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> Protein (NX_Q9BQS8)
Protein (NX_Q9BQS8)
Protein
Gene SymbolFYCO1 to neXtProt (NX_Q9BQS8)
DescriptionFYVE and coiled-coil domain-containing protein 1
Chromosome3
Location3p21.31 (45959396 ~ 46037316) to Ensembl
Sequene Features : Isoforms 4, Variants 209, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.plus-end-directed vesicle transport along microtubule .metal ion binding .cytoplasmic vesicle
.integral component of membrane
.membrane
  + 3 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
4 209 5
2014-09-19protein level
4 174 5
2014-05-27protein level
4 174 6
2014-02-25protein level
3 174 6
2013-12-09protein level
3 127 6
2013-11-01protein level
3 124 6
2013-09-12protein level
3 124 6
2013-08-17protein level
3 124 6
2013-07-15protein level
3 94 5
2013-06-11protein level
3 94 5
2013-02-12protein level
3 63 6
2012-12-20protein level
3 64 6
2012-10-30protein level
3 79 6
2012-10-07protein level
3 79 4
2012-08-24protein level
3 65 4
2012-07-28protein level
3 65 4
2012-06-08protein level
3 17 4
2012-05-07protein level
3 17 4
2012-04-10protein level
3 17 4
2012-01-13protein level
3 17 4
2011-12-20protein level
3 17 4
2011-11-11protein level
3 17 3
2011-08-23protein level
3 16 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9BQS8-1
1 71 0 166878.8966
NX_Q9BQS8-2
1 19 0 43454.6426
NX_Q9BQS8-3
1 19 0 43399.6006
NX_Q9BQS8-4
3 71 0 168782.8155
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-2869338,EBI-710124 KDM1A  
  .positive regulation of stem cell proliferation
.positive regulation of neural precursor cell proliferation
.negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
  + 27 more...
.androgen receptor binding
.flavin adenine dinucleotide binding
.transcription regulatory region DNA binding
  + 13 more...
.transcription factor complex
.nucleoplasm
.nucleus
.nuclear chromatin
2 EBI-2869338,EBI-712001 GABARAP  
  .membrane fusion
.nucleophagy
.extrinsic apoptotic signaling pathway via death domain receptors
  + 5 more...
.GABA receptor binding
.beta-tubulin binding
.microtubule binding
.perinuclear region of cytoplasm
.cell body
.cytoplasmic vesicle
  + 13 more...
3 EBI-2869338,EBI-720116 GABARAPL2  
  .negative regulation of proteasomal protein catabolic process
.membrane fusion
.nucleophagy
  + 7 more...
.ATPase binding
.GABA receptor binding
.beta-tubulin binding
  + 2 more...
.cytoplasmic vesicle
.extrinsic component of membrane
.cytosol
  + 7 more...
4 EBI-2869338,EBI-912440 PRMT6  
  .negative regulation of transcription, DNA-templated
.histone H4-R3 methylation
.histone H3-R2 methylation
  + 6 more...
.histone methyltransferase activity (H2A-R3 specific)
.histone methyltransferase activity (H3-R2 specific)
.histone methyltransferase activity (H4-R3 specific)
  + 5 more...
.cytosol
.nucleoplasm
.nucleus
5 EBI-2869338,EBI-2603996 MAP1LC3C  
  .membrane fusion
.nucleophagy
.cellular response to nitrogen starvation
  + 2 more...
.microtubule binding .cytoplasmic vesicle
.organelle membrane
.extrinsic component of membrane
  + 6 more...
6 EBI-2869338,EBI-373144 MAP1LC3B  
  .regulation of mitochondrion degradation
.membrane fusion
.nucleophagy
  + 3 more...
.microtubule binding .cytoplasmic vesicle
.organelle membrane
.extrinsic component of membrane
  + 9 more...
7 EBI-2869338,EBI-746969 GABARAPL1  
  .membrane fusion
.nucleophagy
.mitochondrion degradation
.autophagic vacuole assembly
.GABA receptor binding
.beta-tubulin binding
.Tat protein binding
.microtubule binding
.cell body
.dendrite cytoplasm
.dendrite membrane
  + 10 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
bladder33
blood16
bone27
bone marrow20
brain16
cervix103
connective tissue33
embryonic tissue18
eye52
heart55
intestine8
kidney52
larynx42
liver19
lung47
lymph node22
mammary gland52
mouth45
muscle75
nerve64
ovary78
pancreas9
parathyroid97
placenta17
prostate52
skin90
stomach10
thymus25
thyroid85
trachea38
uterus56
vascular38
Health State
TissuesTPM*
normal32
bladder carcinoma56
breast (mammary gland) tumor42
cervical tumor57
chondrosarcoma84
gastrointestinal tumor8
germ cell tumor11
glioma46
head and neck tumor29
kidney tumor58
leukemia10
liver tumor20
lung tumor19
non-neoplasia20
ovarian tumor91
prostate cancer38
retinoblastoma21
skin tumor63
soft tissue/muscle tissue tumor23
uterine tumor44
Developmental Stage
TissuesTPM*
adult45
embryoid body14
blastocyst48
fetus32
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue13.4
adrenal gland8.4
appendix10.2
bone marrow3.7
cerebral cortex2.6
colon11.8
duodenum7.4
esophagus21.1
gallbladder20.2
heart muscle51.3
kidney10.1
liver4.4
lung13.3
lymph node8.3
ovary22.8
pancreas5.3
placenta6.6
prostate18.5
salivary gland9.1
skin14.5
small intestine8.3
spleen9.8
stomach11.4
testis4.1
thyroid gland16.9
urinary bladder19.6
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*607182, gene) Fyve and coiled-coil domain containing 1; FYCO1OMIM
2(#610019, phenotype) Cataract, autosomal recessive congenital 2; CATC2OMIM


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