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> Protein (NX_Q9BT40)
Protein (NX_Q9BT40)
Protein
Gene SymbolINPP5K to neXtProt (NX_Q9BT40)
DescriptionInositol polyphosphate 5-phosphatase K
Chromosome17
Location17p13.3 (1397865 ~ 1420182) to Ensembl
Sequene Features : Isoforms 2, Variants 49, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of renal water transport
.negative regulation of glycogen (starch) synthase activity
.ruffle assembly
  + 35 more...
.inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity
.inositol-1,4,5-trisphosphate 5-phosphatase activity
.inositol trisphosphate phosphatase activity
  + 7 more...
.perinuclear region of cytoplasm
.neuron projection
.ruffle membrane
  + 8 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 49 0
2014-09-19protein level
2 38 0
2014-05-27protein level
2 38 0
2014-02-25protein level
2 34 0
2013-12-09protein level
2 23 0
2013-11-01protein level
2 22 0
2013-09-12protein level
2 22 0
2013-08-17protein level
2 22 0
2013-07-15protein level
2 19 0
2013-06-11protein level
2 19 0
2013-02-12protein level
2 14 0
2012-12-20protein level
2 14 0
2012-10-30protein level
2 18 0
2012-10-07protein level
2 18 0
2012-08-24protein level
2 17 0
2012-07-28protein level
2 17 0
2012-06-08protein level
2 24 0
2012-05-07protein level
2 22 0
2012-04-10protein level
2 22 0
2012-01-13protein level
2 17 0
2011-12-20protein level
2 17 0
2011-11-11protein level
2 17 0
2011-08-23protein level
2 17 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9BT40-1
2 17 0 51057.7238
NX_Q9BT40-2
1 17 0 42756.3678
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-749162,EBI-712181 MAD2L1BP  
  .regulation of exit from mitosis
.mitotic cell cycle checkpoint
.N/A .intracellular membrane-bounded organelle
.spindle
.cytoplasm
  + 2 more...
2 EBI-749162,EBI-948001 KRT31  
  .epidermis development .structural constituent of cytoskeleton .extracellular exosome
.intermediate filament
.extracellular space
3 EBI-749162,EBI-739832 LNX1  
  .protein homooligomerization
.protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.ligase activity
.zinc ion binding
.ubiquitin-protein transferase activity
.cytoplasm
4 EBI-749162,EBI-743099 FATE1  
  .N/A .N/A .integral component of membrane
.endoplasmic reticulum
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites75
bladder33
blood81
bone55
brain83
cervix123
connective tissue33
embryonic tissue28
eye181
heart44
intestine51
kidney23
liver4
lung47
lymph90
lymph node211
mammary gland46
mouth75
muscle47
ovary19
pancreas93
parathyroid48
pituitary gland242
placenta91
prostate52
skin71
spleen149
stomach10
testis73
thymus37
thyroid107
tonsil58
trachea96
uterus34
vascular58
Health State
TissuesTPM*
normal77
breast (mammary gland) tumor32
cervical tumor28
chondrosarcoma108
colorectal tumor71
gastrointestinal tumor25
germ cell tumor45
glioma46
head and neck tumor74
kidney tumor43
leukemia52
liver tumor10
lung tumor38
lymphoma83
non-neoplasia93
ovarian tumor26
pancreatic tumor133
primitive neuroectodermal tumor of the CNS62
prostate cancer9
retinoblastoma86
skin tumor87
uterine tumor11
Developmental Stage
TissuesTPM*
adult68
embryoid body28
blastocyst32
neonate32
fetus86
infant85
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue38.2
adrenal gland16.9
appendix19.2
bone marrow38.2
cerebral cortex18.3
colon18.4
duodenum15
esophagus18.1
gallbladder20.2
heart muscle21
kidney16.5
liver8
lung37.8
lymph node25.9
ovary18.8
pancreas12.6
placenta22.5
prostate19
salivary gland16.1
skin29.9
small intestine16.6
spleen28.1
stomach19.6
testis32.6
thyroid gland35.5
urinary bladder21.2
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*607875, gene) Skeletal muscle- and kidney-enriched inositol phosphataseOMIM


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