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> Protein (NX_Q99986)
Protein (NX_Q99986)
Protein
Gene SymbolVRK1 to neXtProt (NX_Q99986)
DescriptionSerine/threonine-protein kinase VRK1
Chromosome14
Location14q32.2 (97263641 ~ 97398059) to Ensembl
Sequene Features : Isoforms 1, Variants 46, PTMs 10 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.Golgi disassembly
.histone H3-T3 phosphorylation
.cell division
  + 10 more...
.histone kinase activity (H3-T3 specific)
.histone kinase activity (H3-S10 specific)
.nucleosomal histone binding
  + 4 more...
.cytosol
.spindle
.Golgi stack
  + 4 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 46 10
2014-09-19protein level
1 37 10
2014-05-27protein level
1 37 10
2014-02-25protein level
1 37 10
2013-12-09protein level
1 26 10
2013-11-01protein level
1 26 6
2013-09-12protein level
1 26 6
2013-08-17protein level
1 26 6
2013-07-15protein level
1 13 2
2013-06-11protein level
1 13 2
2013-02-12protein level
1 9 2
2012-12-20protein level
1 9 2
2012-10-30protein level
1 12 2
2012-10-07protein level
1 12 2
2012-08-24protein level
1 12 2
2012-07-28protein level
1 12 2
2012-06-08protein level
1 25 2
2012-05-07protein level
1 20 2
2012-04-10protein level
1 20 2
2012-01-13protein level
1 15 2
2011-12-20protein level
1 15 2
2011-11-11protein level
1 13 1
2011-08-23protein level
1 13 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q99986-1
18 0 0 45447.3052
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1769146,EBI-366083 TP53  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of reactive oxygen species metabolic process
.negative regulation of reactive oxygen species metabolic process
  + 99 more...
.protein phosphatase 2A binding
.chaperone binding
.protein N-terminus binding
  + 27 more...
.protein complex
.PML body
.nuclear matrix
  + 11 more...
2 EBI-1769146,EBI-852823 JUN  
  .positive regulation of DNA-templated transcription, initiation
.negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
.cellular response to calcium ion
  + 60 more...
.R-SMAD binding
.poly(A) RNA binding
.transcription regulatory region DNA binding
  + 15 more...
.transcriptional repressor complex
.cytosol
.nuclear euchromatin
  + 4 more...
3 EBI-1769146,EBI-1170906 ATF2  
  .positive regulation of mitochondrial membrane permeability involved in apoptotic process
.adipose tissue development
.stress-activated MAPK cascade
  + 27 more...
.metal ion binding
.cAMP response element binding
.protein kinase binding
  + 13 more...
.site of double-strand break
.mitochondrial outer membrane
.cytoplasm
  + 2 more...
4 EBI-1769146,EBI-945751 COIL  
  .N/A .identical protein binding
.protein C-terminus binding
.membrane
.Cajal body
.cytoplasm
  + 3 more...
5 EBI-1769146,EBI-286642 RAN  
  .protein localization to nucleolus
.intracellular transport of virus
.cell division
  + 21 more...
.androgen receptor binding
.poly(A) RNA binding
.GDP binding
  + 4 more...
.extracellular exosome
.recycling endosome
.RNA nuclear export complex
  + 10 more...
6 EBI-1769146,EBI-396540 TP53BP1  
  .positive regulation of sequence-specific DNA binding transcription factor activity
.positive regulation of transcription from RNA polymerase II promoter
.positive regulation of transcription, DNA-templated
  + 5 more...
.telomeric DNA binding
.methylated histone binding
.damaged DNA binding
  + 3 more...
.cytoplasm
.replication fork
.nucleoplasm
  + 2 more...
7 EBI-1769146,EBI-751877 PLK3  
  .positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia
.positive regulation of intracellular protein transport
.Golgi disassembly
  + 17 more...
.ATP binding
.protein serine/threonine kinase activity
.p53 binding
.neuronal cell body
.dendrite
.centrosome
  + 4 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites50
bladder368
blood89
bone97
bone marrow348
brain17
cervix123
connective tissue308
embryonic tissue56
esophagus49
eye57
heart11
intestine17
kidney4
liver43
lung29
lymph22
lymph node55
mammary gland46
mouth15
muscle37
pharynx147
placenta21
prostate79
salivary gland296
skin28
spleen18
stomach31
testis55
thymus37
trachea38
uterus25
Health State
TissuesTPM*
normal24
bladder carcinoma625
breast (mammary gland) tumor64
cervical tumor115
chondrosarcoma48
colorectal tumor8
esophageal tumor57
gastrointestinal tumor42
germ cell tumor64
glioma18
kidney tumor14
leukemia179
liver tumor72
lung tumor58
lymphoma124
non-neoplasia10
primitive neuroectodermal tumor of the CNS7
prostate cancer134
retinoblastoma107
skin tumor31
soft tissue/muscle tissue tumor391
uterine tumor33
Developmental Stage
TissuesTPM*
adult56
embryoid body14
fetus26
infant42
juvenile125
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue5.3
adrenal gland6.1
appendix16.2
bone marrow45.6
cerebral cortex6.1
colon11.7
duodenum6.8
esophagus8.1
gallbladder4.9
heart muscle5.6
kidney5.6
liver3.1
lung5.2
lymph node27.3
ovary6.8
pancreas2
placenta7.4
prostate5.3
salivary gland3.3
skin7.1
small intestine7.8
spleen11.2
stomach12.7
testis37.2
thyroid gland6.4
urinary bladder8.8
Tissues
TissuesExpression level
adrenal glandLow
appendixLow
bone marrowHigh
breastLow
bronchusMedium
cerebral cortexLow
cervix, uterineLow
duodenumLow
endometrium 1Low
endometrium 2Low
epididymisLow
esophagusLow
gallbladderLow
hippocampusLow
lateral ventricleLow
liverLow
lungLow
lymph nodeMedium
nasopharynxMedium
oral mucosaLow
ovaryLow
pancreasLow
parathyroid glandLow
placentaMedium
skin 1Low
skin 2Low
small intestineLow
spleenMedium
stomach 1Low
stomach 2Low
testisHigh
thyroid glandLow
tonsilMedium
urinary bladderLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*602168, gene) Vaccinia-related kinase 1; VRK1OMIM
2(#607596, phenotype) Pontocerebellar hypoplasia, type 1a; PCH1AOMIM


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