Home| Contact Us

HOME SEARCH STATISTICS
> Protein (NX_Q99942)
Protein (NX_Q99942)
Protein
Gene SymbolRNF5 to neXtProt (NX_Q99942)
DescriptionE3 ubiquitin-protein ligase RNF5
Chromosome6
Location6p21.32 (32146131 ~ 32151930) to Ensembl
Sequene Features : Isoforms 1, Variants 15, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of autophagic vacuole assembly
.ER-associated misfolded protein catabolic process
.protein K48-linked ubiquitination
  + 5 more...
.ligase activity
.zinc ion binding
.ubiquitin-protein transferase activity
.mitochondrial membrane
.integral component of membrane
.endoplasmic reticulum membrane
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 15 5
2014-09-19protein level
1 13 5
2014-05-27protein level
1 14 5
2014-02-25protein level
1 3 5
2013-12-09protein level
1 2 5
2013-11-01protein level
1 2 3
2013-09-12protein level
1 2 3
2013-08-17protein level
1 2 3
2013-07-15protein level
1 2 0
2013-06-11protein level
1 2 0
2013-02-12protein level
1 2 1
2012-12-20protein level
1 2 1
2012-10-30protein level
1 3 1
2012-10-07protein level
1 3 1
2012-08-24protein level
1 3 1
2012-07-28protein level
1 3 1
2012-06-08protein level
1 8 1
2012-05-07protein level
1 8 1
2012-04-10protein level
1 8 1
2012-01-13protein level
1 9 1
2011-12-20protein level
1 9 1
2011-11-11protein level
1 9 1
2011-08-23protein level
1 9 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q99942-1
7 0 0 19868.615
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-348482,EBI-348517 ABHD16A  
  .N/A .hydrolase activity .integral component of membrane
2 EBI-348482,EBI-349854 CFTR  
  .positive regulation of voltage-gated chloride channel activity
.chloride transmembrane transport
.cellular response to cAMP
  + 20 more...
.PDZ domain binding
.enzyme binding
.chloride channel inhibitor activity
  + 6 more...
.extracellular exosome
.recycling endosome
.protein complex
  + 11 more...
3 EBI-348482,EBI-745376 SLC1A1  
  .cysteine transmembrane transport
.L-glutamate transmembrane transport
.D-aspartate import
  + 8 more...
.cysteine transmembrane transporter activity
.sodium:dicarboxylate symporter activity
.glutamate binding
  + 2 more...
.extracellular exosome
.apical plasma membrane
.membrane
  + 2 more...
4 EBI-348482,EBI-702209 PXN  
  .growth hormone receptor signaling pathway
.branching morphogenesis of an epithelial tube
.focal adhesion assembly
  + 16 more...
.vinculin binding
.zinc ion binding
.beta-catenin binding
.lamellipodium
.cell cortex
.focal adhesion
  + 6 more...
5 EBI-348482,EBI-8646596 CYB561  
  .transmembrane transport
.electron transport chain
.metal ion binding
.transmembrane electron transfer carrier
.ferric-chelate reductase activity
.integral component of membrane
6 EBI-348482,EBI-743540 UBE2D1  
  .cellular response to hypoxia
.protein K48-linked ubiquitination
.regulation of transcription from RNA polymerase II promoter in response to hypoxia
  + 22 more...
.ubiquitin conjugating enzyme activity
.ligase activity
.ATP binding
.ubiquitin-protein transferase activity
.protein complex
.cytosol
.cytoplasm
  + 2 more...
7 EBI-348482,EBI-348268 UBE2D3  
  .positive regulation of protein targeting to mitochondrion
.cellular response to hypoxia
.protein K11-linked ubiquitination
  + 24 more...
.ubiquitin conjugating enzyme activity
.ligase activity
.ATP binding
.ubiquitin-protein transferase activity
.extracellular exosome
.endosome membrane
.plasma membrane
  + 2 more...
8 EBI-348482,EBI-473850 UBE2K  
  .protein K48-linked ubiquitination
.intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
.proteasome-mediated ubiquitin-dependent protein catabolic process
  + 2 more...
.ubiquitin protein ligase activity
.ubiquitin-ubiquitin ligase activity
.ubiquitin protein ligase binding
  + 4 more...
.extracellular exosome
.intermediate filament cytoskeleton
.actin cytoskeleton
  + 2 more...
9 EBI-348482,EBI-347677 UBE2D2  
  .cellular response to hypoxia
.protein K48-linked ubiquitination
.regulation of transcription from RNA polymerase II promoter in response to hypoxia
  + 12 more...
.ubiquitin conjugating enzyme activity
.ligase activity
.ATP binding
.ubiquitin-protein transferase activity
.extracellular exosome
.protein complex
.cytosol
  + 2 more...
10 EBI-348482,EBI-10269179 CYB561A3  
  .N/A .metal ion binding
.oxidoreductase activity
.late endosome membrane
.integral component of membrane
.lysosomal membrane
11 EBI-348482,EBI-348496 UBE2E3  
  .protein K11-linked ubiquitination
.protein K48-linked ubiquitination
.protein K63-linked ubiquitination
.regulation of growth
.ligase activity
.ATP binding
.ubiquitin-protein transferase activity
.cytoplasm
.nucleus
12 EBI-348482,EBI-716589 UBE2W  
  .cellular response to misfolded protein
.protein K11-linked ubiquitination
.proteasome-mediated ubiquitin-dependent protein catabolic process
  + 3 more...
.ubiquitin protein ligase activity
.ubiquitin protein ligase binding
.ubiquitin-like protein transferase activity
  + 3 more...
.cytoplasm
.nucleus
13 EBI-348482,EBI-2340249 RNF185  
  .protein ubiquitination
.autophagy
.ligase activity
.zinc ion binding
.integral component of membrane
.endoplasmic reticulum membrane
.mitochondrial outer membrane
14 EBI-348482,EBI-8652744 SEC22A  
  .vesicle fusion with Golgi apparatus
.protein transport
.ER to Golgi vesicle-mediated transport
.SNAP receptor activity
.transporter activity
.SNARE binding
.SNARE complex
.integral component of membrane
.endoplasmic reticulum membrane
15 EBI-348482,EBI-2129763 UBE2E2  
  .positive regulation of G1/S transition of mitotic cell cycle
.protein K11-linked ubiquitination
.protein K48-linked ubiquitination
  + 3 more...
.ubiquitin conjugating enzyme activity
.ISG15 transferase activity
.ligase activity
  + 2 more...
.N/A
16 EBI-348482,EBI-751204 YIPF2  
  .N/A .N/A .transport vesicle
.integral component of membrane
17 EBI-348482,EBI-10314552 SLC38A7  
  .L-aspartate transmembrane transport
.L-glutamate transmembrane transport
.L-histidine transmembrane transport
  + 10 more...
.L-serine transmembrane transporter activity
.L-methionine transmembrane transporter activity
.L-leucine transmembrane transporter activity
  + 7 more...
.neuronal cell body
.axon
.integral component of membrane
18 EBI-348482,EBI-10315004 TMEM242  
  .N/A .N/A .integral component of membrane
19 EBI-348482,EBI-745527 UBE2D4  
  .protein K6-linked ubiquitination
.protein K11-linked ubiquitination
.protein K48-linked ubiquitination
  + 4 more...
.ubiquitin conjugating enzyme activity
.ligase activity
.ATP binding
.ubiquitin-protein transferase activity
.N/A
20 EBI-348482,EBI-8503746 INSIG2  
  .response to fatty acid
.cranial suture morphogenesis
.palate development
  + 9 more...
.N/A .SREBP-SCAP-Insig complex
.endoplasmic reticulum membrane
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland60
ascites100
blood24
bone marrow41
brain22
cervix61
connective tissue40
embryonic tissue42
esophagus99
eye86
heart33
intestine68
kidney14
liver63
lung53
lymph node33
mammary gland33
muscle75
nerve64
ovary108
pancreas23
pharynx24
placenta17
prostate36
salivary gland49
skin9
spleen56
stomach52
testis27
thymus37
uterus51
Health State
TissuesTPM*
normal34
breast (mammary gland) tumor42
chondrosarcoma48
colorectal tumor35
esophageal tumor115
gastrointestinal tumor59
germ cell tumor18
glioma37
head and neck tumor7
kidney tumor43
leukemia63
liver tumor41
lung tumor68
non-neoplasia41
ovarian tumor105
pancreatic tumor9
primitive neuroectodermal tumor of the CNS39
prostate cancer48
retinoblastoma129
skin tumor7
soft tissue/muscle tissue tumor23
uterine tumor88
Developmental Stage
TissuesTPM*
adult39
embryoid body28
blastocyst48
fetus61
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue15.2
adrenal gland28
appendix15.6
bone marrow17.4
cerebral cortex20.9
colon31.7
duodenum31.4
esophagus14.2
gallbladder21.5
heart muscle28.7
kidney45.7
liver33.3
lung22.6
lymph node21.5
ovary26.1
pancreas8.8
placenta17
prostate24.8
salivary gland17.7
skin17
small intestine32.3
spleen17
stomach21.1
testis14.7
thyroid gland20.7
urinary bladder19.3
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*602677, gene) Ring finger protein 5; RNF5OMIM


#424, YPRC/BPRC, Industry-University Research Center, Yonsei Univ., Seodaemun-gu, Seoul, Korea, 120-749
Tel: +82-2-2123-6626, Fax: +82-2-393-6589
2014-2019 (C) Yonsei Proteome Research Center