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> Protein (NX_Q99704)
Protein (NX_Q99704)
Protein
Gene SymbolDOK1 to neXtProt (NX_Q99704)
DescriptionDocking protein 1
Chromosome2
Location2p13.1 (74776153 ~ 74784681) to Ensembl
Sequene Features : Isoforms 3, Variants 63, PTMs 15 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.insulin receptor signaling pathway
.Ras protein signal transduction
.transmembrane receptor protein tyrosine kinase signaling pathway
  + 2 more...
.receptor signaling protein activity .perinuclear region of cytoplasm
.cytosol
.cytoplasm
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 63 15
2014-09-19protein level
3 53 15
2014-05-27protein level
3 53 15
2014-02-25protein level
3 52 15
2013-12-09protein level
3 37 15
2013-11-01protein level
3 35 15
2013-09-12protein level
3 35 15
2013-08-17protein level
3 35 15
2013-07-15protein level
3 25 15
2013-06-11protein level
3 25 15
2013-02-12protein level
3 13 27
2012-12-20protein level
3 13 27
2012-10-30protein level
3 14 27
2012-10-07protein level
3 14 14
2012-08-24protein level
3 13 14
2012-07-28protein level
3 13 14
2012-06-08protein level
3 16 14
2012-05-07protein level
3 12 14
2012-04-10protein level
3 12 14
2012-01-13protein level
3 10 14
2011-12-20protein level
3 10 14
2011-11-11protein level
3 10 15
2011-08-23protein level
3 10 15
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q99704-1
1 21 0 52359.0946
NX_Q99704-2
2 6 0 19357.8526
NX_Q99704-3
1 15 0 37381.5037
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1384360,EBI-641062 ERBB2  
  .regulation of ERK1 and ERK2 cascade
.positive regulation of epithelial cell proliferation
.oligodendrocyte differentiation
  + 35 more...
.protein dimerization activity
.protein heterodimerization activity
.ErbB-3 class receptor binding
  + 9 more...
.perinuclear region of cytoplasm
.receptor complex
.cytoplasmic vesicle
  + 7 more...
2 EBI-1384360,EBI-8541270 SRMS  
  .innate immune response
.regulation of cell proliferation
.peptidyl-tyrosine autophosphorylation
  + 4 more...
.ATP binding
.receptor binding
.non-membrane spanning protein tyrosine kinase activity
.protein tyrosine kinase activity
.extrinsic component of cytoplasmic side of plasma membrane
.cytoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
adrenal gland30
blood114
bone13
bone marrow41
brain10
cervix41
connective tissue67
embryonic tissue14
eye9
heart33
intestine25
kidney23
liver4
lung14
lymph node44
mammary gland39
mouth15
muscle9
ovary9
pancreas28
placenta42
prostate5
skin18
spleen18
testis6
thymus12
tonsil58
umbilical cord72
uterus25
vascular19
Health State
TissuesTPM*
normal21
adrenal tumor79
breast (mammary gland) tumor42
cervical tumor57
chondrosarcoma60
colorectal tumor17
germ cell tumor22
head and neck tumor7
kidney tumor14
leukemia84
liver tumor10
lung tumor19
non-neoplasia62
pancreatic tumor9
primitive neuroectodermal tumor of the CNS31
retinoblastoma21
skin tumor31
uterine tumor33
Developmental Stage
TissuesTPM*
adult22
embryoid body14
neonate96
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue13.9
adrenal gland5.4
appendix14.8
bone marrow12.6
cerebral cortex4.2
colon8.4
duodenum6.1
esophagus2.9
gallbladder8.8
heart muscle2.7
kidney3.9
liver1.6
lung11.9
lymph node17.9
ovary5.7
pancreas3.3
placenta6.5
prostate4.7
salivary gland3.5
skin2.2
small intestine7.1
spleen18.4
stomach9.9
testis3.8
thyroid gland5.5
urinary bladder9.4
Tissues
TissuesExpression level
adrenal glandHigh
bone marrowLow
breastMedium
bronchusMedium
cerebellumHigh
cerebral cortexHigh
cervix, uterineHigh
endometrium 2Low
epididymisHigh
esophagusMedium
fallopian tubeMedium
gallbladderHigh
hippocampusHigh
kidneyMedium
lateral ventricleHigh
lungLow
lymph nodeMedium
nasopharynxMedium
oral mucosaHigh
pancreasHigh
placentaHigh
rectumHigh
skeletal muscleLow
skin 1High
skin 2High
small intestineLow
stomach 1Medium
stomach 2Low
testisHigh
thyroid glandMedium
tonsilHigh
urinary bladderMedium
vaginaHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*602919, gene) Docking protein 1; DOK1OMIM


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