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> Protein (NX_Q99963)
Protein (NX_Q99963)
Protein
Gene SymbolSH3GL3 to neXtProt (NX_Q99963)
DescriptionEndophilin-A3
Chromosome15
Location15q25.2 (84115980 ~ 84287495) to Ensembl
Sequene Features : Isoforms 4, Variants 64, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.central nervous system development
.signal transduction
.endocytosis
.identical protein binding
.lipid binding
.extracellular exosome
.early endosome membrane
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
4 64 2
2014-09-19protein level
4 48 2
2014-05-27protein level
4 48 2
2014-02-25protein level
4 48 2
2013-12-09protein level
4 46 2
2013-11-01protein level
4 44 2
2013-09-12protein level
4 44 2
2013-08-17protein level
4 44 2
2013-07-15protein level
4 26 2
2013-06-11protein level
4 26 2
2013-02-12protein level
4 12 8
2012-12-20protein level
4 12 8
2012-10-30protein level
4 13 8
2012-10-07protein level
4 13 2
2012-08-24protein level
4 11 2
2012-07-28protein level
4 11 2
2012-06-08protein level
4 0 2
2012-05-07protein level
4 0 2
2012-04-10protein level
4 0 2
2012-01-13protein level
4 0 2
2011-12-20protein level
4 0 2
2011-11-11protein level
4 0 2
2011-08-23protein level
4 0 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q99963-1
0 18 0 39259.9137
NX_Q99963-2
0 12 0 31566.903
NX_Q99963-3
2 17 0 40170.2065
NX_Q99963-4
0 17 0 38714.9389
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-473910,EBI-466029 HTT  
  .negative regulation of extrinsic apoptotic signaling pathway
.iron ion homeostasis
.L-glutamate import
  + 38 more...
.diazepam binding
.beta-tubulin binding
.dynein intermediate chain binding
  + 6 more...
.protein complex
.cytoplasmic vesicle membrane
.dendrite
  + 11 more...
2 EBI-473910,EBI-3940924 RAPH1  
  .axon extension
.signal transduction
.cell-matrix adhesion
.N/A .filopodium
.lamellipodium
.plasma membrane
  + 2 more...
3 EBI-473910,EBI-697691 ATXN2  
  .neuromuscular process
.RNA transport
.homeostasis of number of cells
  + 9 more...
.poly(A) RNA binding
.protein C-terminus binding
.epidermal growth factor receptor binding
.RNA binding
.perinuclear region of cytoplasm
.ribonucleoprotein complex
.membrane
  + 6 more...
4 EBI-473910,EBI-697911 SH3GL1  
  .central nervous system development
.signal transduction
.endocytosis
.identical protein binding
.lipid binding
.cell projection
.early endosome membrane
.cell junction
  + 2 more...
5 EBI-473910,EBI-77938 SH3GL2  
  .membrane organization
.synaptic vesicle endocytosis
.neurotrophin TRK receptor signaling pathway
  + 8 more...
.identical protein binding
.lipid binding
.extracellular exosome
.clathrin-coated endocytic vesicle membrane
.plasma membrane
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
brain52
connective tissue26
embryonic tissue4
eye9
heart22
lung8
nerve64
prostate5
testis39
thymus12
Health State
TissuesTPM*
normal18
germ cell tumor3
glioma9
non-neoplasia93
soft tissue/muscle tissue tumor31
Developmental Stage
TissuesTPM*
adult17
embryoid body14
fetus16
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adrenal gland1.1
cerebral cortex36.6
esophagus2.4
kidney1.8
lung4
testis59.6
Tissues
TissuesExpression level
cerebral cortexMedium
pancreasLow
soft tissue 1Low
stomach 1Low
testisMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*603362, gene) Sh3 domain, grb2-like, 3; SH3GL3OMIM


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