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> Protein (NX_Q9BPX1)
Protein (NX_Q9BPX1)
Protein
Gene SymbolHSD17B14 to neXtProt (NX_Q9BPX1)
Description17-beta-hydroxysteroid dehydrogenase 14
Chromosome19
Location19q13.33 (49316274 ~ 49339935) to Ensembl
Sequene Features : Isoforms 1, Variants 34, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.steroid catabolic process .testosterone 17-beta-dehydrogenase (NADP+) activity
.estradiol 17-beta-dehydrogenase activity
.cytosol
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 34 0
2014-09-19protein level
1 29 0
2014-05-27protein level
1 29 0
2014-02-25protein level
1 29 0
2013-12-09protein level
1 21 0
2013-11-01protein level
1 20 0
2013-09-12protein level
1 20 0
2013-08-17protein level
1 20 0
2013-07-15protein level
1 14 0
2013-06-11protein level
1 14 0
2013-02-12protein level
1 12 0
2012-12-20protein level
1 11 0
2012-10-30protein level
1 15 0
2012-10-07protein level
1 15 0
2012-08-24protein level
1 13 0
2012-07-28protein level
1 13 0
2012-06-08protein level
1 14 0
2012-05-07protein level
1 13 0
2012-04-10protein level
1 13 0
2012-01-13protein level
1 7 0
2011-12-20protein level
1 7 0
2011-11-11protein level
1 7 0
2011-08-23protein level
1 7 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9BPX1-1
14 0 0 28299.5302
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-742664,EBI-530034 PHF1  
  .positive regulation of histone H3-K27 methylation
.negative regulation of histone H3-K27 methylation
.negative regulation of gene expression, epigenetic
  + 5 more...
.methylated histone binding
.zinc ion binding
.sequence-specific DNA binding transcription factor activity
.site of double-strand break
.microtubule organizing center
.cytoplasm
  + 2 more...
2 EBI-742664,EBI-1043398 MPG  
  .depurination
.DNA dealkylation involved in DNA repair
.base-excision repair, AP site formation
  + 2 more...
.DNA-3-methylguanine glycosylase activity
.DNA-7-methyladenine glycosylase activity
.DNA-7-methylguanine glycosylase activity
  + 3 more...
.mitochondrial nucleoid
.nucleoplasm
3 EBI-742664,EBI-718700 CA8  
  .phosphatidylinositol-mediated signaling
.one-carbon metabolic process
.zinc ion binding
.carbonate dehydratase activity
.cytoplasm
4 EBI-742664,EBI-10173632 DDIT3  
  .negative regulation of determination of dorsal identity
.positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
.negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding
  + 32 more...
.protein heterodimerization activity
.transcription regulatory region DNA binding
.leucine zipper domain binding
  + 8 more...
.CHOP-ATF3 complex
.CHOP-ATF4 complex
.CHOP-C/EBP complex
  + 5 more...
5 EBI-742664,EBI-745859 CDKN2D  
  .negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
.negative regulation of protein serine/threonine kinase activity
.autophagic cell death
  + 13 more...
.protein kinase binding
.cyclin-dependent protein serine/threonine kinase inhibitor activity
.cytosol
.cytoplasm
.nucleus
6 EBI-742664,EBI-740486 NUDT18  
  .nucleobase-containing small molecule metabolic process
.GDP catabolic process
.dGDP catabolic process
  + 3 more...
.8-hydroxy-dADP phosphatase activity
.8-oxo-GDP phosphatase activity
.8-oxo-dGDP phosphatase activity
.magnesium ion binding
.cytosol
7 EBI-742664,EBI-10268630 SREK1IP1  
  .RNA splicing
.mRNA processing
.zinc ion binding
.nucleic acid binding
.N/A
8 EBI-742664,EBI-1760638 SNAPC3  
  .gene expression
.snRNA transcription
.transcription from RNA polymerase III promoter
  + 2 more...
.DNA binding .nucleolus
.nucleoplasm
.nucleus
9 EBI-742664,EBI-741158 WDYHV1  
  .cellular protein modification process .protein-N-terminal glutamine amidohydrolase activity .cytosol
.nucleus
10 EBI-742664,EBI-740364 NEK6  
  .regulation of cellular senescence
.spindle assembly
.protein autophosphorylation
  + 13 more...
.protein kinase binding
.kinesin binding
.ATP binding
  + 3 more...
.nuclear speck
.microtubule
.cytosol
  + 4 more...
11 EBI-742664,EBI-8787464 TBC1D22B  
  .N/A .GTPase activator activity .N/A
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
bone13
brain13
cervix20
ear124
embryonic tissue14
eye62
intestine21
kidney90
liver24
lung65
lymph22
mammary gland6
ovary29
pancreas23
parathyroid48
placenta10
prostate5
skin33
spleen18
stomach10
testis11
thyroid42
uterus17
Health State
TissuesTPM*
normal24
colorectal tumor8
gastrointestinal tumor16
glioma37
head and neck tumor14
kidney tumor14
leukemia10
liver tumor41
lymphoma13
primitive neuroectodermal tumor of the CNS15
prostate cancer9
retinoblastoma21
skin tumor39
soft tissue/muscle tissue tumor7
uterine tumor11
Developmental Stage
TissuesTPM*
adult22
embryoid body14
blastocyst32
fetus34
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue3.4
adrenal gland21
appendix2.2
cerebral cortex12.3
colon3.2
duodenum1.4
esophagus1.9
gallbladder10.5
heart muscle3.9
kidney55.1
liver14.8
lung7.7
lymph node6
ovary28
pancreas2.3
placenta6.2
prostate10
salivary gland1.7
skin2.7
small intestine3.1
spleen6.8
stomach2.3
testis3.1
thyroid gland19.9
urinary bladder9
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*612832, gene) 17-@beta-hydroxysteroid dehydrogenase xiv; HSD17B14OMIM


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