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> Protein (NX_Q99952)
Protein (NX_Q99952)
Protein
Gene SymbolPTPN18 to neXtProt (NX_Q99952)
DescriptionTyrosine-protein phosphatase non-receptor type 18
Chromosome2
Location2q21.1 (131113580 ~ 131132982) to Ensembl
Sequene Features : Isoforms 2, Variants 61, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.peptidyl-tyrosine dephosphorylation
.protein dephosphorylation
.non-membrane spanning protein tyrosine phosphatase activity .cytoplasm
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 61 2
2014-09-19protein level
2 51 2
2014-05-27protein level
2 51 2
2014-02-25protein level
2 51 2
2013-12-09protein level
2 43 2
2013-11-01protein level
2 42 2
2013-09-12protein level
2 42 2
2013-08-17protein level
2 42 2
2013-07-15protein level
2 30 2
2013-06-11protein level
2 30 2
2013-02-12protein level
2 20 6
2012-12-20protein level
2 19 6
2012-10-30protein level
2 21 6
2012-10-07protein level
2 21 3
2012-08-24protein level
2 21 3
2012-07-28protein level
2 20 3
2012-06-08protein level
2 22 3
2012-05-07protein level
2 19 3
2012-04-10protein level
2 19 3
2012-01-13protein level
1 11 3
2011-12-20protein level
1 11 3
2011-11-11protein level
1 11 3
2011-08-23protein level
1 11 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q99952-1
6 17 0 50450.3074
NX_Q99952-2
1 17 0 38451.2486
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1384210,EBI-1050964 PSTPIP1  
  .innate immune response
.nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
.signal transduction
  + 3 more...
.N/A .perinuclear region of cytoplasm
.cleavage furrow
.lamellipodium
  + 5 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland60
ascites25
blood24
bone97
brain3
cervix20
connective tissue46
esophagus49
eye33
heart78
intestine4
kidney4
larynx42
liver4
lung8
lymph22
lymph node22
mammary gland6
mouth15
muscle18
nerve193
ovary88
pancreas51
pharynx122
placenta7
prostate84
skin28
spleen393
stomach41
testis6
thymus25
thyroid42
tonsil58
trachea57
uterus56
Health State
TissuesTPM*
normal4
adrenal tumor79
breast (mammary gland) tumor150
cervical tumor28
chondrosarcoma84
colorectal tumor8
esophageal tumor57
gastrointestinal tumor33
germ cell tumor15
glioma55
head and neck tumor7
kidney tumor43
leukemia52
liver tumor10
lung tumor19
lymphoma13
non-neoplasia62
ovarian tumor78
pancreatic tumor66
primitive neuroectodermal tumor of the CNS31
prostate cancer28
retinoblastoma64
skin tumor31
soft tissue/muscle tissue tumor23
uterine tumor66
Developmental Stage
TissuesTPM*
adult9
neonate32
fetus7
juvenile161
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue34.5
adrenal gland19.8
appendix56.2
bone marrow41.3
cerebral cortex16.2
colon50.1
duodenum37.6
esophagus19
gallbladder37.7
heart muscle13.5
kidney26.4
liver14.3
lung38.6
lymph node83.9
ovary20.8
pancreas15.8
placenta25.5
prostate38.2
salivary gland39.8
skin16.6
small intestine41.3
spleen66.2
stomach45.7
testis10.4
thyroid gland31.4
urinary bladder37.4
Tissues
TissuesExpression level
adrenal glandMedium
appendixHigh
bone marrowMedium
breastLow
bronchusMedium
cerebellumMedium
cerebral cortexLow
cervix, uterineMedium
colonHigh
duodenumHigh
endometrium 1Medium
endometrium 2Medium
esophagusLow
fallopian tubeMedium
gallbladderLow
heart muscleHigh
hippocampusLow
kidneyMedium
lateral ventricleLow
liverMedium
lungMedium
lymph nodeLow
oral mucosaLow
ovaryMedium
pancreasMedium
parathyroid glandLow
placentaMedium
rectumHigh
salivary glandMedium
skeletal muscleMedium
skin 1Medium
skin 2Medium
small intestineHigh
smooth muscleMedium
soft tissue 1Medium
soft tissue 2Medium
spleenMedium
stomach 1Low
stomach 2Low
testisMedium
thyroid glandMedium
tonsilLow
urinary bladderMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*606587, gene) Protein-tyrosine phosphatase, nonreceptor-type, 18; PTPN18OMIM


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