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> Protein (NX_Q99081)
Protein (NX_Q99081)
Protein
Gene SymbolTCF12 to neXtProt (NX_Q99081)
DescriptionTranscription factor 12
Chromosome15
Location15q21.3 (57210821 ~ 57591479) to Ensembl
Sequene Features : Isoforms 3, Variants 94, PTMs 12 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of transcription from RNA polymerase II promoter
.positive regulation of neuron differentiation
.muscle organ development
  + 2 more...
.E-box binding
.protein heterodimerization activity
.SMAD binding
  + 7 more...
.RNA polymerase II transcription factor complex
.cytoplasm
.nucleus
.nuclear chromatin
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 94 12
2014-09-19protein level
3 77 12
2014-05-27protein level
3 77 12
2014-02-25protein level
3 77 12
2013-12-09protein level
3 65 12
2013-11-01protein level
3 60 12
2013-09-12protein level
3 58 12
2013-08-17protein level
3 58 12
2013-07-15protein level
3 49 9
2013-06-11protein level
3 49 9
2013-02-12protein level
3 26 21
2012-12-20protein level
3 23 21
2012-10-30protein level
3 31 21
2012-10-07protein level
3 31 8
2012-08-24protein level
3 28 8
2012-07-28protein level
3 28 8
2012-06-08protein level
3 18 8
2012-05-07protein level
3 18 8
2012-04-10protein level
3 18 8
2012-01-13protein level
3 8 8
2011-12-20protein level
3 8 8
2011-11-11protein level
3 8 8
2011-08-23protein level
3 8 8
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q99081-1
0 24 2 72920.0952
NX_Q99081-2
2 13 2 55108.3478
NX_Q99081-3
2 23 2 75798.4725
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-722877,EBI-947402 MAPKBP1  
  .N/A .N/A .N/A
2 EBI-722877,EBI-2654687 CRCP  
  .defense response to virus
.innate immune response
.positive regulation of type I interferon production
  + 6 more...
.DNA-directed RNA polymerase activity
.calcitonin gene-related peptide receptor activity
.nucleotide binding
.DNA polymerase III complex
.plasma membrane
.cytosol
  + 3 more...
3 EBI-722877,EBI-1759806 FOXH1  
  .negative regulation of androgen receptor activity
.nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry
.negative regulation of androgen receptor signaling pathway
  + 14 more...
.R-SMAD binding
.co-SMAD binding
.androgen receptor binding
  + 11 more...
.activin responsive factor complex
.transcription factor complex
.nucleoplasm
  + 2 more...
4 EBI-722877,EBI-749295 STK16  
  .cellular response to transforming growth factor beta stimulus
.protein autophosphorylation
.regulation of signal transduction
.ATP binding
.non-membrane spanning protein tyrosine kinase activity
.protein serine/threonine kinase activity
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.perinuclear region of cytoplasm
.membrane
.Golgi-associated vesicle
.cytoplasm
5 EBI-722877,EBI-359352 PSMA1  
  .positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
  + 23 more...
.threonine-type endopeptidase activity
.endopeptidase activity
.RNA binding
.extracellular exosome
.proteasome core complex, alpha-subunit complex
.polysome
  + 7 more...
6 EBI-722877,EBI-750459 SRI  
  .negative regulation of transcription regulatory region DNA binding
.regulation of cell communication by electrical coupling involved in cardiac conduction
.regulation of high voltage-gated calcium channel activity
  + 20 more...
.protein heterodimerization activity
.ion channel binding
.calcium ion binding
  + 4 more...
.extracellular exosome
.dendritic spine neck
.axon terminus
  + 11 more...
7 EBI-722877,EBI-749537 STAT5A  
  .cellular response to granulocyte macrophage colony-stimulating factor stimulus
.positive regulation of mast cell proliferation
.mammary gland epithelium development
  + 45 more...
.signal transducer activity
.sequence-specific DNA binding transcription factor activity
.RNA polymerase II core promoter sequence-specific DNA binding
.cytosol
.nucleoplasm
8 EBI-722877,EBI-711290 CDKN2C  
  .negative regulation of protein serine/threonine kinase activity
.oligodendrocyte differentiation
.negative regulation of phosphorylation
  + 6 more...
.protein kinase binding
.cyclin-dependent protein serine/threonine kinase inhibitor activity
.cytosol
.cytoplasm
.nucleus
9 EBI-722877,EBI-347462 QARS  
  .gene expression
.brain development
.glutaminyl-tRNA aminoacylation
.tRNA aminoacylation for protein translation
.ATP binding
.glutamine-tRNA ligase activity
.cytosol
.mitochondrial matrix
.cytoplasm
10 EBI-722877,EBI-1387094 ID3  
  .regulation of cell cycle
.negative regulation of transcription, DNA-templated
.negative regulation of osteoblast differentiation
  + 17 more...
.transcription corepressor activity
.sequence-specific DNA binding transcription factor activity
.microtubule cytoskeleton
.cytoplasm
.nucleoplasm
.nucleus
11 EBI-722877,EBI-10240074 EDRF1  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.N/A .nucleus
12 EBI-722877,EBI-10254793 ASCL4  
  .skin development
.regulation of transcription from RNA polymerase II promoter
.transcription, DNA-templated
.DNA binding .nucleus
13 EBI-722877,EBI-2341648 TRIM72  
  .protein homooligomerization
.muscle organ development
.exocytosis
  + 2 more...
.zinc ion binding
.phosphatidylserine binding
.sarcolemma
.cytoplasmic vesicle membrane
14 EBI-722877,EBI-1049469 ARMC8  
  .N/A .N/A .N/A
15 EBI-722877,EBI-749051 C6orf165  
  .N/A .N/A .N/A
16 EBI-722877,EBI-10269566 MORN4  
  .N/A .N/A .N/A
17 EBI-722877,EBI-1797313 TWIST2  
  .cornea development in camera-type eye
.face morphogenesis
.embryonic cranial skeleton morphogenesis
  + 10 more...
.sequence-specific DNA binding transcription factor activity
.chromatin binding
.DNA binding
.RNA polymerase II transcription factor binding transcription factor activity
.cytoplasm
.transcription factor complex
.nucleus
18 EBI-722877,EBI-718468 C16orf45  
  .negative regulation of cell motility involved in cerebral cortex radial glia guided migration
.negative regulation of microtubule depolymerization
.N/A .microtubule cytoskeleton
19 EBI-722877,EBI-5460660 HEXIM2  
  .negative regulation of transcription, DNA-templated
.negative regulation of cyclin-dependent protein serine/threonine kinase activity
.transcription, DNA-templated
.negative regulation of transcription from RNA polymerase II promoter
.snRNA binding
.cyclin-dependent protein serine/threonine kinase inhibitor activity
.cytoplasm
.nucleoplasm
.nucleus
20 EBI-722877,EBI-10293291 LYSMD1  
  .N/A .N/A .N/A
21 EBI-722877,EBI-742638 TSNAX  
  .RNA phosphodiester bond hydrolysis, endonucleolytic
.cell differentiation
.protein transport
  + 3 more...
.metal ion binding
.poly(A) RNA binding
.sequence-specific DNA binding
  + 4 more...
.perinuclear region of cytoplasm
.cytosol
.Golgi apparatus
  + 2 more...
22 EBI-722877,EBI-10295883 HOPX  
  .positive regulation of striated muscle cell differentiation
.lung alveolus development
.negative regulation of cell differentiation
  + 8 more...
.DNA binding .nucleus
23 EBI-722877,EBI-8643161 C1orf109  
  .N/A .N/A .N/A
24 EBI-722877,EBI-742688 SPG21  
  .antigen receptor-mediated signaling pathway .CD4 receptor binding .trans-Golgi network transport vesicle
.endosome membrane
.cytosol
  + 3 more...
25 EBI-722877,EBI-372578 NAGK  
  .carbohydrate phosphorylation
.N-acetylneuraminate catabolic process
.N-acetylmannosamine metabolic process
.N-acetylglucosamine metabolic process
.N-acetylglucosamine kinase activity
.N-acylmannosamine kinase activity
.ATP binding
.extracellular exosome
26 EBI-722877,EBI-9057006 OSGIN1  
  .positive regulation of apoptotic process
.negative regulation of cell growth
.cell differentiation
.multicellular organismal development
.growth factor activity .N/A
27 EBI-722877,EBI-10328570 NEUROG3  
  .transdifferentiation
.positive regulation of sequence-specific DNA binding transcription factor activity
.regulation of dendrite morphogenesis
  + 11 more...
.chromatin DNA binding
.transcription coactivator activity
.double-stranded DNA binding
  + 4 more...
.cytoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
bladder100
blood49
bone83
bone marrow61
brain144
cervix123
connective tissue67
ear559
embryonic tissue178
esophagus49
eye119
heart122
intestine64
kidney71
larynx85
liver77
lung71
lymph22
lymph node55
mammary gland79
mouth120
muscle188
ovary68
pancreas56
parathyroid97
pituitary gland60
placenta52
prostate63
skin80
spleen74
stomach62
testis126
thymus250
thyroid171
trachea463
umbilical cord72
uterus168
vascular154
Health State
TissuesTPM*
normal103
bladder carcinoma113
breast (mammary gland) tumor118
cervical tumor144
chondrosarcoma72
colorectal tumor62
esophageal tumor57
gastrointestinal tumor33
germ cell tumor151
glioma167
head and neck tumor127
kidney tumor116
leukemia63
liver tumor72
lung tumor68
lymphoma13
non-neoplasia103
ovarian tumor52
pancreatic tumor28
primitive neuroectodermal tumor of the CNS125
prostate cancer67
retinoblastoma172
skin tumor55
soft tissue/muscle tissue tumor79
uterine tumor77
Developmental Stage
TissuesTPM*
adult89
embryoid body271
blastocyst130
neonate193
fetus156
infant467
juvenile71
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue29.6
adrenal gland23.6
appendix25.2
bone marrow16.8
cerebral cortex64.5
colon27.9
duodenum25.8
esophagus49.1
gallbladder74.8
heart muscle27.4
kidney24.9
liver15.8
lung34.8
lymph node36.5
ovary63
pancreas12.6
placenta31.8
prostate29.4
salivary gland18.8
skin30.2
small intestine27.2
spleen24.9
stomach23.8
testis31
thyroid gland58.9
urinary bladder72.2
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*600480, gene) Transcription factor 12; TCF12OMIM
2extraskeletal myxoid chondrosarcomaCGP


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