh
placentaHigh
prostateHigh
rectumHigh
salivary glandMedium
seminal vesicleMedium
skeletal muscleMedium
skin 2High
small intestineMedium
smooth muscleHigh
soft tissue 1Medium
soft tissue 2High
spleenMedium
stomach 1High
stomach 2High
testisHigh
thyroid glandHigh
tonsilHigh
urinary bladderHigh
vaginaHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*613484, gene) Spen, drosophila, homolog of; SPENOMIM


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