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> Protein (NX_Q99683)
Protein (NX_Q99683)
Protein
Gene SymbolMAP3K5 to neXtProt (NX_Q99683)
DescriptionMitogen-activated protein kinase kinase kinase 5
Chromosome6
Location6q23.3 (136878185 ~ 137113656) to Ensembl
Sequene Features : Isoforms 2, Variants 145, PTMs 12 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cellular response to reactive nitrogen species
.positive regulation of neuron death
.programmed necrotic cell death
  + 18 more...
.protein homodimerization activity
.protein phosphatase binding
.cysteine-type endopeptidase activator activity involved in apoptotic process
  + 4 more...
.IRE1-TRAF2-ASK1 complex
.protein kinase complex
.cytosol
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 145 12
2014-09-19protein level
1 113 12
2014-05-27protein level
1 113 12
2014-02-25protein level
1 112 12
2013-12-09protein level
1 95 12
2013-11-01protein level
1 90 12
2013-09-12protein level
1 90 12
2013-08-17protein level
1 90 12
2013-07-15protein level
1 61 12
2013-06-11protein level
1 61 12
2013-02-12protein level
1 23 17
2012-12-20protein level
1 23 17
2012-10-30protein level
1 30 17
2012-10-07protein level
1 30 17
2012-08-24protein level
1 20 17
2012-07-28protein level
1 20 17
2012-06-08protein level
1 24 17
2012-05-07protein level
1 23 17
2012-04-10protein level
1 23 17
2012-01-13protein level
1 17 17
2011-12-20protein level
1 17 17
2011-11-11protein level
1 17 14
2011-08-23protein level
1 17 13
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q99683-1
33 26 6 154439.1173
NX_Q99683-2
1 26 1 69795.7285
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-476263,EBI-77613 APP  
  .membrane organization
.smooth endoplasmic reticulum calcium ion homeostasis
.neuron apoptotic process
  + 41 more...
.PTB domain binding
.transition metal ion binding
.identical protein binding
  + 7 more...
.extracellular exosome
.spindle midzone
.perinuclear region of cytoplasm
  + 27 more...
2 EBI-476263,EBI-594644 TXN  
  .negative regulation of hydrogen peroxide-induced cell death
.oxidation-reduction process
.nucleobase-containing small molecule metabolic process
  + 23 more...
.poly(A) RNA binding
.oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor
.peptide disulfide oxidoreductase activity
.protein disulfide oxidoreductase activity
.extracellular exosome
.cytosol
.mitochondrion
  + 3 more...
3 EBI-476263,EBI-494743 FAS  
  .positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
.necroptotic signaling pathway
  + 39 more...
.identical protein binding
.kinase binding
.transmembrane signaling receptor activity
  + 2 more...
.extracellular exosome
.membrane raft
.CD95 death-inducing signaling complex
  + 8 more...
4 EBI-476263,EBI-296087 AKT1  
  .negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
.response to insulin-like growth factor stimulus
.negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
  + 108 more...
.14-3-3 protein binding
.phosphatidylinositol-3,4-bisphosphate binding
.identical protein binding
  + 8 more...
.ciliary basal body
.microtubule cytoskeleton
.cell-cell junction
  + 7 more...
5 EBI-476263,EBI-359815 YWHAB  
  .positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
.intrinsic apoptotic signaling pathway
.membrane organization
  + 24 more...
.phosphoprotein binding
.phosphoserine binding
.histone deacetylase binding
  + 3 more...
.extracellular exosome
.perinuclear region of cytoplasm
.melanosome
  + 7 more...
6 EBI-476263,EBI-714559 ARRB2  
  .positive regulation of DNA biosynthetic process
.negative regulation of release of cytochrome c from mitochondria
.positive regulation of ERK1 and ERK2 cascade
  + 35 more...
.protein complex scaffold
.angiotensin receptor binding
.ubiquitin protein ligase binding
  + 3 more...
.postsynaptic membrane
.dendritic spine
.cytoplasmic vesicle
  + 8 more...
7 EBI-476263,EBI-602462 MAP2K3  
  .cardiac muscle contraction
.stress-activated MAPK cascade
.positive regulation of transcription, DNA-templated
  + 21 more...
.protein kinase binding
.ATP binding
.protein tyrosine kinase activity
  + 2 more...
.membrane
.cytosol
.cytoplasm
.nucleoplasm
8 EBI-476263,EBI-743313 ARRB1  
  .positive regulation of histone H4 acetylation
.positive regulation of ERK1 and ERK2 cascade
.membrane organization
  + 24 more...
.transcription regulatory region DNA binding
.cysteine-type endopeptidase inhibitor activity involved in apoptotic process
.angiotensin receptor binding
  + 5 more...
.cytoplasmic vesicle
.pseudopodium
.cytoplasmic vesicle membrane
  + 9 more...
9 EBI-476263,EBI-915984 PPP3R1  
  .positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
.intrinsic apoptotic signaling pathway
.positive regulation of NFAT protein import into nucleus
  + 8 more...
.protein domain specific binding
.calmodulin binding
.calcium ion binding
.calcium-dependent protein serine/threonine phosphatase activity
.sarcolemma
.calcineurin complex
.cytosol
.nucleoplasm
10 EBI-476263,EBI-347088 YWHAZ  
  .positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
.intrinsic apoptotic signaling pathway
.Golgi reassembly
  + 14 more...
.poly(A) RNA binding
.identical protein binding
.ubiquitin protein ligase binding
  + 2 more...
.blood microparticle
.extracellular exosome
.perinuclear region of cytoplasm
  + 13 more...
11 EBI-476263,EBI-395421 SMN2  
  .ncRNA metabolic process
.gene expression
.nervous system development
  + 2 more...
.identical protein binding
.RNA binding
.Gemini of coiled bodies
.SMN-Sm protein complex
.SMN complex
  + 7 more...
12 EBI-476263,EBI-2871881 DAB2IP  
  .positive regulation of apoptotic signaling pathway
.positive regulation of neuron migration
.negative regulation of cyclin catabolic process
  + 69 more...
.14-3-3 protein binding
.phosphatidylinositol-4-phosphate binding
.protein phosphatase 2A binding
  + 15 more...
.AIP1-IRE1 complex
.parallel fiber
.extracellular exosome
  + 10 more...
13 EBI-476263,EBI-2687480 ZNF622  
  .positive regulation of JNK cascade
.positive regulation of MAPK cascade
.positive regulation of apoptotic process
  + 2 more...
.poly(A) RNA binding
.zinc ion binding
.Golgi apparatus
.cytoplasm
.nucleolus
14 EBI-476263,EBI-348259 MCRS1  
  .histone H4-K16 acetylation
.histone H4-K8 acetylation
.histone H4-K5 acetylation
  + 6 more...
.N/A .MLL1 complex
.Ino80 complex
.cell junction
  + 5 more...
15 EBI-476263,EBI-77321 DAXX  
  .positive regulation of apoptotic signaling pathway
.positive regulation of neuron death
.negative regulation of transcription, DNA-templated
  + 13 more...
.androgen receptor binding
.protein N-terminus binding
.protein homodimerization activity
  + 10 more...
.SWI/SNF superfamily-type complex
.PML body
.cytosol
  + 5 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
adrenal gland60
ascites25
bladder66
bone27
bone marrow41
brain23
connective tissue33
embryonic tissue4
eye38
heart22
intestine4
kidney9
liver24
lung41
lymph node111
mammary gland13
muscle28
nerve64
ovary29
pancreas14
parathyroid48
prostate36
spleen18
stomach31
testis13
thyroid85
trachea38
uterus25
Health State
TissuesTPM*
normal23
bladder carcinoma113
breast (mammary gland) tumor21
colorectal tumor8
gastrointestinal tumor33
germ cell tumor7
head and neck tumor22
leukemia84
liver tumor31
lung tumor29
non-neoplasia62
pancreatic tumor9
prostate cancer9
uterine tumor22
Developmental Stage
TissuesTPM*
adult27
blastocyst16
fetus14
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue11.6
adrenal gland94.8
appendix13.2
bone marrow7.8
cerebral cortex21.1
colon9.9
duodenum7.6
esophagus10.6
gallbladder8.8
heart muscle8
kidney9.7
liver5.2
lung10.9
lymph node13.4
ovary49.6
pancreas14.7
placenta5.9
prostate18.4
salivary gland3.5
skin7.8
small intestine7.7
spleen11
stomach13.8
testis15.3
thyroid gland14
urinary bladder21.7
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*602448, gene) Mitogen-activated protein kinase kinase kinase 5; MAP3K5OMIM


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