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> Protein (NX_Q9BQ24)
Protein (NX_Q9BQ24)
Protein
Gene SymbolZFYVE21 to neXtProt (NX_Q9BQ24)
DescriptionZinc finger FYVE domain-containing protein 21
Chromosome14
Location14q32.33 (104182067 ~ 104200005) to Ensembl
Sequene Features : Isoforms 2, Variants 22, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.N/A .metal ion binding .cytoplasmic membrane-bounded vesicle
.focal adhesion
.endosome
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 22 1
2014-09-19protein level
2 18 1
2014-05-27protein level
2 18 1
2014-02-25protein level
2 18 1
2013-12-09protein level
2 15 1
2013-11-01protein level
2 13 1
2013-09-12protein level
2 13 1
2013-08-17protein level
2 13 1
2013-07-15protein level
2 13 1
2013-06-11protein level
2 13 1
2013-02-12protein level
2 8 0
2012-12-20protein level
2 8 0
2012-10-30protein level
2 7 0
2012-10-07protein level
2 7 0
2012-08-24protein level
2 5 0
2012-07-28protein level
2 5 0
2012-06-08protein level
2 6 0
2012-05-07protein level
2 4 0
2012-04-10protein level
2 4 0
2012-01-13protein level
2 4 0
2011-12-20protein level
2 4 0
2011-11-11protein level
2 4 0
2011-08-23protein level
2 4 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9BQ24-1
1 8 0 26488.1304
NX_Q9BQ24-2
3 8 0 28458.0742
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-2849569,EBI-1047263 KRT38  
  .N/A .structural molecule activity .extracellular exosome
.intermediate filament
2 EBI-2849569,EBI-719493 TRIM27  
  .negative regulation of viral release from host cell
.negative regulation of interleukin-2 secretion
.negative regulation of calcium ion import
  + 17 more...
.metal ion binding
.ligase activity
.zinc ion binding
  + 4 more...
.nuclear membrane
.PML body
.membrane
  + 6 more...
3 EBI-2849569,EBI-3958099 KRTAP5-9  
  .epidermis development .N/A .keratin filament
4 EBI-2849569,EBI-10172150 KRTAP10-5  
  .N/A .identical protein binding .keratin filament
5 EBI-2849569,EBI-10171774 KRTAP10-8  
  .N/A .N/A .keratin filament
6 EBI-2849569,EBI-359224 TRAF1  
  .regulation of extrinsic apoptotic signaling pathway
.positive regulation of NF-kappaB transcription factor activity
.signal transduction
  + 2 more...
.thioesterase binding
.ubiquitin protein ligase binding
.zinc ion binding
.tumor necrosis factor receptor binding
.cytoplasm
7 EBI-2849569,EBI-714543 ARL6IP1  
  .cotranslational protein targeting to membrane .N/A .integral component of membrane
.membrane
.cytosol
.Sec61 translocon complex
8 EBI-2849569,EBI-948001 KRT31  
  .epidermis development .structural constituent of cytoskeleton .extracellular exosome
.intermediate filament
.extracellular space
9 EBI-2849569,EBI-742948 MTUS2  
  .N/A .protein homodimerization activity
.microtubule binding
.microtubule
.cytoplasm
.nucleus
10 EBI-2849569,EBI-1105124 PDE4DIP  
  .cellular protein complex assembly .enzyme binding .myofibril
.centrosome
.Golgi apparatus
  + 2 more...
11 EBI-2849569,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
12 EBI-2849569,EBI-741181 AGTRAP  
  .regulation of blood pressure
.response to hypoxia
.angiotensin type II receptor activity .intracellular membrane-bounded organelle
.cytoplasmic vesicle membrane
.integral component of membrane
  + 6 more...
13 EBI-2849569,EBI-945833 NOTCH2NL  
  .cell differentiation
.multicellular organismal development
.Notch signaling pathway
.calcium ion binding .cytoplasm
.extracellular region
14 EBI-2849569,EBI-747107 SIAH1  
  .positive regulation of intrinsic apoptotic signaling pathway
.neuron apoptotic process
.proteasome-mediated ubiquitin-dependent protein catabolic process
  + 11 more...
.ubiquitin protein ligase activity
.identical protein binding
.ligase activity
  + 3 more...
.beta-catenin destruction complex
.plasma membrane
.cytosol
  + 3 more...
15 EBI-2849569,EBI-750345 REEP6  
  .regulation of intracellular transport .N/A .apical part of cell
.rod spherule
.integral component of membrane
  + 2 more...
16 EBI-2849569,EBI-715945 RTN4  
  .regulation of branching morphogenesis of a nerve
.endoplasmic reticulum tubular network organization
.cardiac epithelial to mesenchymal transition
  + 11 more...
.poly(A) RNA binding .extracellular exosome
.neuronal cell body
.cell projection
  + 5 more...
17 EBI-2849569,EBI-712367 RABAC1  
  .N/A .identical protein binding .cell junction
.integral component of membrane
.membrane
  + 3 more...
18 EBI-2849569,EBI-10172526 MID2  
  .negative regulation of viral release from host cell
.positive regulation of NF-kappaB transcription factor activity
.positive regulation of sequence-specific DNA binding transcription factor activity
  + 6 more...
.phosphoprotein binding
.protein heterodimerization activity
.protein homodimerization activity
  + 3 more...
.extracellular exosome
.microtubule
.cytoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
adrenal gland30
ascites25
bladder66
bone27
bone marrow61
brain53
cervix20
connective tissue6
ear62
embryonic tissue37
eye33
heart33
intestine21
kidney75
liver4
lung23
lymph45
mouth15
nerve193
ovary39
pancreas28
placenta35
prostate15
salivary gland197
skin80
spleen37
stomach20
testis57
thymus12
thyroid21
trachea19
umbilical cord72
uterus38
Health State
TissuesTPM*
normal39
bladder carcinoma113
cervical tumor28
chondrosarcoma36
colorectal tumor26
gastrointestinal tumor8
germ cell tumor30
glioma93
head and neck tumor37
kidney tumor72
leukemia10
lung tumor19
lymphoma27
non-neoplasia41
ovarian tumor26
pancreatic tumor38
primitive neuroectodermal tumor of the CNS15
retinoblastoma21
skin tumor47
soft tissue/muscle tissue tumor23
uterine tumor33
Developmental Stage
TissuesTPM*
adult32
embryoid body42
neonate32
fetus28
juvenile53
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue48.5
adrenal gland28.4
appendix16.4
bone marrow11.4
cerebral cortex48.7
colon35.1
duodenum22.4
esophagus50.9
gallbladder34.9
heart muscle43.9
kidney36.2
liver17.6
lung33.7
lymph node19.1
ovary53.6
pancreas11.7
placenta31.2
prostate51.2
salivary gland49.5
skin58.2
small intestine21.8
spleen32.1
stomach28.6
testis41.9
thyroid gland58.5
urinary bladder41.1
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*613504, gene) Zinc finger fyve domain-containing protein 21; ZFYVE21OMIM


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