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> Protein (NX_Q9BSW2)
Protein (NX_Q9BSW2)
Protein
Gene SymbolCRACR2A to neXtProt (NX_Q9BSW2)
DescriptionEF-hand calcium-binding domain-containing protein 4B
Chromosome12
Location12p13.32 (3715799 ~ 3873985) to Ensembl
Sequene Features : Isoforms 2, Variants 86, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of calcium ion transport
.activation of store-operated calcium channel activity
.immune system process
.store-operated calcium entry
.calcium ion binding .membrane
.Golgi apparatus
.cytoplasm
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 86 1
2014-09-19protein level
2 65 1
2014-05-27protein level
2 65 1
2014-02-25protein level
2 63 1
2013-12-09protein level
2 54 1
2013-11-01protein level
2 50 1
2013-09-12protein level
2 50 1
2013-08-17protein level
2 50 1
2013-07-15protein level
2 41 1
2013-06-11protein level
2 41 1
2013-02-12protein level
2 23 0
2012-12-20protein level
2 22 0
2012-10-30protein level
2 23 0
2012-10-07protein level
2 23 0
2012-08-24protein level
2 21 0
2012-07-28protein level
2 21 0
2012-06-08protein level
2 22 0
2012-05-07protein level
2 22 0
2012-04-10protein level
2 22 0
2012-01-13protein level
2 15 0
2011-12-20protein level
2 15 0
2011-11-11protein level
2 15 0
2011-08-23protein level
2 15 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9BSW2-1
2 15 0 45563.4925
NX_Q9BSW2-2
15 15 0 83141.4471
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-739773,EBI-717810 AES  
  .positive regulation of anoikis
.negative regulation of canonical Wnt signaling pathway
.response to interleukin-1
  + 12 more...
.transcription corepressor activity .nucleus
2 EBI-739773,EBI-2340269 MKRN3  
  .protein ubiquitination .ligase activity
.zinc ion binding
.ribonucleoprotein complex
3 EBI-739773,EBI-448878 STIM1  
  .regulation of calcium ion transport
.activation of store-operated calcium channel activity
.blood coagulation
  + 2 more...
.microtubule plus-end binding
.identical protein binding
.calcium ion binding
.calcium channel regulator activity
.cortical endoplasmic reticulum
.integral component of endoplasmic reticulum membrane
.integral component of plasma membrane
  + 3 more...
4 EBI-739773,EBI-945833 NOTCH2NL  
  .cell differentiation
.multicellular organismal development
.Notch signaling pathway
.calcium ion binding .cytoplasm
.extracellular region
5 EBI-739773,EBI-2291476 ORAI1  
  .positive regulation of calcium ion transport
.regulation of calcium ion transport
.blood coagulation
  + 2 more...
.identical protein binding
.store-operated calcium channel activity
.protein complex
.membrane
.integral component of plasma membrane
.autophagic vacuole
6 EBI-739773,EBI-396137 CDC23  
  .protein K11-linked ubiquitination
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
.positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
  + 11 more...
.ubiquitin-protein transferase activity .cytosol
.anaphase-promoting complex
.nucleoplasm
.intracellular
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
blood16
bone27
brain1
embryonic tissue4
eye19
intestine8
lymph22
lymph node11
mouth30
muscle37
pancreas4
prostate15
thymus12
trachea135
Health State
TissuesTPM*
normal3
chondrosarcoma24
colorectal tumor8
head and neck tumor14
leukemia21
lymphoma13
prostate cancer9
retinoblastoma43
soft tissue/muscle tissue tumor23
Developmental Stage
TissuesTPM*
adult5
fetus3
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue2
appendix6.2
bone marrow8.6
colon17.1
duodenum5.9
esophagus1.2
gallbladder2.6
heart muscle2.2
lung2
lymph node6.5
ovary1.9
pancreas2.4
prostate7.7
salivary gland53
small intestine12.4
spleen5.1
stomach6
testis1.7
urinary bladder4.7
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowMedium
breastHigh
bronchusMedium
cerebellumLow
cerebral cortexMedium
cervix, uterineMedium
colonHigh
duodenumMedium
endometrium 1Medium
endometrium 2Medium
epididymisMedium
esophagusLow
fallopian tubeMedium
gallbladderMedium
heart muscleMedium
hippocampusLow
kidneyMedium
lateral ventricleLow
liverLow
lungMedium
lymph nodeLow
nasopharynxMedium
oral mucosaMedium
pancreasHigh
parathyroid glandMedium
placentaMedium
prostateHigh
rectumHigh
salivary glandHigh
seminal vesicleMedium
skeletal muscleMedium
skin 1Medium
skin 2Medium
small intestineMedium
smooth muscleLow
soft tissue 1Medium
soft tissue 2Medium
spleenMedium
stomach 1High
stomach 2High
testisMedium
thyroid glandLow
tonsilMedium
urinary bladderMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*614178, gene) Ef-hand calcium-binding domain-containing protein 4b; EFCAB4BOMIM


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