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> Protein (NX_Q9BRG1)
Protein (NX_Q9BRG1)
Protein
Gene SymbolVPS25 to neXtProt (NX_Q9BRG1)
DescriptionVacuolar protein-sorting-associated protein 25
Chromosome17
Location17q21.31 (40925454 ~ 40931617) to Ensembl
Sequene Features : Isoforms 1, Variants 15, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.membrane organization
.protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
.endosomal transport
  + 2 more...
.protein N-terminus binding
.protein homodimerization activity
.structural molecule activity
.extracellular exosome
.endosome membrane
.cytosol
  + 6 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 15 1
2014-09-19protein level
1 14 1
2014-05-27protein level
1 14 1
2014-02-25protein level
1 14 1
2013-12-09protein level
1 9 1
2013-11-01protein level
1 7 1
2013-09-12protein level
1 7 1
2013-08-17protein level
1 7 1
2013-07-15protein level
1 6 0
2013-06-11protein level
1 6 0
2013-02-12protein level
1 3 0
2012-12-20protein level
1 3 0
2012-10-30protein level
1 3 0
2012-10-07protein level
1 3 0
2012-08-24protein level
1 3 0
2012-07-28protein level
1 3 0
2012-06-08protein level
1 5 0
2012-05-07protein level
1 4 0
2012-04-10protein level
1 4 0
2012-01-13protein level
1 5 0
2011-12-20protein level
1 5 0
2011-11-11protein level
1 5 0
2011-08-23protein level
1 5 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9BRG1-1
11 0 0 20734.4511
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-741945,EBI-719493 TRIM27  
  .negative regulation of viral release from host cell
.negative regulation of interleukin-2 secretion
.negative regulation of calcium ion import
  + 17 more...
.metal ion binding
.ligase activity
.zinc ion binding
  + 4 more...
.nuclear membrane
.PML body
.membrane
  + 6 more...
2 EBI-741945,EBI-307352 REL  
  .negative regulation of neuron death
.positive regulation of transcription from RNA polymerase II promoter
.innate immune response
  + 10 more...
.sequence-specific DNA binding transcription factor activity
.chromatin binding
.RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.RNA polymerase II distal enhancer sequence-specific DNA binding
.I-kappaB/NF-kappaB complex
.cytosol
.transcription factor complex
  + 2 more...
3 EBI-741945,EBI-724373 BEND5  
  .N/A .N/A .Golgi apparatus
4 EBI-741945,EBI-2872414 CRLF3  
  .positive regulation of cell cycle arrest
.positive regulation of JAK-STAT cascade
.positive regulation of transcription from RNA polymerase II promoter
  + 3 more...
.N/A .plasma membrane
.cytoplasm
5 EBI-741945,EBI-747719 SNF8  
  .regulation of viral budding via host ESCRT complex
.positive regulation of exosomal secretion
.regulation of protein complex stability
  + 11 more...
.protein N-terminus binding
.protein homodimerization activity
.channel regulator activity
  + 2 more...
.extracellular exosome
.recycling endosome
.perinuclear region of cytoplasm
  + 10 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland91
ascites75
bladder66
blood57
bone153
brain43
cervix103
connective tissue13
embryonic tissue122
esophagus49
eye95
heart67
intestine56
kidney71
larynx42
liver92
lung77
lymph90
lymph node44
mammary gland26
muscle37
ovary88
pancreas70
parathyroid145
pharynx171
placenta52
prostate84
salivary gland296
skin99
stomach73
testis29
thymus12
thyroid42
uterus56
vascular38
Health State
TissuesTPM*
normal59
bladder carcinoma113
breast (mammary gland) tumor32
cervical tumor86
chondrosarcoma144
colorectal tumor53
esophageal tumor57
gastrointestinal tumor59
germ cell tumor22
glioma111
head and neck tumor74
kidney tumor29
leukemia21
liver tumor145
lung tumor97
lymphoma96
non-neoplasia51
ovarian tumor105
pancreatic tumor57
primitive neuroectodermal tumor of the CNS86
prostate cancer105
retinoblastoma64
skin tumor95
soft tissue/muscle tissue tumor31
uterine tumor44
Developmental Stage
TissuesTPM*
adult59
embryoid body214
blastocyst97
fetus62
infant42
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue27.7
adrenal gland24.1
appendix32
bone marrow32.6
cerebral cortex20.6
colon54.5
duodenum46.1
esophagus61.3
gallbladder36.4
heart muscle28
kidney41
liver27.8
lung30.2
lymph node36.6
ovary32
pancreas19.1
placenta41.8
prostate33.9
salivary gland24.5
skin31.6
small intestine39.4
spleen23.7
stomach37.5
testis23.5
thyroid gland40.2
urinary bladder40.4
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*610907, gene) Vacuolar protein sorting 25, s. cerevisiae, homolog of; VPS25OMIM


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