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> Protein (NX_Q99558)
Protein (NX_Q99558)
Protein
Gene SymbolMAP3K14 to neXtProt (NX_Q99558)
DescriptionMitogen-activated protein kinase kinase kinase 14
Chromosome17
Location17q21.31 (43340488 ~ 43394414) to Ensembl
Sequene Features : Isoforms 1, Variants 7, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cellular response to mechanical stimulus
.innate immune response
.positive regulation of I-kappaB kinase/NF-kappaB signaling
  + 9 more...
.ATP binding
.MAP kinase kinase kinase activity
.MAP kinase kinase activity
  + 3 more...
.cytosol
.cytoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 7 2
2014-09-19protein level
1 7 2
2014-05-27protein level
1 7 2
2014-02-25protein level
1 7 2
2013-12-09protein level
1 7 2
2013-11-01protein level
1 7 2
2013-09-12protein level
1 7 2
2013-08-17protein level
1 7 2
2013-07-15protein level
1 7 1
2013-06-11protein level
1 7 1
2013-02-12protein level
1 7 1
2012-12-20protein level
1 7 1
2012-10-30protein level
1 7 1
2012-10-07protein level
1 7 1
2012-08-24protein level
1 7 1
2012-07-28protein level
1 7 1
2012-06-08protein level
1 12 1
2012-05-07protein level
1 12 1
2012-04-10protein level
1 12 1
2012-01-13protein level
1 12 1
2011-12-20protein level
1 12 1
2011-11-11protein level
1 12 1
2011-08-23protein level
1 12 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q99558-1
45 0 0 103975.6311
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-358011,EBI-81266 IKBKB  
  .positive regulation of cation channel activity
.cellular response to tumor necrosis factor
.nucleotide-binding oligomerization domain containing signaling pathway
  + 32 more...
.scaffold protein binding
.protein heterodimerization activity
.protein homodimerization activity
  + 5 more...
.membrane raft
.CD40 receptor complex
.cytoplasmic side of plasma membrane
  + 4 more...
2 EBI-358011,EBI-81249 CHUK  
  .cellular response to tumor necrosis factor
.nucleotide-binding oligomerization domain containing signaling pathway
.mammary gland alveolus development
  + 45 more...
.scaffold protein binding
.protein heterodimerization activity
.protein homodimerization activity
  + 3 more...
.intracellular membrane-bounded organelle
.CD40 receptor complex
.cytoplasmic side of plasma membrane
  + 4 more...
3 EBI-358011,EBI-1054354 ALPL  
  .cementum mineralization
.cellular response to organic cyclic compound
.response to glucocorticoid
  + 7 more...
.metal ion binding
.pyrophosphatase activity
.alkaline phosphatase activity
.extracellular exosome
.anchored component of membrane
.extracellular matrix
  + 4 more...
4 EBI-358011,EBI-352572 HSP90AB1  
  .regulation of cellular response to heat
.fibril organization
.cellular response to interleukin-4
  + 14 more...
.poly(A) RNA binding
.TPR domain binding
.nitric-oxide synthase regulator activity
  + 4 more...
.extracellular exosome
.melanosome
.membrane
  + 4 more...
5 EBI-358011,EBI-355744 TRAF2  
  .positive regulation of extrinsic apoptotic signaling pathway
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
.negative regulation of neuron death
  + 35 more...
.sphingolipid binding
.identical protein binding
.thioesterase binding
  + 10 more...
.IRE1-TRAF2-ASK1 complex
.TRAF2-GSTP1 complex
.membrane raft
  + 7 more...
6 EBI-358011,EBI-295634 CDC37  
  .regulation of type I interferon-mediated signaling pathway
.regulation of interferon-gamma-mediated signaling pathway
.protein stabilization
  + 3 more...
.chaperone binding
.unfolded protein binding
.heat shock protein binding
.kinase binding
.extracellular exosome
.protein complex
.ruffle membrane
  + 2 more...
7 EBI-358011,EBI-359276 TRAF6  
  .positive regulation of transcription regulatory region DNA binding
.apoptotic signaling pathway
.cellular response to lipopolysaccharide
  + 61 more...
.protein N-terminus binding
.protein kinase B binding
.histone deacetylase binding
  + 10 more...
.perinuclear region of cytoplasm
.protein complex
.CD40 receptor complex
  + 10 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
blood16
bone13
brain3
cervix103
ear62
embryonic tissue4
esophagus49
heart33
intestine17
kidney18
liver4
lung8
lymph22
lymph node22
mammary gland6
mouth45
muscle9
ovary9
pancreas9
placenta3
prostate26
skin18
spleen37
stomach41
testis2
thymus75
thyroid21
tonsil58
uterus4
Health State
TissuesTPM*
normal11
cervical tumor57
colorectal tumor17
esophageal tumor57
gastrointestinal tumor33
germ cell tumor11
glioma9
head and neck tumor22
leukemia21
lung tumor9
lymphoma27
non-neoplasia31
pancreatic tumor19
prostate cancer38
skin tumor23
soft tissue/muscle tissue tumor7
uterine tumor44
Developmental Stage
TissuesTPM*
adult15
embryoid body14
blastocyst16
fetus7
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Disease
No.Disease DescriptionRef.
1(*604655, gene) Mitogen-activated protein kinase kinase kinase 14; MAP3K14OMIM


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