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> Protein (NX_Q99958)
Protein (NX_Q99958)
Protein
Gene SymbolFOXC2 to neXtProt (NX_Q99958)
DescriptionForkhead box protein C2
Chromosome16
Location16q24.1 (86600857 ~ 86602539) to Ensembl
Sequene Features : Isoforms 1, Variants 59, PTMs 12 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of apoptotic process involved in outflow tract morphogenesis
.positive regulation of cell migration involved in sprouting angiogenesis
.glomerular mesangial cell development
  + 34 more...
.transcription regulatory region DNA binding
.sequence-specific DNA binding
.chromatin DNA binding
  + 3 more...
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 59 12
2014-09-19protein level
1 49 12
2014-05-27protein level
1 49 12
2014-02-25protein level
1 48 12
2013-12-09protein level
1 35 12
2013-11-01protein level
1 34 12
2013-09-12protein level
1 34 10
2013-08-17protein level
1 34 10
2013-07-15protein level
1 26 10
2013-06-11protein level
1 26 10
2013-02-12protein level
1 8 8
2012-12-20protein level
1 7 8
2012-10-30protein level
1 8 8
2012-10-07protein level
1 8 8
2012-08-24protein level
1 8 8
2012-07-28protein level
1 8 8
2012-06-08protein level
1 9 8
2012-05-07protein level
1 6 8
2012-04-10protein level
1 6 8
2012-01-13protein level
1 5 8
2011-12-20protein level
1 5 8
2011-11-11protein level
1 5 8
2011-08-23protein level
1 5 8
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q99958-1
14 0 4 53685.3307
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-3956892,EBI-719493 TRIM27  
  .negative regulation of viral release from host cell
.negative regulation of interleukin-2 secretion
.negative regulation of calcium ion import
  + 17 more...
.metal ion binding
.ligase activity
.zinc ion binding
  + 4 more...
.nuclear membrane
.PML body
.membrane
  + 6 more...
2 EBI-3956892,EBI-529518 TAX1BP1  
  .innate immune response
.negative regulation of apoptotic process
.negative regulation of type I interferon production
  + 2 more...
.metal ion binding
.kinase binding
.extracellular exosome
.cytosol
3 EBI-3956892,EBI-740322 RBPMS  
  .positive regulation of SMAD protein import into nucleus
.positive regulation of pathway-restricted SMAD protein phosphorylation
.RNA processing
  + 2 more...
.poly(A) RNA binding
.poly(A) binding
.transcription coactivator activity
.nucleotide binding
.cytoplasm
.nucleoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
brain1
ear186
embryonic tissue18
eye14
kidney9
lung8
mammary gland6
pancreas4
uterus4
vascular19
Health State
TissuesTPM*
normal6
pancreatic tumor9
Developmental Stage
TissuesTPM*
adult1
fetus17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
kidney1.8
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Disease
No.Disease DescriptionRef.
1(%153200, phenotype) Lymphedema, hereditary, iiOMIM
2(%153300, phenotype) Yellow nail syndromeOMIM
3(#153400, phenotype) Lymphedema-distichiasis syndromeOMIM
4(*602402, gene) Forkhead box c2; FOXC2OMIM


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