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> Protein (NX_Q99816)
Protein (NX_Q99816)
Protein
Gene SymbolTSG101 to neXtProt (NX_Q99816)
DescriptionTumor susceptibility gene 101 protein
Chromosome11
Location11p15.1 (18489883 ~ 18548779) to Ensembl
Sequene Features : Isoforms 2, Variants 39, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of viral budding via host ESCRT complex
.regulation of viral budding via host ESCRT complex
.regulation of extracellular exosome assembly
  + 21 more...
.calcium-dependent protein binding
.virion binding
.ubiquitin binding
  + 4 more...
.extracellular exosome
.late endosome membrane
.endosome membrane
  + 8 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 39 3
2014-09-19protein level
2 29 3
2014-05-27protein level
2 29 3
2014-02-25protein level
2 28 3
2013-12-09protein level
2 23 3
2013-11-01protein level
2 23 2
2013-09-12protein level
2 23 2
2013-08-17protein level
2 23 2
2013-07-15protein level
2 16 0
2013-06-11protein level
2 16 0
2013-02-12protein level
2 9 6
2012-12-20protein level
2 9 6
2012-10-30protein level
2 10 6
2012-10-07protein level
2 10 3
2012-08-24protein level
2 4 3
2012-07-28protein level
2 4 3
2012-06-08protein level
2 16 3
2012-05-07protein level
2 16 3
2012-04-10protein level
2 16 3
2012-01-13protein level
2 18 3
2011-12-20protein level
2 18 3
2011-11-11protein level
2 18 3
2011-08-23protein level
2 18 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q99816-1
6 10 0 43916.3311
NX_Q99816-2
1 10 0 31712.0896
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-346882,EBI-2559305 VPS37C  
  .intracellular transport of virus
.membrane organization
.viral protein processing
  + 5 more...
.calcium-dependent protein binding .extracellular exosome
.late endosome membrane
.endosome membrane
.ESCRT I complex
2 EBI-346882,EBI-2129851 MGRN1  
  .negative regulation of G-protein coupled receptor protein signaling pathway
.negative regulation of cAMP-mediated signaling
.endosome to lysosome transport
  + 2 more...
.ligase activity
.zinc ion binding
.ubiquitin-protein transferase activity
.extracellular exosome
.membrane
.plasma membrane
  + 4 more...
3 EBI-346882,EBI-297509 IQGAP1  
  .neuron projection extension
.glomerular visceral epithelial cell development
.positive regulation of protein serine/threonine kinase activity
  + 16 more...
.protein serine/threonine kinase activator activity
.protein phosphatase binding
.protein kinase binding
  + 5 more...
.extracellular exosome
.neuron projection
.cytoplasmic ribonucleoprotein granule
  + 15 more...
4 EBI-346882,EBI-876651 ROCK1  
  .regulation of cell motility
.regulation of establishment of cell polarity
.positive regulation of focal adhesion assembly
  + 27 more...
.metal ion binding
.ATP binding
.protein serine/threonine kinase activity
.protein kinase activity
.bleb
.lamellipodium
.plasma membrane
  + 5 more...
5 EBI-346882,EBI-948001 KRT31  
  .epidermis development .structural constituent of cytoskeleton .extracellular exosome
.intermediate filament
.extracellular space
6 EBI-346882,EBI-747776 CEP55  
  .establishment of protein localization
.mitotic nuclear division
.cell separation after cytokinesis
.mitotic cytokinesis
.N/A .intercellular bridge
.cleavage furrow
.midbody
  + 3 more...
7 EBI-346882,EBI-720984 LRSAM1  
  .ubiquitin-dependent endocytosis
.protein autoubiquitination
.viral budding
  + 3 more...
.ligase activity
.zinc ion binding
.ubiquitin-protein transferase activity
.membrane
.cytoplasm
.extracellular region
8 EBI-346882,EBI-529518 TAX1BP1  
  .innate immune response
.negative regulation of apoptotic process
.negative regulation of type I interferon production
  + 2 more...
.metal ion binding
.kinase binding
.extracellular exosome
.cytosol
9 EBI-346882,EBI-10175124 FAM9B  
  .spermatid development .N/A .nucleoplasm
10 EBI-346882,EBI-6872807 SYCE1  
  .cell division
.synaptonemal complex assembly
.N/A .central element
11 EBI-346882,EBI-739895 USHBP1  
  .N/A .PDZ domain binding .N/A
12 EBI-346882,EBI-2850578 VPS37A  
  .intracellular transport of virus
.membrane organization
.ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
  + 6 more...
.N/A .intracellular membrane-bounded organelle
.late endosome membrane
.endosome membrane
  + 4 more...
13 EBI-346882,EBI-2514791 HAUS1  
  .cell division
.centrosome organization
.spindle assembly
.mitotic nuclear division
.N/A .HAUS complex
.microtubule
.centrosome
  + 2 more...
14 EBI-346882,EBI-725647 LITAF  
  .cellular response to lipopolysaccharide
.positive regulation of I-kappaB kinase/NF-kappaB signaling
.negative regulation of NF-kappaB import into nucleus
  + 6 more...
.WW domain binding
.signal transducer activity
.intracellular membrane-bounded organelle
.plasma membrane
.Golgi apparatus
  + 3 more...
15 EBI-346882,EBI-2125614 KIFC3  
  .epithelial cell-cell adhesion
.zonula adherens maintenance
.metabolic process
  + 3 more...
.ATPase activity
.ATP binding
.microtubule motor activity
.extracellular exosome
.cytoplasmic vesicle membrane
.zonula adherens
  + 4 more...
16 EBI-346882,EBI-724478 PTPN23  
  .positive regulation of early endosome to late endosome transport
.positive regulation of adherens junction organization
.positive regulation of homophilic cell adhesion
  + 5 more...
.protein kinase binding
.protein tyrosine phosphatase activity
.extracellular exosome
.ciliary basal body
.cytoplasmic membrane-bounded vesicle
  + 5 more...
17 EBI-346882,EBI-350517 PDLIM7  
  .positive regulation of osteoblast differentiation
.cell differentiation
.actin cytoskeleton organization
  + 3 more...
.zinc ion binding .actin cytoskeleton
.focal adhesion
.cytoplasm
  + 3 more...
18 EBI-346882,EBI-77321 DAXX  
  .positive regulation of apoptotic signaling pathway
.positive regulation of neuron death
.negative regulation of transcription, DNA-templated
  + 13 more...
.androgen receptor binding
.protein N-terminus binding
.protein homodimerization activity
  + 10 more...
.SWI/SNF superfamily-type complex
.PML body
.cytosol
  + 5 more...
19 EBI-346882,EBI-727424 VPS28  
  .positive regulation of ubiquitin-dependent endocytosis
.intracellular transport of virus
.membrane organization
  + 9 more...
.ubiquitin binding
.protein complex binding
.extracellular exosome
.late endosome membrane
.endosome membrane
  + 6 more...
20 EBI-346882,EBI-298152 CD2AP  
  .regulation of actin cytoskeleton reorganization
.positive regulation of protein localization to nucleus
.cell division
  + 5 more...
.SH3 domain binding
.structural constituent of cytoskeleton
.extracellular exosome
.filamentous actin
.actin cytoskeleton
  + 5 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
adrenal gland30
ascites175
bladder66
blood261
bone97
bone marrow184
brain53
cervix103
connective tissue87
ear124
embryonic tissue70
eye62
heart67
intestine60
kidney109
liver97
lung65
lymph22
lymph node100
mammary gland66
muscle65
nerve64
ovary137
pancreas98
parathyroid97
pharynx73
pituitary gland968
placenta84
prostate58
salivary gland49
skin75
stomach73
testis55
thymus25
thyroid42
tonsil58
uterus81
vascular116
Health State
TissuesTPM*
normal78
adrenal tumor79
breast (mammary gland) tumor107
cervical tumor86
chondrosarcoma84
colorectal tumor44
gastrointestinal tumor75
germ cell tumor26
glioma74
head and neck tumor22
kidney tumor58
leukemia95
liver tumor156
lung tumor68
lymphoma166
non-neoplasia62
ovarian tumor144
pancreatic tumor66
primitive neuroectodermal tumor of the CNS94
prostate cancer38
retinoblastoma64
skin tumor31
soft tissue/muscle tissue tumor87
uterine tumor110
Developmental Stage
TissuesTPM*
adult90
embryoid body71
blastocyst48
neonate160
fetus73
infant212
juvenile89
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue39.2
adrenal gland65.4
appendix39.4
bone marrow59.1
cerebral cortex35.9
colon55.9
duodenum47.1
esophagus65.5
gallbladder50.6
heart muscle64.2
kidney54.5
liver31.4
lung49.2
lymph node49.1
ovary56.5
pancreas28.8
placenta72.3
prostate39.9
salivary gland38.7
skin40.2
small intestine42.8
spleen36.6
stomach43.7
testis65.9
thyroid gland58.2
urinary bladder53.7
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowMedium
breastHigh
bronchusHigh
cerebellumMedium
cerebral cortexMedium
cervix, uterineHigh
colonMedium
duodenumMedium
endometrium 1High
endometrium 2High
epididymisMedium
esophagusMedium
fallopian tubeHigh
gallbladderMedium
heart muscleMedium
hippocampusMedium
kidneyHigh
lateral ventricleMedium
liverMedium
lungMedium
lymph nodeMedium
nasopharynxHigh
oral mucosaMedium
ovaryMedium
pancreasMedium
parathyroid glandLow
placentaHigh
prostateMedium
rectumMedium
salivary glandMedium
seminal vesicleMedium
skeletal muscleMedium
skin 1Medium
skin 2High
small intestineMedium
smooth muscleMedium
soft tissue 1Medium
soft tissue 2Low
spleenMedium
stomach 1High
stomach 2Medium
testisHigh
thyroid glandHigh
tonsilHigh
urinary bladderHigh
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*601387, gene) Tumor susceptibility gene 101; TSG101OMIM


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2014-2019 (C) Yonsei Proteome Research Center