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> Protein (NX_Q99708)
Protein (NX_Q99708)
Protein
Gene SymbolRBBP8 to neXtProt (NX_Q99708)
DescriptionDNA endonuclease RBBP8
Chromosome18
Location18q11.2 (20378224 ~ 20606451) to Ensembl
Sequene Features : Isoforms 3, Variants 99, PTMs 15 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.meiotic cell cycle
.cell division
.G2 DNA damage checkpoint
  + 10 more...
.damaged DNA binding
.RNA polymerase II transcription corepressor activity
.RNA polymerase II repressing transcription factor binding
.single-stranded DNA endodeoxyribonuclease activity
.transcriptional repressor complex
.nucleolus
.nucleoplasm
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 99 15
2014-09-19protein level
3 79 15
2014-05-27protein level
3 75 15
2014-02-25protein level
3 74 15
2013-12-09protein level
3 58 15
2013-11-01protein level
3 54 15
2013-09-12protein level
3 54 15
2013-08-17protein level
3 54 15
2013-07-15protein level
3 39 15
2013-06-11protein level
3 39 15
2013-02-12protein level
3 26 31
2012-12-20protein level
2 21 22
2012-10-30protein level
2 26 22
2012-10-07protein level
2 26 11
2012-08-24protein level
2 25 11
2012-07-28protein level
2 25 11
2012-06-08protein level
2 43 11
2012-05-07protein level
2 37 11
2012-04-10protein level
1 24 8
2012-01-13protein level
1 15 8
2011-12-20protein level
1 15 8
2011-11-11protein level
1 15 7
2011-08-23protein level
1 15 7
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q99708-1
0 42 0 101878.0727
NX_Q99708-2
1 42 0 102545.4114
NX_Q99708-3
4 37 0 98372.9579
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-10203615,EBI-8639312 LMO1  
  .positive regulation of transcription from RNA polymerase II promoter
.negative regulation of transcription from RNA polymerase II promoter
.zinc ion binding .nucleus
2 EBI-745715,EBI-349905 BRCA1  
  .positive regulation of histone H4-K16 acetylation
.positive regulation of histone H3-K9 acetylation
.negative regulation of reactive oxygen species metabolic process
  + 51 more...
.androgen receptor binding
.transcription regulatory region DNA binding
.ubiquitin protein ligase binding
  + 9 more...
.BRCA1-A complex
.protein complex
.BRCA1-BARD1 complex
  + 9 more...
3 EBI-10203615,EBI-2798728 LMO4  
  .regulation of cell activation
.thymus development
.positive regulation of transcription from RNA polymerase II promoter
  + 8 more...
.zinc ion binding
.transcription factor binding
.sequence-specific DNA binding transcription factor activity
.enhancer sequence-specific DNA binding
.transcription factor complex
4 EBI-10203615,EBI-714158 PIN1  
  .negative regulation of cell motility
.negative regulation of ERK1 and ERK2 cascade
.regulation of pathway-restricted SMAD protein phosphorylation
  + 11 more...
.phosphothreonine binding
.phosphoserine binding
.GTPase activating protein binding
  + 2 more...
.midbody
.nuclear speck
.cytoplasm
  + 2 more...
5 EBI-745715,EBI-944667 EXO1  
  .RNA phosphodiester bond hydrolysis, endonucleolytic
.nucleic acid phosphodiester bond hydrolysis
.meiotic cell cycle
  + 6 more...
.double-stranded DNA 5'-3' exodeoxyribonuclease activity
.flap endonuclease activity
.metal ion binding
  + 7 more...
.nucleoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
ascites50
blood16
bone27
bone marrow20
brain13
cervix164
connective tissue26
embryonic tissue14
esophagus99
eye28
heart33
intestine21
kidney18
liver38
lung17
lymph22
lymph node33
mammary gland132
mouth45
muscle28
nerve64
ovary19
pharynx24
placenta7
prostate15
skin66
stomach20
testis66
thymus37
thyroid64
tonsil58
umbilical cord145
uterus38
Health State
TissuesTPM*
normal23
adrenal tumor79
breast (mammary gland) tumor128
cervical tumor231
chondrosarcoma24
colorectal tumor35
esophageal tumor115
gastrointestinal tumor42
germ cell tumor30
glioma18
head and neck tumor44
liver tumor72
lung tumor9
lymphoma27
ovarian tumor26
primitive neuroectodermal tumor of the CNS15
retinoblastoma107
skin tumor79
soft tissue/muscle tissue tumor23
uterine tumor55
Developmental Stage
TissuesTPM*
adult30
blastocyst32
neonate96
fetus23
juvenile53
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue6.8
adrenal gland7.3
appendix10.6
bone marrow13.1
cerebral cortex5.7
colon13.5
duodenum8.2
esophagus19.7
gallbladder13.4
heart muscle3.9
kidney22.4
liver7.1
lung11.6
lymph node13.4
ovary3.1
pancreas6.1
placenta8.1
prostate8.4
salivary gland11.9
skin21.5
small intestine9
spleen5.2
stomach13.6
testis26.9
thyroid gland18.8
urinary bladder15.7
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#251255, phenotype) Jawad syndrome; JWDSOMIM
2(*604124, gene) Retinoblastoma-binding protein 8; RBBP8OMIM
3(#606744, phenotype) Seckel syndrome 2; SCKL2OMIM


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