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> Protein (NX_Q9BT92)
Protein (NX_Q9BT92)
Protein
Gene SymbolTCHP to neXtProt (NX_Q9BT92)
DescriptionTrichoplein keratin filament-binding protein
Chromosome12
Location12q24.11 (110338069 ~ 110421646) to Ensembl
Sequene Features : Isoforms 1, Variants 72, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of cell growth
.apoptotic process
.N/A .apical cortex
.keratin filament
.plasma membrane
  + 3 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 72 0
2014-09-19protein level
1 59 0
2014-05-27protein level
1 59 0
2014-02-25protein level
1 59 0
2013-12-09protein level
1 39 0
2013-11-01protein level
1 39 0
2013-09-12protein level
1 39 0
2013-08-17protein level
1 39 0
2013-07-15protein level
1 30 0
2013-06-11protein level
1 30 0
2013-02-12protein level
1 19 0
2012-12-20protein level
1 20 0
2012-10-30protein level
1 25 0
2012-10-07protein level
1 25 0
2012-08-24protein level
1 25 0
2012-07-28protein level
1 25 0
2012-06-08protein level
1 26 0
2012-05-07protein level
1 22 0
2012-04-10protein level
1 22 0
2012-01-13protein level
1 12 0
2011-12-20protein level
1 12 0
2011-11-11protein level
1 12 0
2011-08-23protein level
1 12 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9BT92-1
20 0 0 61033.975
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-740781,EBI-2548868 CCDC172  
  .N/A .N/A .N/A
2 EBI-740781,EBI-719493 TRIM27  
  .negative regulation of viral release from host cell
.negative regulation of interleukin-2 secretion
.negative regulation of calcium ion import
  + 17 more...
.metal ion binding
.ligase activity
.zinc ion binding
  + 4 more...
.nuclear membrane
.PML body
.membrane
  + 6 more...
3 EBI-740781,EBI-739566 KRT15  
  .activation of mitophagy in response to mitochondrial depolarization
.epidermis development
.scaffold protein binding
.structural constituent of cytoskeleton
.extracellular exosome
.intermediate filament
.nucleus
4 EBI-740781,EBI-1181367 CDR2  
  .N/A .N/A .cytoplasm
5 EBI-740781,EBI-2340269 MKRN3  
  .protein ubiquitination .ligase activity
.zinc ion binding
.ribonucleoprotein complex
6 EBI-740781,EBI-8641936 NAB2  
  .regulation of epidermis development
.myelination
.negative regulation of transcription from RNA polymerase III promoter
  + 5 more...
.transcription corepressor activity .nucleus
7 EBI-740781,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
8 EBI-740781,EBI-2548751 MIPOL1  
  .N/A .N/A .nucleus
9 EBI-740781,EBI-740680 DYDC1  
  .N/A .N/A .N/A
10 EBI-740781,EBI-741037 LZTS2  
  .negative regulation of protein localization to nucleus
.negative regulation of canonical Wnt signaling pathway
.spindle midzone assembly
  + 7 more...
.N/A .midbody
.microtubule
.centrosome
.cytoplasm
11 EBI-740781,EBI-10249760 NDOR1  
  .oxidation-reduction process
.small molecule metabolic process
.cellular response to menadione
  + 2 more...
.NADP binding
.flavin adenine dinucleotide binding
.oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
  + 4 more...
.perinuclear region of cytoplasm
.intermediate filament cytoskeleton
.cytosol
  + 2 more...
12 EBI-740781,EBI-744782 NME7  
  .left/right pattern formation
.ciliary receptor clustering involved in smoothened signaling pathway
.intraciliary transport
  + 6 more...
.metal ion binding
.ATP binding
.nucleoside diphosphate kinase activity
.ciliary basal body
.centrosome
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites50
bladder33
blood8
bone27
brain9
cervix20
connective tissue6
embryonic tissue18
eye14
intestine21
kidney56
liver29
lung17
lymph node44
mammary gland19
muscle47
ovary19
pancreas23
parathyroid48
prostate5
salivary gland49
skin33
spleen18
stomach20
testis2
thymus12
thyroid21
tonsil58
uterus17
Health State
TissuesTPM*
normal14
breast (mammary gland) tumor21
cervical tumor28
chondrosarcoma12
colorectal tumor26
gastrointestinal tumor16
germ cell tumor15
glioma9
head and neck tumor7
kidney tumor87
leukemia10
liver tumor20
lung tumor38
non-neoplasia31
ovarian tumor26
pancreatic tumor9
primitive neuroectodermal tumor of the CNS7
prostate cancer9
retinoblastoma21
skin tumor55
soft tissue/muscle tissue tumor79
uterine tumor11
Developmental Stage
TissuesTPM*
adult12
embryoid body28
blastocyst16
fetus8
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue7.7
adrenal gland9.6
appendix12.5
bone marrow7
cerebral cortex12.3
colon9.4
duodenum10.5
esophagus14.7
gallbladder10.4
heart muscle6.7
kidney7.9
liver4
lung10.4
lymph node13.6
ovary9.7
pancreas4
placenta8.1
prostate11.3
salivary gland11.7
skin28.4
small intestine11.6
spleen17.1
stomach11.7
testis14.6
thyroid gland11.1
urinary bladder11.8
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*612654, gene) Trichoplein; TCHPOMIM


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