Home| Contact Us

HOME SEARCH STATISTICS
> Protein (NX_Q9BRK4)
Protein (NX_Q9BRK4)
Protein
Gene SymbolLZTS2 to neXtProt (NX_Q9BRK4)
DescriptionLeucine zipper putative tumor suppressor 2
Chromosome10
Location10q24.31 (102756375 ~ 102767593) to Ensembl
Sequene Features : Isoforms 1, Variants 92, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of protein localization to nucleus
.negative regulation of canonical Wnt signaling pathway
.spindle midzone assembly
  + 7 more...
.N/A .midbody
.microtubule
.centrosome
.cytoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 92 2
2014-09-19protein level
1 77 2
2014-05-27protein level
1 77 2
2014-02-25protein level
1 75 2
2013-12-09protein level
1 52 2
2013-11-01protein level
1 52 1
2013-09-12protein level
1 52 1
2013-08-17protein level
1 52 1
2013-07-15protein level
1 35 1
2013-06-11protein level
1 35 1
2013-02-12protein level
1 21 1
2012-12-20protein level
1 22 1
2012-10-30protein level
1 24 1
2012-10-07protein level
1 24 1
2012-08-24protein level
1 21 1
2012-07-28protein level
1 21 1
2012-06-08protein level
1 19 1
2012-05-07protein level
1 19 1
2012-04-10protein level
1 19 1
2012-01-13protein level
1 12 1
2011-12-20protein level
1 12 1
2011-11-11protein level
1 12 1
2011-08-23protein level
1 12 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9BRK4-1
29 0 1 72714.6864
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-741037,EBI-308663 ARHGAP32  
  .regulation of small GTPase mediated signal transduction
.small GTPase mediated signal transduction
.phosphatidylinositol binding
.GTPase activator activity
.postsynaptic membrane
.dendritic spine
.cell junction
  + 7 more...
2 EBI-741037,EBI-1055079 POLR1C  
  .negative regulation of gene expression, epigenetic
.innate immune response
.regulation of gene expression, epigenetic
  + 9 more...
.DNA-directed RNA polymerase activity
.DNA binding
.cytosol
.DNA-directed RNA polymerase I complex
.DNA-directed RNA polymerase III complex
.nucleoplasm
3 EBI-741037,EBI-353818 EIF3D  
  .cellular protein metabolic process
.gene expression
.regulation of translational initiation
  + 4 more...
.poly(A) RNA binding
.translation initiation factor activity
.eukaryotic translation initiation factor 3 complex, eIF3m
.eukaryotic 48S preinitiation complex
.eukaryotic 43S preinitiation complex
  + 3 more...
4 EBI-741037,EBI-751857 MAGEB4  
  .N/A .N/A .N/A
5 EBI-741037,EBI-349968 SUV39H1  
  .cellular response to hypoxia
.rhythmic process
.negative regulation of transcription, DNA-templated
  + 15 more...
.protein N-terminus binding
.histone methyltransferase activity (H3-K9 specific)
.histone methyltransferase activity
  + 5 more...
.rDNA heterochromatin
.chromatin silencing complex
.nucleoplasm
  + 5 more...
6 EBI-741037,EBI-713635 NCK2  
  .negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
.ephrin receptor signaling pathway
.vascular endothelial growth factor receptor signaling pathway
  + 16 more...
.receptor signaling complex scaffold activity
.cytoskeletal adaptor activity
.SH3/SH2 adaptor activity
.vesicle membrane
.cytosol
.endoplasmic reticulum
.cytoplasm
7 EBI-741037,EBI-1053424 PRKAB2  
  .membrane organization
.regulation of protein kinase activity
.small molecule metabolic process
  + 13 more...
.identical protein binding .AMP-activated protein kinase complex
.cytosol
.nucleoplasm
8 EBI-741037,EBI-398610 EIF4E2  
  .cytokine-mediated signaling pathway
.negative regulation of translation
.in utero embryonic development
.poly(A) RNA binding
.ubiquitin protein ligase binding
.translation factor activity, RNA binding
  + 2 more...
.mRNA cap binding complex
.cytosol
9 EBI-741037,EBI-713867 PQBP1  
  .regulation of dendrite morphogenesis
.regulation of RNA splicing
.neuron projection development
  + 3 more...
.ribonucleoprotein complex binding
.transcription coactivator activity
.DNA binding
.neuronal ribonucleoprotein granule
.nuclear speck
.cytoplasmic stress granule
  + 3 more...
10 EBI-741037,EBI-744771 FKBP6  
  .chaperone-mediated protein folding
.DNA methylation involved in gamete generation
.piRNA metabolic process
  + 6 more...
.Hsp90 protein binding
.FK506 binding
.peptidyl-prolyl cis-trans isomerase activity
.cytosol
.endoplasmic reticulum membrane
.cytoplasm
.synaptonemal complex
11 EBI-741037,EBI-743272 USP2  
  .regulation of proteasomal protein catabolic process
.protein stabilization
.positive regulation of skeletal muscle tissue development
  + 11 more...
.metal ion binding
.ubiquitin protein ligase binding
.cyclin binding
  + 2 more...
.perinuclear region of cytoplasm
.cell cortex
.centrosome
  + 2 more...
12 EBI-741037,EBI-1055693 RAD51D  
  .strand invasion
.reciprocal meiotic recombination
.DNA repair
  + 2 more...
.gamma-tubulin binding
.DNA-dependent ATPase activity
.ATP binding
  + 2 more...
.Rad51B-Rad51C-Rad51D-XRCC2 complex
.centrosome
.cytoplasm
  + 3 more...
13 EBI-741037,EBI-739806 CCNK  
  .positive regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues
.negative regulation of cell cycle arrest
.cell division
  + 8 more...
.protein kinase binding
.RNA polymerase II carboxy-terminal domain kinase activity
.cyclin-dependent protein serine/threonine kinase activity
.nucleus
.cyclin K-CDK13 complex
.cyclin K-CDK12 complex
14 EBI-741037,EBI-2880203 NEBL  
  .cardiac muscle thin filament assembly .actin filament binding
.filamin binding
.structural constituent of muscle
  + 2 more...
.extracellular exosome
.I band
.Z disc
.stress fiber
15 EBI-741037,EBI-750559 SLU7  
  .cellular response to heat
.intracellular protein transport
.mRNA splicing, via spliceosome
  + 3 more...
.pre-mRNA 3'-splice site binding
.zinc ion binding
.second spliceosomal transesterification activity
.catalytic step 2 spliceosome
.intracellular membrane-bounded organelle
.small nuclear ribonucleoprotein complex
  + 6 more...
16 EBI-741037,EBI-10192902 FAM107A  
  .regulation of cell growth .N/A .neuron projection
.nucleus
17 EBI-741037,EBI-1757866 MOS  
  .negative regulation of metaphase/anaphase transition of meiotic cell cycle
.establishment of meiotic spindle orientation
.protein autophosphorylation
  + 6 more...
.ATP binding
.MAP kinase kinase kinase activity
.protein serine/threonine kinase activity
.cytoplasm
18 EBI-741037,EBI-1348 LCK  
  .positive regulation of intrinsic apoptotic signaling pathway
.cellular response to peptide hormone stimulus
.positive regulation of uterine smooth muscle contraction
  + 35 more...
.ATPase binding
.phosphatidylinositol 3-kinase binding
.identical protein binding
  + 12 more...
.extracellular exosome
.membrane raft
.extrinsic component of cytoplasmic side of plasma membrane
  + 6 more...
19 EBI-741037,EBI-352528 HSPD1  
  .protein maturation
.chaperone-mediated protein complex assembly
.positive regulation of T cell activation
  + 21 more...
.chaperone binding
.unfolded protein binding
.poly(A) RNA binding
  + 8 more...
.extracellular exosome
.lipopolysaccharide receptor complex
.protein complex
  + 13 more...
20 EBI-741037,EBI-356254 SLC25A6  
  .regulation of insulin secretion
.active induction of host immune response by virus
.small molecule metabolic process
  + 9 more...
.ATP:ADP antiporter activity .integral component of membrane
.mitochondrial inner membrane presequence translocase complex
.mitochondrial inner membrane
  + 2 more...
21 EBI-741037,EBI-10177272 ZNF250  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.nucleus
22 EBI-741037,EBI-717634 ZNF20  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
23 EBI-741037,EBI-739899 ZBTB25  
  .gene expression
.transcription from RNA polymerase II promoter
.regulation of transcription from RNA polymerase II promoter
.metal ion binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.RNA polymerase II regulatory region sequence-specific DNA binding
.cytoplasm
.nucleoplasm
24 EBI-741037,EBI-395261 CCNC  
  .positive regulation of transcription from RNA polymerase II promoter
.gene expression
.Notch signaling pathway
  + 4 more...
.N/A .mediator complex
.nucleoplasm
25 EBI-741037,EBI-359352 PSMA1  
  .positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
  + 23 more...
.threonine-type endopeptidase activity
.endopeptidase activity
.RNA binding
.extracellular exosome
.proteasome core complex, alpha-subunit complex
.polysome
  + 7 more...
26 EBI-741037,EBI-739696 LMO2  
  .cellular response to thyroid hormone stimulus
.positive regulation of transcription from RNA polymerase II promoter
.negative regulation of erythrocyte differentiation
  + 3 more...
.E-box binding
.cofactor binding
.bHLH transcription factor binding
  + 7 more...
.transcription factor complex
.nucleus
27 EBI-741037,EBI-8639312 LMO1  
  .positive regulation of transcription from RNA polymerase II promoter
.negative regulation of transcription from RNA polymerase II promoter
.zinc ion binding .nucleus
28 EBI-741037,EBI-347462 QARS  
  .gene expression
.brain development
.glutaminyl-tRNA aminoacylation
.tRNA aminoacylation for protein translation
.ATP binding
.glutamine-tRNA ligase activity
.cytosol
.mitochondrial matrix
.cytoplasm
29 EBI-741037,EBI-3905829 CCNG1  
  .cell division
.negative regulation of apoptotic process
.cell growth
  + 6 more...
.N/A .perinuclear region of cytoplasm
.neuronal cell body
.dendrite
.nucleus
30 EBI-741037,EBI-464729 NCBP2  
  .positive regulation of viral transcription
.positive regulation of RNA export from nucleus
.mRNA cis splicing, via spliceosome
  + 17 more...
.poly(A) RNA binding
.RNA 7-methylguanosine cap binding
.RNA cap binding
.nucleotide binding
.nuclear cap binding complex
.mRNA cap binding complex
.cytosol
  + 3 more...
31 EBI-741037,EBI-744104 GEM  
  .metaphase plate congression
.chromosome organization
.metabolic process
  + 5 more...
.GDP binding
.GTP binding
.GTPase activity
.magnesium ion binding
.mitotic spindle
.spindle midzone
.midbody
  + 2 more...
32 EBI-741037,EBI-6657662 FGF12  
  .negative regulation of cation channel activity
.regulation of sodium ion transmembrane transporter activity
.regulation of sodium ion transmembrane transport
  + 12 more...
.ion channel binding
.sodium channel regulator activity
.heparin binding
.growth factor activity
.nucleus
.extracellular space
33 EBI-741037,EBI-401755 GRB2  
  .positive regulation of reactive oxygen species metabolic process
.cellular response to ionizing radiation
.branching involved in labyrinthine layer morphogenesis
  + 25 more...
.ephrin receptor binding
.poly(A) RNA binding
.insulin receptor substrate binding
  + 6 more...
.Grb2-EGFR complex
.extracellular exosome
.vesicle membrane
  + 10 more...
34 EBI-741037,EBI-413628 RAC1  
  .positive regulation of substrate adhesion-dependent cell spreading
.apoptotic signaling pathway
.ruffle assembly
  + 63 more...
.Rho GDP-dissociation inhibitor binding
.thioesterase binding
.enzyme binding
  + 2 more...
.extracellular exosome
.melanosome
.cytoplasmic ribonucleoprotein granule
  + 12 more...
35 EBI-741037,EBI-746539 TXNL4A  
  .cell division
.gene expression
.RNA splicing
  + 4 more...
.N/A .U4/U6 x U5 tri-snRNP complex
.U5 snRNP
.spliceosomal complex
.nucleoplasm
36 EBI-741037,EBI-10223946 WT1-AS  
  .N/A .N/A .N/A
37 EBI-741037,EBI-10224192 RUNX1T1  
  .negative regulation of transcription, DNA-templated
.transcription, DNA-templated
.generation of precursor metabolites and energy
.metal ion binding
.identical protein binding
.transcription corepressor activity
  + 2 more...
.nuclear matrix
.mitochondrion
.cytoplasm
.nucleoplasm
38 EBI-741037,EBI-746238 CDK18  
  .N/A .ATP binding
.cyclin-dependent protein serine/threonine kinase activity
.N/A
39 EBI-741037,EBI-2339219 EHHADH  
  .fatty acid beta-oxidation
.internal protein amino acid acetylation
.coenzyme binding
.enzyme binding
.receptor binding
  + 3 more...
.cytosol
.peroxisome
.mitochondrion
40 EBI-741037,EBI-714236 MTA1  
  .negative regulation of nucleic acid-templated transcription
.positive regulation of protein autoubiquitination
.regulation of inflammatory response
  + 11 more...
.zinc ion binding
.transcription corepressor activity
.transcription coactivator activity
  + 5 more...
.intracellular membrane-bounded organelle
.NuRD complex
.microtubule
  + 4 more...
41 EBI-741037,EBI-632715 SNW1  
  .cellular response to retinoic acid
.positive regulation of vitamin D receptor signaling pathway
.regulation of vitamin D receptor signaling pathway
  + 19 more...
.SMAD binding
.poly(A) RNA binding
.retinoic acid receptor binding
  + 5 more...
.catalytic step 2 spliceosome
.nuclear matrix
.spliceosomal complex
  + 3 more...
42 EBI-741037,EBI-1053596 DYRK1A  
  .positive regulation of protein deacetylation
.protein autophosphorylation
.negative regulation of DNA damage response, signal transduction by p53 class mediator
  + 8 more...
.tau protein binding
.protein self-association
.ATP binding
  + 5 more...
.ribonucleoprotein complex
.nuclear speck
.nucleoplasm
.nucleus
43 EBI-741037,EBI-366017 RIN1  
  .negative regulation of synaptic plasticity
.associative learning
.memory
  + 2 more...
.GTPase activator activity .neuronal cell body
.dendrite
.plasma membrane
  + 2 more...
44 EBI-741037,EBI-358049 BYSL  
  .cell proliferation
.female pregnancy
.cell adhesion
  + 2 more...
.poly(A) RNA binding .apical part of cell
.intracellular membrane-bounded organelle
.membrane
  + 3 more...
45 EBI-741037,EBI-702370 TRIM29  
  .negative regulation of protein localization to nucleus
.transcription from RNA polymerase II promoter
.negative regulation of transcription from RNA polymerase II promoter
.zinc ion binding
.sequence-specific DNA binding transcription factor activity
.intermediate filament cytoskeleton
.cytoplasm
.nucleoplasm
46 EBI-741037,EBI-2515248 FRG1  
  .muscle organ development
.rRNA processing
.mRNA splicing, via spliceosome
.poly(A) RNA binding .catalytic step 2 spliceosome
.Z disc
.Cajal body
.nucleolus
47 EBI-741037,EBI-742828 LASP1  
  .positive regulation of signal transduction
.ion transport
.ion transmembrane transporter activity
.zinc ion binding
.SH3/SH2 adaptor activity
.extracellular exosome
.cortical actin cytoskeleton
.focal adhesion
48 EBI-741037,EBI-10217913 RTP5  
  .N/A .N/A .integral component of membrane
49 EBI-741037,EBI-399257 MORF4L2  
  .positive regulation of striated muscle cell differentiation
.positive regulation of transcription from RNA polymerase II promoter
.regulation of growth
  + 4 more...
.N/A .nucleolus
.nucleoplasm
50 EBI-741037,EBI-710310 TCEA2  
  .positive regulation of transcription from RNA polymerase II promoter
.regulation of DNA-templated transcription, elongation
.DNA-templated transcription, elongation
.zinc ion binding
.DNA binding
.transcription elongation factor complex
.centrosome
.nucleoplasm
51 EBI-741037,EBI-1055994 USF2  
  .lipid homeostasis
.positive regulation of transcription from RNA polymerase II promoter
.late viral transcription
  + 4 more...
.protein heterodimerization activity
.sequence-specific DNA binding
.bHLH transcription factor binding
  + 5 more...
.nucleoplasm
.nucleus
52 EBI-741037,EBI-719941 FAM161A  
  .response to stimulus
.cilium assembly
.visual perception
.N/A .ciliary basal body
.photoreceptor connecting cilium
.centrosome
.cytoplasm
53 EBI-741037,EBI-10241513 PLEKHN1  
  .N/A .N/A .plasma membrane
54 EBI-741037,EBI-10247271 FAM74A6  
  .N/A .N/A .N/A
55 EBI-741037,EBI-6447954 TTC23  
  .N/A .N/A .N/A
56 EBI-741037,EBI-949239 KAZN  
  .keratinization .N/A .desmosome
.cytoskeleton
.cytoplasm
  + 2 more...
57 EBI-741037,EBI-2557469 PPP1R18  
  .N/A .N/A .cytoskeleton
.cytoplasm
58 EBI-741037,EBI-9675802 MORN3  
  .N/A .N/A .nucleus
59 EBI-741037,EBI-10257016 ZNF572  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
60 EBI-741037,EBI-3916986 SPATA24  
  .cell differentiation
.spermatogenesis
.multicellular organismal development
  + 2 more...
.DNA binding .cytoplasm
.nucleolus
.nucleoplasm
.nucleus
61 EBI-741037,EBI-3919850 CDKL3  
  .dendrite extension
.positive regulation of dendrite morphogenesis
.negative regulation of axon extension
.cellular protein modification process
.ATP binding
.cyclin-dependent protein serine/threonine kinase activity
.protein kinase activity
.cytoplasm
.nucleus
62 EBI-741037,EBI-2876787 SUPV3L1  
  .mitochondrial RNA surveillance
.chromatin maintenance
.mitochondrion morphogenesis
  + 10 more...
.poly(A) RNA binding
.protein homodimerization activity
.3'-5' RNA helicase activity
  + 7 more...
.mitochondrial degradosome
.mitochondrial nucleoid
.mitochondrial matrix
  + 2 more...
63 EBI-741037,EBI-749051 C6orf165  
  .N/A .N/A .N/A
64 EBI-741037,EBI-1104570 CEP57L1  
  .microtubule anchoring .N/A .microtubule
.microtubule organizing center
.cytoplasm
65 EBI-741037,EBI-5655540 CLIP4  
  .N/A .N/A .N/A
66 EBI-741037,EBI-3439227 ZGPAT  
  .negative regulation of transcription, DNA-templated
.negative regulation of epidermal growth factor-activated receptor activity
.negative regulation of transcription from RNA polymerase II promoter
.metal ion binding
.sequence-specific DNA binding
.sequence-specific DNA binding transcription factor activity
  + 2 more...
.nucleus
67 EBI-741037,EBI-1166928 ATPAF2  
  .proton-transporting ATP synthase complex assembly .N/A .nuclear speck
.mitochondrion
68 EBI-741037,EBI-10268010 MAB21L3  
  .N/A .N/A .N/A
69 EBI-741037,EBI-9380649 SNX31  
  .protein transport .phosphatidylinositol binding .protein complex
70 EBI-741037,EBI-741032 CNNM3  
  .ion transport .N/A .integral component of membrane
.membrane
.plasma membrane
71 EBI-741037,EBI-745707 GMCL1P1  
  .cell differentiation
.protein ubiquitination
.spermatogenesis
.multicellular organismal development
.N/A .nuclear matrix
72 EBI-741037,EBI-740727 ZNF417  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
73 EBI-741037,EBI-742750 BAHD1  
  .negative regulation of transcription, DNA-templated
.heterochromatin assembly
.transcription, DNA-templated
.chromatin silencing
.chromatin binding
.transcription regulatory region sequence-specific DNA binding
.chromatin silencing complex
.nucleoplasm
.chromatin
74 EBI-741037,EBI-347472 HM13  
  .membrane protein proteolysis .protein homodimerization activity
.aspartic endopeptidase activity, intramembrane cleaving
.ubiquitin protein ligase binding
.peptidase activity
.integral component of lumenal side of endoplasmic reticulum membrane
.integral component of cytoplasmic side of endoplasmic reticulum membrane
.membrane
  + 4 more...
75 EBI-741037,EBI-10244131 FBF1  
  .establishment of epithelial cell polarity
.apical junction assembly
.cilium assembly
.organelle organization
.N/A .ciliary transition fiber
.cell junction
.cytosol
  + 3 more...
76 EBI-741037,EBI-8637627 AEN  
  .nucleic acid phosphodiester bond hydrolysis
.intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
.response to ionizing radiation
.exonuclease activity
.nucleic acid binding
.nuclear membrane
.nucleolus
.nucleoplasm
.nucleus
77 EBI-741037,EBI-749432 DYRK2  
  .negative regulation of NFAT protein import into nucleus
.positive regulation of glycogen biosynthetic process
.intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
  + 4 more...
.ubiquitin binding
.manganese ion binding
.ATP binding
  + 4 more...
.ribonucleoprotein complex
.cytoplasm
.nucleoplasm
  + 2 more...
78 EBI-741037,EBI-399080 KAT5  
  .positive regulation of protein acetylation
.cellular response to estradiol stimulus
.positive regulation of transcription from RNA polymerase II promoter
  + 14 more...
.repressing transcription factor binding
.androgen receptor binding
.metal ion binding
  + 2 more...
.perinuclear region of cytoplasm
.NuA4 histone acetyltransferase complex
.Piccolo NuA4 histone acetyltransferase complex
  + 6 more...
79 EBI-741037,EBI-746252 GCC1  
  .protein targeting to Golgi .N/A .plasma membrane
.Golgi apparatus
.cytoplasm
.Golgi membrane
80 EBI-741037,EBI-746259 OTUB2  
  .protein K48-linked deubiquitination
.protein K63-linked deubiquitination
.protein K11-linked deubiquitination
.protein deubiquitination
.ubiquitin-specific protease activity .nucleus
81 EBI-741037,EBI-746595 ZMYND19  
  .N/A .metal ion binding .synapse
.plasma membrane
.cytoplasm
82 EBI-741037,EBI-740086 DCUN1D1  
  .N/A .N/A .nucleus
.ubiquitin ligase complex
83 EBI-741037,EBI-748884 LIN37  
  .regulation of cell cycle
.mitotic cell cycle
.G2/M transition of mitotic cell cycle
.N/A .transcriptional repressor complex
.nucleoplasm
84 EBI-741037,EBI-741158 WDYHV1  
  .cellular protein modification process .protein-N-terminal glutamine amidohydrolase activity .cytosol
.nucleus
85 EBI-741037,EBI-744859 ANKRD36BP1  
  .N/A .N/A .N/A
86 EBI-741037,EBI-740773 RBM41  
  .N/A .RNA binding
.nucleotide binding
.N/A
87 EBI-741037,EBI-2515330 FEM1C  
  .protein ubiquitination .N/A .cytoplasm
88 EBI-741037,EBI-2509913 TNIP3  
  .cellular response to lipopolysaccharide
.negative regulation of I-kappaB kinase/NF-kappaB signaling
.toll-like receptor 4 signaling pathway
  + 2 more...
.polyubiquitin binding .N/A
89 EBI-741037,EBI-2682299 ZMAT2  
  .N/A .zinc ion binding
.DNA binding
.nucleus
90 EBI-741037,EBI-741729 FRMD6  
  .cellular protein localization
.regulation of actin filament-based process
.apical constriction
.N/A .apical junction complex
.plasma membrane
.cytoskeleton
.cytoplasm
91 EBI-741037,EBI-2514922 RBM15  
  .placenta blood vessel development
.ventricular septum morphogenesis
.spleen development
  + 4 more...
.poly(A) RNA binding
.nucleotide binding
.nuclear membrane
.nucleoplasm
92 EBI-741037,EBI-726447 PKP4  
  .positive regulation of GTPase activity
.positive regulation of cytokinesis
.regulation of cell adhesion
  + 3 more...
.N/A .mitotic spindle
.spindle midzone
.perinuclear region of cytoplasm
  + 9 more...
93 EBI-741037,EBI-742638 TSNAX  
  .RNA phosphodiester bond hydrolysis, endonucleolytic
.cell differentiation
.protein transport
  + 3 more...
.metal ion binding
.poly(A) RNA binding
.sequence-specific DNA binding
  + 4 more...
.perinuclear region of cytoplasm
.cytosol
.Golgi apparatus
  + 2 more...
94 EBI-741037,EBI-1965777 ZKSCAN3  
  .negative regulation of cellular senescence
.positive regulation of transcription, DNA-templated
.negative regulation of transcription, DNA-templated
  + 4 more...
.metal ion binding
.sequence-specific DNA binding
.sequence-specific DNA binding transcription factor activity
  + 4 more...
.cytoplasm
.nucleus
95 EBI-741037,EBI-9658624 RHNO1  
  .cellular response to ionizing radiation
.positive regulation of G0 to G1 transition
.cellular response to UV
  + 2 more...
.N/A .chromosome
.nucleus
96 EBI-741037,EBI-741350 THAP7  
  .negative regulation of transcription, DNA-templated
.transcription, DNA-templated
.C2H2 zinc finger domain binding
.protein N-terminus binding
.metal ion binding
.DNA binding
.nuclear speck
.chromosome
97 EBI-741037,EBI-740781 TCHP  
  .negative regulation of cell growth
.apoptotic process
.N/A .apical cortex
.keratin filament
.plasma membrane
  + 3 more...
98 EBI-741037,EBI-744023 FAM103A1  
  .recruitment of mRNA capping enzyme to RNA polymerase II holoenzyme complex
.methylation
.7-methylguanosine mRNA capping
.poly(A) RNA binding
.RNA binding
.mRNA cap binding complex
.nucleus
99 EBI-741037,EBI-743265 ZNF426  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
100 EBI-741037,EBI-2125614 KIFC3  
  .epithelial cell-cell adhesion
.zonula adherens maintenance
.metabolic process
  + 3 more...
.ATPase activity
.ATP binding
.microtubule motor activity
.extracellular exosome
.cytoplasmic vesicle membrane
.zonula adherens
  + 4 more...
101 EBI-741037,EBI-744935 C20orf195  
  .N/A .N/A .extracellular exosome
102 EBI-741037,EBI-748391 SCNM1  
  .RNA splicing
.mRNA processing
.metal ion binding
.enzyme binding
.nuclear speck
.nucleolus
.nucleus
103 EBI-741037,EBI-541426 AP1M1  
  .membrane organization
.regulation of defense response to virus by virus
.endosome to melanosome transport
  + 5 more...
.N/A .extracellular exosome
.trans-Golgi network membrane
.clathrin-coated endocytic vesicle membrane
  + 6 more...
104 EBI-741037,EBI-745073 BEX2  
  .regulation of cell cycle
.regulation of apoptotic process
.cell cycle
.apoptotic process
.N/A .cytoplasm
.nucleus
105 EBI-741037,EBI-742953 DGCR6L  
  .N/A .N/A .nucleus
106 EBI-741037,EBI-741850 SMIM3  
  .N/A .N/A .integral component of membrane
107 EBI-741037,EBI-372911 SPATC1L  
  .N/A .N/A .N/A
108 EBI-741037,EBI-745878 KIAA1683  
  .N/A .N/A .mitochondrion
.nucleus
109 EBI-741037,EBI-751319 CARD9  
  .nucleotide-binding oligomerization domain containing signaling pathway
.defense response to virus
.defense response to Gram-positive bacterium
  + 17 more...
.CARD domain binding
.protein homodimerization activity
.plasma membrane
.cytosol
.cytoplasm
110 EBI-741037,EBI-2130266 RNF41  
  .positive regulation of reactive oxygen species metabolic process
.regulation of reactive oxygen species metabolic process
.regulation of establishment of cell polarity
  + 12 more...
.ubiquitin protein ligase activity
.protein tag
.Ral GTPase binding
  + 3 more...
.cytosol
111 EBI-741037,EBI-741626 FAM124B  
  .N/A .N/A .N/A
112 EBI-741037,EBI-742909 ARMC7  
  .N/A .N/A .cytoplasm
.nucleus
113 EBI-741037,EBI-747035 SH2D4A  
  .negative regulation of phosphatase activity .phosphatase binding .cytoplasm
114 EBI-741037,EBI-715389 C8orf33  
  .N/A .N/A .N/A
115 EBI-741037,EBI-712912 CBX8  
  .cellular protein metabolic process
.post-translational protein modification
.protein sumoylation
  + 3 more...
.methylated histone binding
.ubiquitin-protein transferase activity
.single-stranded RNA binding
.PRC1 complex
.PcG protein complex
.nucleoplasm
  + 3 more...
116 EBI-741037,EBI-740364 NEK6  
  .regulation of cellular senescence
.spindle assembly
.protein autophosphorylation
  + 13 more...
.protein kinase binding
.kinesin binding
.ATP binding
  + 3 more...
.nuclear speck
.microtubule
.cytosol
  + 4 more...
117 EBI-741037,EBI-2126733 HOMER2  
  .regulation of store-operated calcium entry
.chemical homeostasis within a tissue
.behavioral response to cocaine
  + 3 more...
.G-protein coupled glutamate receptor binding .neuronal postsynaptic density
.postsynaptic membrane
.apical part of cell
  + 8 more...
118 EBI-741037,EBI-10313866 C19orf66  
  .N/A .N/A .N/A
119 EBI-741037,EBI-746682 GNL3L  
  .ribosome biogenesis
.metabolic process
.poly(A) RNA binding
.GTP binding
.GTPase activity
.membrane
.mitochondrion
.cytoplasm
  + 3 more...
120 EBI-741037,EBI-2339898 FANCL  
  .regulation of cell proliferation
.gamete generation
.cellular response to DNA damage stimulus
  + 3 more...
.ubiquitin protein ligase activity
.ubiquitin protein ligase binding
.ligase activity
  + 2 more...
.Fanconi anaemia nuclear complex
.cytoplasm
.nucleoplasm
.nuclear envelope
121 EBI-741037,EBI-5666657 GPATCH2L  
  .N/A .N/A .N/A
122 EBI-741037,EBI-8643161 C1orf109  
  .N/A .N/A .N/A
123 EBI-741037,EBI-743375 CHCHD3  
  .mitochondrial fusion
.inner mitochondrial membrane organization
.negative regulation of transcription from RNA polymerase II promoter
.protein complex scaffold
.phosphatase binding
.RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
.extracellular exosome
.mitochondrial inner membrane
.mitochondrion
  + 2 more...
124 EBI-741037,EBI-3258000 TBC1D7  
  .negative regulation of cilium assembly
.activation of GTPase activity
.response to growth factor
  + 2 more...
.Rab GTPase binding
.GTPase activator activity
.ciliary basal body
.cytoplasmic vesicle
.cytoplasmic membrane-bounded vesicle
125 EBI-741037,EBI-745520 ZNF581  
  .transcription from RNA polymerase II promoter
.regulation of transcription from RNA polymerase II promoter
.metal ion binding
.RNA polymerase II regulatory region sequence-specific DNA binding
.nucleus
126 EBI-741037,EBI-743428 RCOR3  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.chromatin binding
.DNA binding
.nucleus
127 EBI-741037,EBI-745404 THAP10  
  .N/A .metal ion binding
.DNA binding
.N/A
128 EBI-741037,EBI-399246 MORF4L1  
  .histone H2A acetylation
.histone H4 acetylation
.regulation of growth
  + 6 more...
.protein N-terminus binding
.chromatin binding
.NuA4 histone acetyltransferase complex
.Sin3 complex
.nucleoplasm
129 EBI-741037,EBI-396137 CDC23  
  .protein K11-linked ubiquitination
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
.positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
  + 11 more...
.ubiquitin-protein transferase activity .cytosol
.anaphase-promoting complex
.nucleoplasm
.intracellular
130 EBI-741037,EBI-1105370 ZNF490  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.nucleus
131 EBI-741037,EBI-2602396 ABT1  
  .small-subunit processome assembly
.spinal cord motor neuron differentiation
.transcription from RNA polymerase II promoter
  + 4 more...
.poly(A) RNA binding
.transcription coactivator activity
.DNA binding
.nucleotide binding
.nucleolus
.transcription factor complex
.nucleus
132 EBI-741037,EBI-744066 SPATA2  
  .cell differentiation
.spermatogenesis
.multicellular organismal development
.N/A .cytoplasm
.nucleolus
.nucleus
133 EBI-741037,EBI-717201 SPG7  
  .anterograde axon cargo transport
.nervous system development
.mitochondrion organization
.proteolysis
.unfolded protein binding
.zinc ion binding
.peptidase activity
  + 2 more...
.mitochondrial membrane
.integral component of membrane
.mitochondrion
134 EBI-741037,EBI-749003 NIP7  
  .ribosome assembly .poly(A) RNA binding .nucleolus
135 EBI-741037,EBI-1104564 MEMO1  
  .regulation of microtubule-based process .N/A .cytosol
.nucleus
136 EBI-741037,EBI-634187 DYRK1B  
  .adipose tissue development
.positive regulation of transcription, DNA-templated
.myoblast fusion
.protein phosphorylation
.ATP binding
.protein tyrosine kinase activity
.protein serine/threonine/tyrosine kinase activity
  + 3 more...
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland91
ascites25
bone41
bone marrow82
brain17
cervix41
connective tissue6
embryonic tissue75
eye43
heart33
intestine64
kidney75
liver38
lung59
lymph22
lymph node44
mammary gland26
muscle9
ovary49
pancreas23
placenta38
prostate36
skin94
stomach52
testis13
thymus25
uterus68
vascular19
Health State
TissuesTPM*
normal25
adrenal tumor237
bladder carcinoma56
breast (mammary gland) tumor10
cervical tumor57
chondrosarcoma36
colorectal tumor71
gastrointestinal tumor59
germ cell tumor30
glioma37
kidney tumor72
leukemia63
liver tumor83
lung tumor29
lymphoma13
ovarian tumor52
pancreatic tumor47
primitive neuroectodermal tumor of the CNS47
prostate cancer9
retinoblastoma21
skin tumor135
soft tissue/muscle tissue tumor79
uterine tumor77
Developmental Stage
TissuesTPM*
adult34
embryoid body114
blastocyst81
fetus12
infant42
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue34.5
adrenal gland23.4
appendix12.1
bone marrow8
cerebral cortex15.9
colon14.3
duodenum13.4
esophagus12.4
gallbladder22.4
heart muscle16.8
kidney20.1
liver4
lung23.6
lymph node10.1
ovary29.2
pancreas6.7
placenta23.7
prostate29.5
salivary gland27.3
skin21.6
small intestine13.2
spleen25.3
stomach19.6
testis24.4
thyroid gland16.1
urinary bladder22.8
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*610454, gene) Leucine zipper, putative tumor suppressor 2; LZTS2OMIM


#424, YPRC/BPRC, Industry-University Research Center, Yonsei Univ., Seodaemun-gu, Seoul, Korea, 120-749
Tel: +82-2-2123-6626, Fax: +82-2-393-6589
2014-2019 (C) Yonsei Proteome Research Center