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> Protein (NX_Q9BT49)
Protein (NX_Q9BT49)
Protein
Gene SymbolTHAP7 to neXtProt (NX_Q9BT49)
DescriptionTHAP domain-containing protein 7
Chromosome22
Location22q11.21 (21353393 ~ 21356485) to Ensembl
Sequene Features : Isoforms 1, Variants 27, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of transcription, DNA-templated
.transcription, DNA-templated
.C2H2 zinc finger domain binding
.protein N-terminus binding
.metal ion binding
.DNA binding
.nuclear speck
.chromosome
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 27 0
2014-09-19protein level
1 23 0
2014-05-27protein level
1 23 0
2014-02-25protein level
1 23 0
2013-12-09protein level
1 15 0
2013-11-01protein level
1 15 0
2013-09-12protein level
1 15 0
2013-08-17protein level
1 15 0
2013-07-15protein level
1 9 0
2013-06-11protein level
1 9 0
2013-02-12protein level
1 8 1
2012-12-20protein level
1 7 1
2012-10-30protein level
1 8 1
2012-10-07protein level
1 8 1
2012-08-24protein level
1 4 1
2012-07-28protein level
1 4 1
2012-06-08protein level
1 4 1
2012-05-07protein level
1 4 1
2012-04-10protein level
1 4 1
2012-01-13protein level
1 5 1
2011-12-20protein level
1 5 1
2011-11-11protein level
1 5 1
2011-08-23protein level
1 5 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9BT49-1
12 0 0 34392.2779
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-741350,EBI-748961 CCNDBP1  
  .regulation of cell cycle
.cell cycle
.N/A .cytoplasm
.nucleoplasm
.nucleus
2 EBI-741350,EBI-10171774 KRTAP10-8  
  .N/A .N/A .keratin filament
3 EBI-741350,EBI-1053182 SET  
  .negative regulation of transcription, DNA-templated
.negative regulation of neuron apoptotic process
.negative regulation of catalytic activity
  + 9 more...
.histone binding
.protein phosphatase type 2A regulator activity
.protein phosphatase inhibitor activity
.DNA binding
.perinuclear region of cytoplasm
.protein complex
.cytosol
  + 4 more...
4 EBI-741350,EBI-618309 GOLGA2  
  .negative regulation of protein binding
.mitotic cell cycle
.syntaxin binding
.protein kinase binding
.Golgi cisterna membrane
.ER to Golgi transport vesicle
.cis-Golgi network
  + 4 more...
5 EBI-741350,EBI-355744 TRAF2  
  .positive regulation of extrinsic apoptotic signaling pathway
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
.negative regulation of neuron death
  + 35 more...
.sphingolipid binding
.identical protein binding
.thioesterase binding
  + 10 more...
.IRE1-TRAF2-ASK1 complex
.TRAF2-GSTP1 complex
.membrane raft
  + 7 more...
6 EBI-741350,EBI-359224 TRAF1  
  .regulation of extrinsic apoptotic signaling pathway
.positive regulation of NF-kappaB transcription factor activity
.signal transduction
  + 2 more...
.thioesterase binding
.ubiquitin protein ligase binding
.zinc ion binding
.tumor necrosis factor receptor binding
.cytoplasm
7 EBI-741350,EBI-714158 PIN1  
  .negative regulation of cell motility
.negative regulation of ERK1 and ERK2 cascade
.regulation of pathway-restricted SMAD protein phosphorylation
  + 11 more...
.phosphothreonine binding
.phosphoserine binding
.GTPase activating protein binding
  + 2 more...
.midbody
.nuclear speck
.cytoplasm
  + 2 more...
8 EBI-741350,EBI-948001 KRT31  
  .epidermis development .structural constituent of cytoskeleton .extracellular exosome
.intermediate filament
.extracellular space
9 EBI-741350,EBI-742948 MTUS2  
  .N/A .protein homodimerization activity
.microtubule binding
.microtubule
.cytoplasm
.nucleus
10 EBI-741350,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
11 EBI-741350,EBI-945833 NOTCH2NL  
  .cell differentiation
.multicellular organismal development
.Notch signaling pathway
.calcium ion binding .cytoplasm
.extracellular region
12 EBI-741350,EBI-713786 PHC2  
  .cellular protein metabolic process
.post-translational protein modification
.protein sumoylation
  + 2 more...
.identical protein binding
.zinc ion binding
.DNA binding
.PRC1 complex
.PcG protein complex
.nucleoplasm
  + 2 more...
13 EBI-741350,EBI-739832 LNX1  
  .protein homooligomerization
.protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.ligase activity
.zinc ion binding
.ubiquitin-protein transferase activity
.cytoplasm
14 EBI-741350,EBI-741037 LZTS2  
  .negative regulation of protein localization to nucleus
.negative regulation of canonical Wnt signaling pathway
.spindle midzone assembly
  + 7 more...
.N/A .midbody
.microtubule
.centrosome
.cytoplasm
15 EBI-741350,EBI-1105213 TFIP11  
  .biomineral tissue development
.RNA processing
.regulation of transcription, DNA-templated
  + 2 more...
.DNA binding .catalytic step 2 spliceosome
.U2-type post-mRNA release spliceosomal complex
.nuclear speck
  + 3 more...
16 EBI-741350,EBI-10172526 MID2  
  .negative regulation of viral release from host cell
.positive regulation of NF-kappaB transcription factor activity
.positive regulation of sequence-specific DNA binding transcription factor activity
  + 6 more...
.phosphoprotein binding
.protein heterodimerization activity
.protein homodimerization activity
  + 3 more...
.extracellular exosome
.microtubule
.cytoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland121
ascites50
blood73
bone97
bone marrow20
brain67
cervix41
connective tissue40
embryonic tissue32
esophagus99
eye76
heart89
intestine21
kidney52
larynx42
liver48
lung74
lymph67
lymph node55
mammary gland19
mouth30
muscle56
nerve64
ovary68
pancreas60
parathyroid242
pituitary gland181
placenta21
prostate79
salivary gland98
skin56
spleen18
stomach41
testis59
thyroid21
trachea19
uterus34
vascular19
Health State
TissuesTPM*
normal53
adrenal tumor79
breast (mammary gland) tumor10
cervical tumor57
chondrosarcoma36
colorectal tumor17
esophageal tumor115
gastrointestinal tumor50
germ cell tumor41
glioma111
head and neck tumor37
kidney tumor43
leukemia74
liver tumor20
lung tumor107
lymphoma110
non-neoplasia82
ovarian tumor39
pancreatic tumor95
primitive neuroectodermal tumor of the CNS251
prostate cancer105
retinoblastoma86
skin tumor87
soft tissue/muscle tissue tumor39
uterine tumor55
Developmental Stage
TissuesTPM*
adult42
embryoid body28
blastocyst32
neonate32
fetus66
infant42
juvenile125
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue10.3
adrenal gland12.3
appendix9.2
bone marrow11.3
cerebral cortex10.3
colon9.8
duodenum11.9
esophagus9.3
gallbladder11.4
heart muscle12.5
kidney12.3
liver7
lung12.7
lymph node15.6
ovary19.8
pancreas9.4
placenta8.4
prostate15.6
salivary gland21.9
skin13
small intestine11.5
spleen16.9
stomach13.9
testis23.2
thyroid gland14.3
urinary bladder12.3
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*609518, gene) Thap domain-containing protein 7; THAP7OMIM


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