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> Protein (NX_Q99613)
Protein (NX_Q99613)
Protein
Gene SymbolEIF3C to neXtProt (NX_Q99613)
DescriptionEukaryotic translation initiation factor 3 subunit C
Chromosome16
Location16p11.2 (28390900 ~ 28415200) to Ensembl
Sequene Features : Isoforms 2, Variants 9, PTMs 12 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cellular protein metabolic process
.gene expression
.regulation of translational initiation
  + 3 more...
.poly(A) RNA binding
.translation initiation factor activity
.eukaryotic 48S preinitiation complex
.eukaryotic 43S preinitiation complex
.eukaryotic translation initiation factor 3 complex
.cytosol
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 9 12
2014-09-19protein level
2 13 12
2014-05-27protein level
1 13 27
2014-02-25protein level
1 11 26
2013-12-09protein level
1 5 26
2013-11-01protein level
1 5 25
2013-09-12protein level
1 5 25
2013-08-17protein level
1 5 25
2013-07-15protein level
1 4 19
2013-06-11protein level
1 4 19
2013-02-12protein level
1 2 27
2012-12-20protein level
1 2 19
2012-10-30protein level
1 5 19
2012-10-07protein level
1 5 19
2012-08-24protein level
1 5 19
2012-07-28protein level
1 5 19
2012-06-08protein level
1 6 19
2012-05-07protein level
1 5 19
2012-04-10protein level
1 3 19
2012-01-13protein level
1 4 19
2011-12-20protein level
1 4 19
2011-11-11protein level
1 4 17
2011-08-23protein level
1 4 16
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q99613-1
0 1 38 105277.4202
NX_Q99613-2
1 1 37 104035.747
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-353741,EBI-353779 DDX3X  
  .negative regulation of intrinsic apoptotic signaling pathway
.positive regulation of G1/S transition of mitotic cell cycle
.intrinsic apoptotic signaling pathway
  + 28 more...
.mRNA 5'-UTR binding
.poly(A) RNA binding
.CTPase activity
  + 14 more...
.extracellular exosome
.nuclear speck
.cytoplasmic stress granule
  + 4 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland273
ascites351
bladder234
blood408
bone237
bone marrow246
brain521
cervix371
connective tissue382
embryonic tissue446
esophagus248
eye392
heart189
intestine418
kidney384
liver272
lung340
lymph1354
lymph node44
mammary gland238
mouth1194
muscle517
nerve257
ovary305
pancreas365
placenta314
prostate237
salivary gland148
skin787
spleen618
stomach240
testis468
thymus1744
thyroid386
tonsil176
trachea463
umbilical cord1453
uterus331
vascular367
Health State
TissuesTPM*
normal318
breast (mammary gland) tumor354
cervical tumor492
chondrosarcoma374
colorectal tumor595
esophageal tumor57
gastrointestinal tumor345
germ cell tumor721
glioma289
head and neck tumor642
kidney tumor479
leukemia254
liver tumor520
lung tumor671
lymphoma872
non-neoplasia382
ovarian tumor249
pancreatic tumor695
primitive neuroectodermal tumor of the CNS677
prostate cancer144
retinoblastoma1055
skin tumor1076
soft tissue/muscle tissue tumor550
uterine tumor255
Developmental Stage
TissuesTPM*
adult211
embryoid body428
blastocyst683
neonate1029
fetus411
infant212
juvenile1115
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue77
adrenal gland83.9
appendix51.9
bone marrow46.3
cerebral cortex53.3
colon82.8
duodenum64.6
esophagus117.7
gallbladder47
heart muscle55.6
kidney115.4
liver36.4
lung102.5
lymph node60.8
ovary103.2
pancreas52.9
placenta82.3
prostate91.7
salivary gland72.9
skin88.3
small intestine95.1
spleen87.5
stomach88.5
testis110
thyroid gland149.4
urinary bladder120.7
Tissues
TissuesExpression level
adrenal glandMedium
appendixHigh
bone marrowLow
breastHigh
bronchusHigh
cerebellumHigh
cerebral cortexHigh
cervix, uterineHigh
colonHigh
duodenumHigh
endometrium 1High
endometrium 2High
epididymisHigh
esophagusHigh
fallopian tubeHigh
gallbladderHigh
heart muscleLow
hippocampusHigh
kidneyHigh
lateral ventricleMedium
liverLow
lungMedium
lymph nodeHigh
nasopharynxMedium
oral mucosaHigh
ovaryMedium
pancreasHigh
parathyroid glandMedium
placentaMedium
prostateMedium
rectumHigh
salivary glandHigh
seminal vesicleMedium
skeletal muscleLow
skin 1Medium
skin 2High
small intestineHigh
smooth muscleLow
soft tissue 1Medium
soft tissue 2Medium
spleenHigh
stomach 1Medium
stomach 2High
testisHigh
thyroid glandMedium
tonsilHigh
urinary bladderMedium
vaginaHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*603916, gene) Eukaryotic translation initiation factor 3, subunit c; EIF3COMIM


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