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> Protein (NX_Q99062)
Protein (NX_Q99062)
Protein
Gene SymbolCSF3R to neXtProt (NX_Q99062)
DescriptionGranulocyte colony-stimulating factor receptor
Chromosome1
Location1p34.3 (36931644 ~ 36948879) to Ensembl
Sequene Features : Isoforms 4, Variants 122, PTMs 15 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.amelogenesis
.neutrophil chemotaxis
.signal transduction
  + 2 more...
.cytokine receptor activity
.receptor activity
.integral component of plasma membrane
.extracellular region
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
4 122 15
2014-09-19protein level
4 93 15
2014-05-27protein level
4 93 15
2014-02-25protein level
4 92 15
2013-12-09protein level
4 71 15
2013-11-01protein level
4 69 15
2013-09-12protein level
4 69 15
2013-08-17protein level
4 69 15
2013-07-15protein level
4 55 15
2013-06-11protein level
4 55 15
2013-02-12protein level
4 31 60
2012-12-20protein level
4 31 60
2012-10-30protein level
4 38 60
2012-10-07protein level
4 38 15
2012-08-24protein level
4 28 15
2012-07-28protein level
4 28 15
2012-06-08protein level
4 10 15
2012-05-07protein level
4 10 15
2012-04-10protein level
4 10 15
2012-01-13protein level
4 10 15
2011-12-20protein level
4 10 15
2011-11-11protein level
4 10 15
2011-08-23protein level
4 10 15
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q99062-1
0 25 0 92096.9177
NX_Q99062-2
9 17 0 85065.2646
NX_Q99062-3
3 24 0 95052.3688
NX_Q99062-4
2 21 0 86553.2456
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-7331284,EBI-3390054 UBC  
  .programmed necrotic cell death
.apoptotic signaling pathway
.energy homeostasis
  + 90 more...
.poly(A) RNA binding
.protease binding
.extracellular exosome
.endocytic vesicle membrane
.endosome membrane
  + 3 more...
2 EBI-7331284,EBI-518675 STAT3  
  .negative regulation of neuron migration
.interleukin-6-mediated signaling pathway
.JAK-STAT cascade involved in growth hormone signaling pathway
  + 35 more...
.protein dimerization activity
.transcription regulatory region DNA binding
.protein phosphatase binding
  + 9 more...
.plasma membrane
.cytosol
.mitochondrial inner membrane
  + 4 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
blood662
bone marrow61
brain7
connective tissue6
embryonic tissue4
eye4
intestine30
liver19
lung23
mammary gland6
muscle9
nerve64
ovary39
pancreas4
placenta671
prostate10
spleen131
stomach31
testis4
vascular38
Health State
TissuesTPM*
normal72
colorectal tumor53
gastrointestinal tumor8
germ cell tumor7
glioma9
leukemia666
lung tumor48
non-neoplasia20
ovarian tumor39
pancreatic tumor9
Developmental Stage
TissuesTPM*
adult148
fetus19
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue43.3
adrenal gland9.1
appendix226.7
bone marrow347.6
cerebral cortex7
colon4.9
duodenum3.9
esophagus5.8
gallbladder30.8
heart muscle4
kidney1.9
liver8.1
lung81.3
lymph node10.6
ovary1.6
pancreas4.9
placenta163.6
prostate4.1
salivary gland3.3
skin1.3
small intestine8.3
spleen116
stomach4.3
testis2.3
thyroid gland3.6
urinary bladder30.6
Tissues
TissuesExpression level
bone marrowLow
cerebral cortexMedium
heart muscleMedium
lungLow
placentaHigh
skin 1Medium
testisMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*138971, gene) Colony-stimulating factor 3 receptor, granulocyte; CSF3ROMIM
2(#162830, phenotype) Neutrophilia, hereditaryOMIM


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