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> Protein (NX_Q99814)
Protein (NX_Q99814)
Protein
Gene SymbolEPAS1 to neXtProt (NX_Q99814)
DescriptionEndothelial PAS domain-containing protein 1
Chromosome2
Location2p21 (46520806 ~ 46613836) to Ensembl
Sequene Features : Isoforms 1, Variants 120, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cellular response to hypoxia
.regulation of transcription from RNA polymerase II promoter in response to hypoxia
.iron ion homeostasis
  + 18 more...
.protein heterodimerization activity
.histone acetyltransferase binding
.transcription factor binding
  + 4 more...
.nuclear speck
.cytosol
.transcription factor complex
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 120 4
2014-09-19protein level
1 99 4
2014-05-27protein level
1 99 4
2014-02-25protein level
1 99 4
2013-12-09protein level
1 79 4
2013-11-01protein level
1 74 4
2013-09-12protein level
1 74 4
2013-08-17protein level
1 74 4
2013-07-15protein level
1 56 4
2013-06-11protein level
1 56 4
2013-02-12protein level
1 37 4
2012-12-20protein level
1 37 4
2012-10-30protein level
1 38 4
2012-10-07protein level
1 38 4
2012-08-24protein level
1 36 4
2012-07-28protein level
1 36 4
2012-06-08protein level
1 47 4
2012-05-07protein level
1 37 4
2012-04-10protein level
1 33 4
2012-01-13protein level
1 27 4
2011-12-20protein level
1 27 4
2011-11-11protein level
1 27 4
2011-08-23protein level
1 27 4
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q99814-1
32 0 0 96396.9236
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-447470,EBI-298336 SP1  
  .definitive hemopoiesis
.embryonic process involved in female pregnancy
.embryonic skeletal system development
  + 19 more...
.HMG box domain binding
.metal ion binding
.transcription regulatory region DNA binding
  + 16 more...
.protein-DNA complex
.cytoplasm
.nucleoplasm
.nucleus
2 EBI-447470,EBI-1050865 USP8  
  .protein K48-linked deubiquitination
.protein K63-linked deubiquitination
.regulation of proteasomal protein catabolic process
  + 6 more...
.ubiquitin-specific protease activity
.cysteine-type endopeptidase activity
.extrinsic component of endosome membrane
.midbody
.extrinsic component of plasma membrane
  + 6 more...
3 EBI-447470,EBI-347740 EIF3E  
  .negative regulation of translational initiation
.cellular protein metabolic process
.gene expression
  + 5 more...
.protein N-terminus binding
.poly(A) RNA binding
.translation initiation factor activity
.extracellular exosome
.eukaryotic 48S preinitiation complex
.PML body
  + 7 more...
4 EBI-447470,EBI-751711 MAX  
  .cellular response to peptide hormone stimulus
.retina development in camera-type eye
.neuron apoptotic process
  + 6 more...
.sequence-specific DNA binding
.transcription coactivator activity
.transcription cofactor activity
.sequence-specific DNA binding transcription factor activity
.MLL1 complex
.dendrite
.PML body
  + 3 more...
5 EBI-447470,EBI-347161 SMAD3  
  .positive regulation of extracellular matrix assembly
.activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
.extrinsic apoptotic signaling pathway
  + 73 more...
.R-SMAD binding
.co-SMAD binding
.transcription regulatory region DNA binding
  + 21 more...
.SMAD2-SMAD3 protein complex
.SMAD protein complex
.receptor complex
  + 8 more...
6 EBI-447470,EBI-1805814 BBS4  
  .protein localization to centrosome
.protein localization to cilium
.regulation of cilium beat frequency involved in ciliary motility
  + 37 more...
.beta-tubulin binding
.alpha-tubulin binding
.dynactin binding
  + 2 more...
.ciliary membrane
.ciliary basal body
.ciliary transition zone
  + 9 more...
7 EBI-447470,EBI-1174818 EGLN1  
  .response to nitric oxide
.cellular response to hypoxia
.regulation of transcription from RNA polymerase II promoter in response to hypoxia
  + 11 more...
.peptidyl-proline 4-dioxygenase activity
.peptidyl-proline dioxygenase activity
.L-ascorbic acid binding
  + 3 more...
.cytosol
.cytoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue621
adrenal gland121
ascites100
bladder267
blood8
bone265
bone marrow41
brain157
cervix103
connective tissue234
ear124
embryonic tissue65
eye181
heart256
intestine120
kidney109
liver141
lung415
lymph45
lymph node11
mammary gland52
mouth211
muscle65
nerve257
ovary68
pancreas163
parathyroid679
pharynx49
pituitary gland60
placenta985
prostate100
salivary gland394
skin142
spleen93
stomach83
testis103
thymus62
thyroid193
trachea1139
umbilical cord72
uterus211
vascular174
Health State
TissuesTPM*
normal245
bladder carcinoma56
breast (mammary gland) tumor42
cervical tumor115
chondrosarcoma398
colorectal tumor106
gastrointestinal tumor84
germ cell tumor34
glioma177
head and neck tumor216
kidney tumor87
liver tumor135
lung tumor175
lymphoma41
non-neoplasia155
ovarian tumor118
pancreatic tumor66
primitive neuroectodermal tumor of the CNS39
retinoblastoma43
skin tumor47
soft tissue/muscle tissue tumor47
uterine tumor44
Developmental Stage
TissuesTPM*
adult282
embryoid body85
neonate64
fetus149
infant42
juvenile53
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue243.6
adrenal gland60.3
appendix64.4
bone marrow2.3
cerebral cortex48.4
colon71
duodenum41.9
esophagus76.9
gallbladder107.1
heart muscle109.2
kidney96.9
liver83.2
lung422.7
lymph node59.9
ovary35.4
pancreas30.1
placenta435.9
prostate48.7
salivary gland30.6
skin41.3
small intestine42.5
spleen82.3
stomach44.1
testis31.4
thyroid gland145.5
urinary bladder100.4
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*603349, gene) Endothelial pas domain protein 1; EPAS1OMIM
2(#611783, phenotype) Erythrocytosis, familial, 4; ECYT4OMIM


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