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> Protein (NX_Q99453)
Protein (NX_Q99453)
Protein
Gene SymbolPHOX2B to neXtProt (NX_Q99453)
DescriptionPaired mesoderm homeobox protein 2B
Chromosome4
Location4p13 (41746099 ~ 41750987) to Ensembl
Sequene Features : Isoforms 1, Variants 58, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.neural crest cell migration involved in autonomic nervous system development
.cellular response to BMP stimulus
.dopaminergic neuron differentiation
  + 26 more...
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.RNA polymerase II core promoter proximal region sequence-specific DNA binding
.RNA polymerase II regulatory region sequence-specific DNA binding
.nuclear chromatin
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 58 0
2014-09-19protein level
1 42 0
2014-05-27protein level
1 42 0
2014-02-25protein level
1 42 0
2013-12-09protein level
1 43 0
2013-11-01protein level
1 42 0
2013-09-12protein level
1 42 0
2013-08-17protein level
1 42 0
2013-07-15protein level
1 31 0
2013-06-11protein level
1 31 0
2013-02-12protein level
1 18 0
2012-12-20protein level
1 18 0
2012-10-30protein level
1 18 0
2012-10-07protein level
1 18 0
2012-08-24protein level
1 9 0
2012-07-28protein level
1 9 0
2012-06-08protein level
1 10 0
2012-05-07protein level
1 10 0
2012-04-10protein level
1 10 0
2012-01-13protein level
1 12 0
2011-12-20protein level
1 12 0
2011-11-11protein level
1 12 0
2011-08-23protein level
1 12 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q99453-1
7 0 3 31601.2976
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
brain2
embryonic tissue4
lung2
prostate5
Health State
TissuesTPM*
normal1
primitive neuroectodermal tumor of the CNS94
Developmental Stage
TissuesTPM*
embryoid body14
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adrenal gland7.8
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Disease
No.Disease DescriptionRef.
1(#209880, phenotype) Central hypoventilation syndrome, congenital; CCHSOMIM
2(*603851, gene) Paired-like homeobox 2b; PHOX2BOMIM
3(#613013, phenotype) Neuroblastoma, susceptibility to, 2; NBLST2OMIM
4neuroblastoma;familial neuroblastoma;congenital central hypoventilation syndromeCGP


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