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> Protein (NX_Q99836)
Protein (NX_Q99836)
Protein
Gene SymbolMYD88 to neXtProt (NX_Q99836)
DescriptionMyeloid differentiation primary response protein MyD88
Chromosome3
Location3p22.2 (38179969 ~ 38184513) to Ensembl
Sequene Features : Isoforms 6, Variants 56, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cellular response to mechanical stimulus
.3'-UTR-mediated mRNA stabilization
.response to interleukin-1
  + 22 more...
.TIR domain binding
.identical protein binding
.death receptor binding
.endosome membrane
.plasma membrane
.cytosol
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
6 56 5
2014-09-19protein level
6 45 5
2014-05-27protein level
6 42 5
2014-02-25protein level
4 41 5
2013-12-09protein level
4 33 5
2013-11-01protein level
4 32 5
2013-09-12protein level
4 32 5
2013-08-17protein level
4 32 5
2013-07-15protein level
4 25 1
2013-06-11protein level
4 25 1
2013-02-12protein level
4 19 0
2012-12-20protein level
4 17 0
2012-10-30protein level
4 22 0
2012-10-07protein level
4 22 0
2012-08-24protein level
4 21 0
2012-07-28protein level
4 21 0
2012-06-08protein level
4 28 0
2012-05-07protein level
4 14 0
2012-04-10protein level
2 14 0
2012-01-13protein level
2 14 0
2011-12-20protein level
2 14 0
2011-11-11protein level
2 14 0
2011-08-23protein level
2 14 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q99836-1
0 14 0 33211.9497
NX_Q99836-2
1 11 0 28261.4828
NX_Q99836-3
1 8 0 20763.6824
NX_Q99836-4
1 6 0 15813.2155
NX_Q99836-5
0 13 0 31476.0806
NX_Q99836-6
0 14 0 34075.4669
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-447677,EBI-519160 TNFRSF13B  
  .negative regulation of B cell proliferation
.cell surface receptor signaling pathway
.hematopoietic progenitor cell differentiation
.B cell homeostasis
.receptor activity .external side of plasma membrane
.integral component of plasma membrane
2 EBI-447677,EBI-743549 SPOP  
  .positive regulation of type B pancreatic cell apoptotic process
.positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
.proteasome-mediated ubiquitin-dependent protein catabolic process
  + 2 more...
.ubiquitin protein ligase binding .Cul3-RING ubiquitin ligase complex
.nuclear speck
.nucleoplasm
.nucleus
3 EBI-447677,EBI-594644 TXN  
  .negative regulation of hydrogen peroxide-induced cell death
.oxidation-reduction process
.nucleobase-containing small molecule metabolic process
  + 23 more...
.poly(A) RNA binding
.oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor
.peptide disulfide oxidoreductase activity
.protein disulfide oxidoreductase activity
.extracellular exosome
.cytosol
.mitochondrion
  + 3 more...
4 EBI-447677,EBI-358664 IRAK1  
  .cellular response to hypoxia
.response to interleukin-1
.interleukin-1-mediated signaling pathway
  + 39 more...
.protein heterodimerization activity
.protein homodimerization activity
.kinase activity
  + 5 more...
.interleukin-1 receptor complex
.endosome membrane
.plasma membrane
  + 4 more...
5 EBI-447677,EBI-528644 TIRAP  
  .positive regulation of chemokine (C-X-C motif) ligand 2 production
.positive regulation of chemokine (C-X-C motif) ligand 1 production
.positive regulation of protein homodimerization activity
  + 34 more...
.protein heterodimerization activity
.protein homodimerization activity
.Toll-like receptor 2 binding
  + 4 more...
.intercellular bridge
.ruffle membrane
.endocytic vesicle
  + 4 more...
6 EBI-447677,EBI-347161 SMAD3  
  .positive regulation of extracellular matrix assembly
.activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
.extrinsic apoptotic signaling pathway
  + 73 more...
.R-SMAD binding
.co-SMAD binding
.transcription regulatory region DNA binding
  + 21 more...
.SMAD2-SMAD3 protein complex
.SMAD protein complex
.receptor complex
  + 8 more...
7 EBI-447677,EBI-494804 FADD  
  .positive regulation of extrinsic apoptotic signaling pathway
.positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation
.positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
  + 49 more...
.identical protein binding
.death effector domain binding
.tumor necrosis factor receptor superfamily binding
  + 2 more...
.ripoptosome
.membrane raft
.cell body
  + 4 more...
8 EBI-447677,EBI-747107 SIAH1  
  .positive regulation of intrinsic apoptotic signaling pathway
.neuron apoptotic process
.proteasome-mediated ubiquitin-dependent protein catabolic process
  + 11 more...
.ubiquitin protein ligase activity
.identical protein binding
.ligase activity
  + 3 more...
.beta-catenin destruction complex
.plasma membrane
.cytosol
  + 3 more...
9 EBI-447677,EBI-2548605 DOCK8  
  .negative regulation of T cell apoptotic process
.memory T cell proliferation
.dendritic cell migration
  + 3 more...
.guanyl-nucleotide exchange factor activity .cell leading edge
.membrane
.cytosol
10 EBI-447677,EBI-302474 USP7  
  .regulation of proteasomal protein catabolic process
.regulation of sequence-specific DNA binding transcription factor activity
.proteasome-mediated ubiquitin-dependent protein catabolic process
  + 7 more...
.ubiquitin protein ligase binding
.transcription factor binding
.protein C-terminus binding
  + 3 more...
.PML body
.nuclear body
.cytosol
.nucleus
11 EBI-447677,EBI-1553984 STAP2  
  .N/A .N/A .plasma membrane
.cytoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland182
ascites100
bladder167
blood613
bone13
bone marrow266
brain67
cervix103
connective tissue60
ear186
embryonic tissue51
esophagus99
eye71
heart89
intestine150
kidney137
larynx42
liver87
lung101
lymph22
lymph node66
mammary gland132
mouth498
muscle84
ovary49
pancreas60
pharynx98
pituitary gland60
placenta77
prostate58
salivary gland49
skin118
spleen543
stomach324
testis32
thymus451
thyroid85
trachea115
umbilical cord217
uterus129
vascular251
Health State
TissuesTPM*
normal112
bladder carcinoma113
breast (mammary gland) tumor171
cervical tumor115
chondrosarcoma72
colorectal tumor97
esophageal tumor115
gastrointestinal tumor244
germ cell tumor72
glioma55
head and neck tumor254
kidney tumor58
leukemia243
liver tumor104
lung tumor19
lymphoma55
non-neoplasia82
ovarian tumor39
pancreatic tumor85
primitive neuroectodermal tumor of the CNS55
prostate cancer9
retinoblastoma21
skin tumor39
soft tissue/muscle tissue tumor31
uterine tumor55
Developmental Stage
TissuesTPM*
adult94
embryoid body42
blastocyst81
neonate579
fetus84
infant42
juvenile161
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue21.8
adrenal gland13.6
appendix51.2
bone marrow55
cerebral cortex6.3
colon32.8
duodenum33.1
esophagus31.6
gallbladder29
heart muscle6.5
kidney12.9
liver29.9
lung38.6
lymph node41.5
ovary13.2
pancreas6.6
placenta20.9
prostate13.3
salivary gland11.4
skin18.7
small intestine32.9
spleen47.9
stomach31.4
testis11.2
thyroid gland9.8
urinary bladder38.8
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*602170, gene) Myeloid differentiation primary response gene 88; MYD88OMIM
2(#612260, phenotype) Myd88 deficiency; MYD88DOMIM
3ABC-DLBCLCGP


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