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> Protein (NX_Q99259)
Protein (NX_Q99259)
Protein
Gene SymbolGAD1 to neXtProt (NX_Q99259)
DescriptionGlutamate decarboxylase 1
Chromosome2
Location2q31.1 (171669723 ~ 171717661) to Ensembl
Sequene Features : Isoforms 3, Variants 97, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.response to drug
.neurotransmitter biosynthetic process
.protein-pyridoxal-5-phosphate linkage
  + 5 more...
.pyridoxal phosphate binding
.glutamate binding
.glutamate decarboxylase activity
.clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane
.vesicle membrane
.plasma membrane
.intracellular
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 97 1
2014-09-19protein level
3 64 1
2014-05-27protein level
3 64 1
2014-02-25protein level
2 63 1
2013-12-09protein level
2 56 1
2013-11-01protein level
2 53 1
2013-09-12protein level
2 53 1
2013-08-17protein level
2 53 1
2013-07-15protein level
2 42 1
2013-06-11protein level
2 42 1
2013-02-12protein level
2 19 1
2012-12-20protein level
2 18 1
2012-10-30protein level
2 21 1
2012-10-07protein level
2 21 1
2012-08-24protein level
2 21 1
2012-07-28protein level
2 21 1
2012-06-08protein level
2 38 1
2012-05-07protein level
2 31 1
2012-04-10protein level
2 31 1
2012-01-13protein level
2 32 1
2011-12-20protein level
2 32 1
2011-11-11protein level
2 32 1
2011-08-23protein level
2 32 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q99259-1
10 12 1 66853.4404
NX_Q99259-3
1 5 0 25263.4569
NX_Q99259-4
4 12 0 47409.6292
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-743184,EBI-389883 NCK1  
  .negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
.negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
.negative regulation of PERK-mediated unfolded protein response
  + 23 more...
.eukaryotic initiation factor eIF2 binding
.receptor tyrosine kinase binding
.protein binding, bridging
  + 5 more...
.vesicle membrane
.cell-cell junction
.plasma membrane
  + 6 more...
2 EBI-743184,EBI-743215 HAAO  
  .neuron cellular homeostasis
.response to cadmium ion
.small molecule metabolic process
  + 6 more...
.oxygen binding
.electron carrier activity
.ferrous iron binding
.3-hydroxyanthranilate 3,4-dioxygenase activity
.extracellular exosome
.mitochondrial membrane
.cytosol
3 EBI-743184,EBI-992580 STK3  
  .positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
.hepatocyte apoptotic process
.negative regulation of canonical Wnt signaling pathway
  + 25 more...
.protein dimerization activity
.protein serine/threonine kinase activator activity
.ATP binding
  + 4 more...
.cytosol
.cytoplasm
.nucleus
4 EBI-743184,EBI-741181 AGTRAP  
  .regulation of blood pressure
.response to hypoxia
.angiotensin type II receptor activity .intracellular membrane-bounded organelle
.cytoplasmic vesicle membrane
.integral component of membrane
  + 6 more...
5 EBI-743184,EBI-2548702 CMTM5  
  .negative regulation of myoblast differentiation
.chemotaxis
.N/A .integral component of membrane
.extracellular space
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
bone13
brain400
embryonic tissue14
eye43
intestine267
kidney56
larynx127
liver19
mammary gland985
muscle9
ovary19
parathyroid97
placenta183
testis27
thymus25
trachea19
uterus4
Health State
TissuesTPM*
normal185
chondrosarcoma12
colorectal tumor551
germ cell tumor26
glioma37
head and neck tumor22
kidney tumor130
leukemia10
liver tumor31
non-neoplasia51
ovarian tumor26
uterine tumor11
Developmental Stage
TissuesTPM*
adult218
blastocyst48
fetus66
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adrenal gland1.8
bone marrow3.4
cerebral cortex47.3
kidney5.6
prostate1.4
testis3.4
Tissues
TissuesExpression level
cerebellumMedium
cerebral cortexMedium
hippocampusMedium
lateral ventricleMedium
prostateLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#603513, phenotype) Cerebral palsy, spastic quadriplegic, 1; CPSQ1OMIM
2(*605363, gene) Glutamate decarboxylase 1; GAD1OMIM


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