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> Protein (NX_Q99728)
Protein (NX_Q99728)
Protein
Gene SymbolBARD1 to neXtProt (NX_Q99728)
DescriptionBRCA1-associated RING domain protein 1
Chromosome2
Location2q35 (215590370 ~ 215674428) to Ensembl
Sequene Features : Isoforms 4, Variants 112, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.protein K6-linked ubiquitination
.negative regulation of protein export from nucleus
.positive regulation of protein catabolic process
  + 9 more...
.protein heterodimerization activity
.protein homodimerization activity
.kinase binding
  + 4 more...
.BRCA1-A complex
.intracellular membrane-bounded organelle
.BRCA1-BARD1 complex
  + 5 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
4 112 8
2014-09-19protein level
4 97 9
2014-05-27protein level
1 97 10
2014-02-25protein level
1 96 10
2013-12-09protein level
1 74 10
2013-11-01protein level
1 70 9
2013-09-12protein level
1 70 9
2013-08-17protein level
1 70 9
2013-07-15protein level
1 55 8
2013-06-11protein level
1 55 8
2013-02-12protein level
1 34 7
2012-12-20protein level
1 36 7
2012-10-30protein level
1 44 7
2012-10-07protein level
1 44 7
2012-08-24protein level
1 34 7
2012-07-28protein level
1 33 7
2012-06-08protein level
1 34 7
2012-05-07protein level
1 34 7
2012-04-10protein level
1 34 7
2012-01-13protein level
1 26 7
2011-12-20protein level
1 26 7
2011-11-11protein level
1 26 6
2011-08-23protein level
1 26 6
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q99728-1
0 37 0 86592.6659
NX_Q99728-2
1 36 0 84520.7074
NX_Q99728-3
1 33 0 75426.274
NX_Q99728-4
1 3 0 14352.9399
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-473181,EBI-473271 TCERG1  
  .transcription from RNA polymerase II promoter
.negative regulation of transcription from RNA polymerase II promoter
.poly(A) RNA binding
.transcription coactivator activity
.RNA polymerase II transcription corepressor activity
.RNA polymerase II repressing transcription factor binding
.actin cytoskeleton
.nucleolus
.nucleus
2 EBI-473181,EBI-473199 KAT7  
  .histone H4-K12 acetylation
.histone H4-K8 acetylation
.histone H4-K5 acetylation
  + 5 more...
.zinc ion binding
.histone acetyltransferase activity
.sequence-specific DNA binding transcription factor activity
.cytoplasm
.nucleoplasm
.histone acetyltransferase complex
3 EBI-473181,EBI-372832 PARN  
  .RNA phosphodiester bond hydrolysis, exonucleolytic
.nucleic acid phosphodiester bond hydrolysis
.gene expression
  + 5 more...
.metal ion binding
.poly(A) RNA binding
.protein kinase binding
  + 4 more...
.cytosol
.cytoplasm
.nucleolus
.nucleus
4 EBI-473181,EBI-740738 LDOC1  
  .negative regulation of cell proliferation .N/A .nucleolus
.nucleus
5 EBI-473181,EBI-711360 CSTF2  
  .mRNA 3'-end processing
.gene expression
.RNA splicing
  + 5 more...
.poly(A) RNA binding
.RNA binding
.nucleotide binding
.cleavage body
.mRNA cleavage and polyadenylation specificity factor complex
.nucleoplasm
.nucleus
6 EBI-473181,EBI-349905 BRCA1  
  .positive regulation of histone H4-K16 acetylation
.positive regulation of histone H3-K9 acetylation
.negative regulation of reactive oxygen species metabolic process
  + 51 more...
.androgen receptor binding
.transcription regulatory region DNA binding
.ubiquitin protein ligase binding
  + 9 more...
.BRCA1-A complex
.protein complex
.BRCA1-BARD1 complex
  + 9 more...
7 EBI-473181,EBI-1789619 CSTF1  
  .mRNA 3'-end processing
.gene expression
.RNA splicing
  + 6 more...
.poly(A) RNA binding
.RNA binding
.intracellular membrane-bounded organelle
.cytoplasm
.nucleoplasm
.nucleus
8 EBI-473181,EBI-618309 GOLGA2  
  .negative regulation of protein binding
.mitotic cell cycle
.syntaxin binding
.protein kinase binding
.Golgi cisterna membrane
.ER to Golgi transport vesicle
.cis-Golgi network
  + 4 more...
9 EBI-473181,EBI-523590 CHD3  
  .centrosome organization
.DNA duplex unwinding
.chromatin modification
  + 6 more...
.poly(A) RNA binding
.zinc ion binding
.ATP binding
  + 3 more...
.intermediate filament cytoskeleton
.NuRD complex
.centrosome
  + 4 more...
10 EBI-473181,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
11 EBI-473181,EBI-10175124 FAM9B  
  .spermatid development .N/A .nucleoplasm
12 EBI-473181,EBI-739624 CEP70  
  .organelle organization
.mitotic cell cycle
.G2/M transition of mitotic cell cycle
.N/A .nuclear membrane
.cytosol
.centrosome
  + 2 more...
13 EBI-473181,EBI-473176 KIAA1377  
  .cilium assembly
.cytoplasmic microtubule organization
.mitotic spindle organization
.N/A .ciliary base
.midbody
.centrosome
.cytoplasm
14 EBI-473181,EBI-466061 GIT1  
  .ephrin receptor signaling pathway
.regulation of cytokinesis
.regulation of G-protein coupled receptor protein signaling pathway
.axon guidance
.zinc ion binding
.GTPase activator activity
.aggresome
.membrane
.focal adhesion
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites25
blood16
bone marrow20
cervix61
connective tissue147
embryonic tissue14
eye9
heart11
intestine12
kidney9
liver9
lung5
lymph45
lymph node100
mammary gland13
mouth30
muscle28
nerve64
pancreas32
placenta14
prostate10
skin9
testis32
trachea19
uterus12
vascular19
Health State
TissuesTPM*
normal14
breast (mammary gland) tumor21
cervical tumor28
colorectal tumor8
gastrointestinal tumor25
germ cell tumor49
head and neck tumor7
kidney tumor14
leukemia31
lymphoma27
pancreatic tumor28
primitive neuroectodermal tumor of the CNS7
prostate cancer19
retinoblastoma43
skin tumor7
soft tissue/muscle tissue tumor207
Developmental Stage
TissuesTPM*
adult24
embryoid body28
blastocyst16
neonate32
fetus26
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue1.8
appendix4
bone marrow8.8
cerebral cortex1.4
colon2.7
duodenum4
esophagus4.9
gallbladder2.3
heart muscle1.3
liver1.2
lung2.1
lymph node5.3
ovary2.6
placenta1.9
prostate2.6
salivary gland7.3
skin5.2
small intestine2.2
spleen2.9
stomach2.1
testis6.4
thyroid gland1.5
urinary bladder2.3
Tissues
TissuesExpression level
adrenal glandLow
appendixLow
bone marrowLow
breastMedium
bronchusLow
cerebellumMedium
cerebral cortexMedium
colonMedium
duodenumLow
endometrium 1Medium
endometrium 2Low
epididymisMedium
esophagusMedium
fallopian tubeLow
gallbladderMedium
heart muscleMedium
hippocampusMedium
kidneyMedium
lateral ventricleMedium
liverMedium
lungMedium
lymph nodeLow
nasopharynxMedium
oral mucosaLow
pancreasLow
parathyroid glandLow
placentaLow
prostateLow
rectumMedium
salivary glandLow
seminal vesicleMedium
skeletal muscleMedium
skin 1Medium
skin 2Medium
small intestineLow
smooth muscleLow
soft tissue 1Low
spleenLow
stomach 1Medium
stomach 2Low
testisMedium
thyroid glandLow
tonsilLow
urinary bladderMedium
vaginaLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*601593, gene) Brca1-associated ring domain 1; BARD1OMIM


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