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> Protein (NX_Q99757)
Protein (NX_Q99757)
Protein
Gene SymbolTXN2 to neXtProt (NX_Q99757)
DescriptionThioredoxin, mitochondrial
Chromosome22
Location22q12.3 (36863083 ~ 36878077) to Ensembl
Sequene Features : Isoforms 1, Variants 15, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.oxidation-reduction process
.response to axon injury
.cell redox homeostasis
  + 12 more...
.peptide-methionine (R)-S-oxide reductase activity
.oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor
.protein disulfide oxidoreductase activity
.peptide-methionine (S)-S-oxide reductase activity
.neuronal cell body
.dendrite
.mitochondrial matrix
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 15 3
2014-09-19protein level
1 11 3
2014-05-27protein level
1 11 3
2014-02-25protein level
1 11 2
2013-12-09protein level
1 9 2
2013-11-01protein level
1 9 2
2013-09-12protein level
1 9 2
2013-08-17protein level
1 9 2
2013-07-15protein level
1 6 2
2013-06-11protein level
1 6 2
2013-02-12protein level
1 4 2
2012-12-20protein level
1 3 2
2012-10-30protein level
1 4 2
2012-10-07protein level
1 4 2
2012-08-24protein level
1 4 2
2012-07-28protein level
1 4 2
2012-06-08protein level
1 5 2
2012-05-07protein level
1 5 2
2012-04-10protein level
1 5 2
2012-01-13protein level
1 2 2
2011-12-20protein level
1 2 2
2011-11-11protein level
1 2 2
2011-08-23protein level
1 2 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q99757-1
7 0 0 18371.5754
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-2932492,EBI-2515299 SSNA1  
  .ciliary receptor clustering involved in smoothened signaling pathway
.intraciliary transport
.organelle organization
  + 2 more...
.N/A .ciliary basal body
.cytosol
.centrosome
.nucleus
2 EBI-2932492,EBI-10176632 ZBTB14  
  .negative regulation of transcription, DNA-templated
.transcription from RNA polymerase II promoter
.negative regulation of transcription from RNA polymerase II promoter
.metal ion binding
.transcription regulatory region DNA binding
.sequence-specific DNA binding
  + 2 more...
.cytoplasm
.nucleoplasm
.nucleus
3 EBI-2932492,EBI-81290 TRIM21  
  .negative regulation of viral release from host cell
.negative regulation of protein deubiquitination
.protein trimerization
  + 16 more...
.identical protein binding
.ligase activity
.zinc ion binding
  + 3 more...
.ribonucleoprotein complex
.cytosol
.cytoplasm
  + 3 more...
4 EBI-2932492,EBI-739870 DCTD  
  .nucleobase-containing small molecule metabolic process
.pyrimidine nucleoside biosynthetic process
.small molecule metabolic process
  + 3 more...
.zinc ion binding
.dCMP deaminase activity
.extracellular exosome
.cytosol
5 EBI-2932492,EBI-10178634 MAGEA11  
  .N/A .N/A .cytoplasm
.nucleoplasm
.nucleus
6 EBI-2932492,EBI-744831 RPIA  
  .small molecule metabolic process
.pentose-phosphate shunt, non-oxidative branch
.pentose-phosphate shunt
.carbohydrate metabolic process
.monosaccharide binding
.ribose-5-phosphate isomerase activity
.intracellular membrane-bounded organelle
.cytosol
7 EBI-2932492,EBI-355546 PSME3  
  .negative regulation of extrinsic apoptotic signaling pathway
.positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
  + 24 more...
.MDM2/MDM4 family protein binding
.endopeptidase activator activity
.identical protein binding
.p53 binding
.membrane
.proteasome activator complex
.cytosol
  + 4 more...
8 EBI-2932492,EBI-432924 AP2B1  
  .clathrin-mediated endocytosis
.regulation of defense response to virus by virus
.ephrin receptor signaling pathway
  + 8 more...
.clathrin binding
.protein transporter activity
.signal sequence binding
.intracellular membrane-bounded organelle
.clathrin-coated endocytic vesicle membrane
.endocytic vesicle membrane
  + 4 more...
9 EBI-2932492,EBI-739717 MAPRE2  
  .cell division
.cell proliferation
.signal transduction
.mitotic nuclear division
.N/A .microtubule plus-end
.microtubule cytoskeleton
.cytoplasm
10 EBI-2932492,EBI-742327 TRIP6  
  .focal adhesion assembly
.positive regulation of cell migration
.release of cytoplasmic sequestered NF-kappaB
  + 2 more...
.thyroid hormone receptor binding
.poly(A) RNA binding
.kinase binding
  + 2 more...
.focal adhesion
.plasma membrane
.cytoskeleton
  + 2 more...
11 EBI-2932492,EBI-742948 MTUS2  
  .N/A .protein homodimerization activity
.microtubule binding
.microtubule
.cytoplasm
.nucleus
12 EBI-2932492,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
13 EBI-2932492,EBI-741181 AGTRAP  
  .regulation of blood pressure
.response to hypoxia
.angiotensin type II receptor activity .intracellular membrane-bounded organelle
.cytoplasmic vesicle membrane
.integral component of membrane
  + 6 more...
14 EBI-2932492,EBI-2512147 RBM45  
  .cell differentiation
.nervous system development
.poly(A) RNA binding
.RNA binding
.nucleotide binding
.cytoplasm
.nucleoplasm
.nucleus
15 EBI-2932492,EBI-1380680 SCYL3  
  .cell migration
.protein phosphorylation
.transferase activity, transferring phosphorus-containing groups
.ATP binding
.lamellipodium
.Golgi apparatus
.cytoplasm
16 EBI-2932492,EBI-10175124 FAM9B  
  .spermatid development .N/A .nucleoplasm
17 EBI-2932492,EBI-2799833 VPS52  
  .embryonic ectodermal digestive tract development
.protein transport
.ectodermal cell differentiation
.syntaxin binding .perinuclear region of cytoplasm
.endosome membrane
.Golgi apparatus
18 EBI-2932492,EBI-724333 PPCDC  
  .small molecule metabolic process
.pantothenate metabolic process
.coenzyme A biosynthetic process
  + 3 more...
.phosphopantothenoylcysteine decarboxylase activity .cytosol
19 EBI-2932492,EBI-740711 TIFA  
  .I-kappaB kinase/NF-kappaB signaling .N/A .N/A
20 EBI-2932492,EBI-750345 REEP6  
  .regulation of intracellular transport .N/A .apical part of cell
.rod spherule
.integral component of membrane
  + 2 more...
21 EBI-2932492,EBI-748896 MRFAP1L1  
  .N/A .identical protein binding .N/A
22 EBI-2932492,EBI-10173858 CCDC114  
  .outer dynein arm assembly .N/A .outer dynein arm
.cilium
23 EBI-2932492,EBI-913954 RABGEF1  
  .negative regulation of Kit signaling pathway
.negative regulation of interleukin-6 secretion
.regulation of Fc receptor mediated stimulatory signaling pathway
  + 9 more...
.Rab GTPase binding
.Rab guanyl-nucleotide exchange factor activity
.zinc ion binding
  + 2 more...
.recycling endosome
.vesicle
.early endosome
24 EBI-2932492,EBI-357085 STUB1  
  .positive regulation of chaperone-mediated protein complex assembly
.cellular response to misfolded protein
.protein K63-linked ubiquitination
  + 16 more...
.ubiquitin protein ligase activity
.Hsp90 protein binding
.misfolded protein binding
  + 12 more...
.extracellular exosome
.intermediate filament cytoskeleton
.nuclear inclusion body
  + 7 more...
25 EBI-2932492,EBI-726739 MAPRE3  
  .positive regulation of microtubule plus-end binding
.cell division
.positive regulation of transcription, DNA-templated
  + 2 more...
.microtubule binding .perinuclear region of cytoplasm
.microtubule plus-end
.midbody
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland121
ascites100
bladder33
blood49
bone27
bone marrow164
brain33
cervix103
connective tissue6
embryonic tissue75
eye86
heart55
intestine56
kidney61
larynx85
liver29
lung50
lymph22
lymph node22
mammary gland33
muscle56
nerve64
ovary68
pancreas51
pharynx319
pituitary gland121
placenta38
prostate89
salivary gland542
skin104
spleen56
stomach41
testis25
thyroid85
uterus60
vascular19
Health State
TissuesTPM*
normal51
adrenal tumor158
breast (mammary gland) tumor53
cervical tumor86
chondrosarcoma12
colorectal tumor35
gastrointestinal tumor92
germ cell tumor26
glioma65
head and neck tumor67
kidney tumor87
leukemia127
liver tumor62
lung tumor19
lymphoma83
non-neoplasia20
ovarian tumor105
pancreatic tumor19
primitive neuroectodermal tumor of the CNS70
prostate cancer67
retinoblastoma43
skin tumor143
uterine tumor66
Developmental Stage
TissuesTPM*
adult59
embryoid body28
blastocyst97
fetus59
infant42
juvenile53
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue46.1
adrenal gland106.2
appendix44.7
bone marrow41.6
cerebral cortex51.4
colon62.3
duodenum67.7
esophagus52.6
gallbladder45.3
heart muscle81
kidney75.7
liver61.3
lung40.6
lymph node51.6
ovary63.4
pancreas24.2
placenta44.5
prostate45
salivary gland41.8
skin33.7
small intestine57.1
spleen45.5
stomach55.8
testis38.3
thyroid gland60.4
urinary bladder52.9
Tissues
TissuesExpression level
adrenal glandHigh
appendixHigh
bone marrowHigh
breastHigh
bronchusHigh
cerebellumHigh
cerebral cortexHigh
cervix, uterineHigh
colonHigh
duodenumHigh
endometrium 1High
endometrium 2High
epididymisHigh
esophagusHigh
fallopian tubeHigh
gallbladderHigh
heart muscleMedium
hippocampusHigh
kidneyMedium
lateral ventricleHigh
liverHigh
lungHigh
lymph nodeHigh
nasopharynxHigh
oral mucosaHigh
ovaryMedium
pancreasHigh
parathyroid glandHigh
placentaHigh
prostateMedium
rectumHigh
salivary glandMedium
seminal vesicleHigh
skeletal muscleMedium
skin 1Medium
skin 2Medium
small intestineHigh
smooth muscleMedium
soft tissue 1Low
soft tissue 2Low
spleenMedium
stomach 1High
stomach 2High
testisHigh
thyroid glandHigh
tonsilHigh
urinary bladderHigh
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*609063, gene) Thioredoxin 2; TXN2OMIM


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