Home| Contact Us

HOME SEARCH STATISTICS
> Protein (NX_Q99759)
Protein (NX_Q99759)
Protein
Gene SymbolMAP3K3 to neXtProt (NX_Q99759)
DescriptionMitogen-activated protein kinase kinase kinase 3
Chromosome17
Location17q23.3 (61699775 ~ 61773663) to Ensembl
Sequene Features : Isoforms 2, Variants 83, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of p38MAPK cascade
.protein autophosphorylation
.positive regulation of I-kappaB kinase/NF-kappaB signaling
  + 5 more...
.metal ion binding
.ATP binding
.MAP kinase kinase kinase activity
  + 2 more...
.cytosol
.intracellular
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 83 9
2014-09-19protein level
2 60 9
2014-05-27protein level
2 60 9
2014-02-25protein level
2 58 9
2013-12-09protein level
2 50 9
2013-11-01protein level
2 49 9
2013-09-12protein level
2 49 9
2013-08-17protein level
2 49 9
2013-07-15protein level
2 36 9
2013-06-11protein level
2 36 9
2013-02-12protein level
2 20 52
2012-12-20protein level
2 19 52
2012-10-30protein level
2 20 52
2012-10-07protein level
2 20 26
2012-08-24protein level
2 18 26
2012-07-28protein level
2 18 26
2012-06-08protein level
2 21 26
2012-05-07protein level
2 13 26
2012-04-10protein level
2 13 26
2012-01-13protein level
2 9 26
2011-12-20protein level
2 9 26
2011-11-11protein level
2 9 26
2011-08-23protein level
2 9 26
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q99759-1
0 25 6 70853.1501
NX_Q99759-2
1 25 6 74042.786
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-307281,EBI-359815 YWHAB  
  .positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
.intrinsic apoptotic signaling pathway
.membrane organization
  + 24 more...
.phosphoprotein binding
.phosphoserine binding
.histone deacetylase binding
  + 3 more...
.extracellular exosome
.perinuclear region of cytoplasm
.melanosome
  + 7 more...
2 EBI-307281,EBI-356498 YWHAE  
  .negative regulation of peptidyl-serine dephosphorylation
.regulation of potassium ion transmembrane transporter activity
.positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
  + 27 more...
.phosphoprotein binding
.phosphoserine binding
.protein heterodimerization activity
  + 7 more...
.extracellular exosome
.melanosome
.cytoplasmic vesicle membrane
  + 6 more...
3 EBI-307281,EBI-307294 MAP2K5  
  .negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
.negative regulation of chemokine (C-X-C motif) ligand 2 production
.negative regulation of cell migration involved in sprouting angiogenesis
  + 17 more...
.metal ion binding
.ATP binding
.protein tyrosine kinase activity
  + 3 more...
.cytosol
.spindle
.nucleus
.intracellular
4 EBI-307281,EBI-307556 TRAF7  
  .positive regulation of apoptotic signaling pathway
.cellular response to interleukin-6
.positive regulation of MAPK cascade
  + 7 more...
.ligase activity
.zinc ion binding
.ubiquitin-protein transferase activity
.perinuclear region of cytoplasm
.intracellular membrane-bounded organelle
.cytoplasmic membrane-bounded vesicle
  + 4 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites25
blood49
bone83
bone marrow61
brain45
connective tissue60
embryonic tissue42
eye19
intestine21
kidney33
larynx42
liver9
lung35
lymph519
lymph node55
mammary gland52
mouth30
muscle28
ovary19
pancreas37
parathyroid48
pharynx49
placenta56
prostate42
skin147
spleen56
stomach20
testis71
thymus50
thyroid21
trachea38
umbilical cord72
uterus60
vascular77
Health State
TissuesTPM*
normal47
breast (mammary gland) tumor32
chondrosarcoma132
colorectal tumor8
gastrointestinal tumor25
germ cell tumor60
glioma37
head and neck tumor37
kidney tumor58
leukemia10
liver tumor20
lung tumor9
lymphoma318
non-neoplasia31
ovarian tumor39
pancreatic tumor38
primitive neuroectodermal tumor of the CNS118
skin tumor71
soft tissue/muscle tissue tumor55
uterine tumor44
Developmental Stage
TissuesTPM*
adult41
blastocyst65
neonate32
fetus50
infant42
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue22.5
adrenal gland13.3
appendix26.8
bone marrow23.5
cerebral cortex8.7
colon11
duodenum8.5
esophagus18.2
gallbladder26.1
heart muscle33.8
kidney16.4
liver5.3
lung30.2
lymph node25.1
ovary23.6
pancreas6.2
placenta21.2
prostate16.8
salivary gland11.3
skin16.5
small intestine10
spleen33.7
stomach11.1
testis21.8
thyroid gland12.9
urinary bladder22
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*602539, gene) Mitogen-activated kinase kinase kinase 3; MAP3K3OMIM


#424, YPRC/BPRC, Industry-University Research Center, Yonsei Univ., Seodaemun-gu, Seoul, Korea, 120-749
Tel: +82-2-2123-6626, Fax: +82-2-393-6589
2014-2019 (C) Yonsei Proteome Research Center