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> Protein (NX_Q9BTA9)
Protein (NX_Q9BTA9)
Protein
Gene SymbolWAC to neXtProt (NX_Q9BTA9)
DescriptionWW domain-containing adapter protein with coiled-coil
Chromosome10
Location10p12.1 (28821422 ~ 28912041) to Ensembl
Sequene Features : Isoforms 4, Variants 86, PTMs 14 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.histone H2B conserved C-terminal lysine ubiquitination
.positive regulation of transcription, DNA-templated
.G1 DNA damage checkpoint
  + 5 more...
.chromatin binding
.RNA polymerase II core binding
.nuclear speck
.spliceosomal complex
.nucleoplasm
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
4 86 14
2014-09-19protein level
4 67 14
2014-05-27protein level
4 67 14
2014-02-25protein level
4 67 14
2013-12-09protein level
4 57 14
2013-11-01protein level
4 57 12
2013-09-12protein level
4 57 13
2013-08-17protein level
4 57 13
2013-07-15protein level
4 32 13
2013-06-11protein level
4 32 13
2013-02-12protein level
4 17 45
2012-12-20protein level
4 18 45
2012-10-30protein level
4 20 45
2012-10-07protein level
4 20 14
2012-08-24protein level
4 20 14
2012-07-28protein level
4 20 14
2012-06-08protein level
4 23 14
2012-05-07protein level
4 19 14
2012-04-10protein level
4 19 14
2012-01-13protein level
4 14 14
2011-12-20protein level
4 14 14
2011-11-11protein level
4 14 12
2011-08-23protein level
4 14 12
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9BTA9-1
0 26 0 70680.9359
NX_Q9BTA9-2
0 23 0 65442.4603
NX_Q9BTA9-3
2 14 0 47687.3973
NX_Q9BTA9-5
2 20 0 59468.3568
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-749118,EBI-739566 KRT15  
  .activation of mitophagy in response to mitochondrial depolarization
.epidermis development
.scaffold protein binding
.structural constituent of cytoskeleton
.extracellular exosome
.intermediate filament
.nucleus
2 EBI-749118,EBI-466029 HTT  
  .negative regulation of extrinsic apoptotic signaling pathway
.iron ion homeostasis
.L-glutamate import
  + 38 more...
.diazepam binding
.beta-tubulin binding
.dynein intermediate chain binding
  + 6 more...
.protein complex
.cytoplasmic vesicle membrane
.dendrite
  + 11 more...
3 EBI-749118,EBI-359224 TRAF1  
  .regulation of extrinsic apoptotic signaling pathway
.positive regulation of NF-kappaB transcription factor activity
.signal transduction
  + 2 more...
.thioesterase binding
.ubiquitin protein ligase binding
.zinc ion binding
.tumor necrosis factor receptor binding
.cytoplasm
4 EBI-749118,EBI-2007911 NFE2L2  
  .positive regulation of reactive oxygen species metabolic process
.negative regulation of endothelial cell apoptotic process
.regulation of removal of superoxide radicals
  + 19 more...
.transcription regulatory region DNA binding
.protein domain specific binding
.sequence-specific DNA binding transcription factor activity
  + 5 more...
.protein-DNA complex
.plasma membrane
.cytosol
  + 5 more...
5 EBI-10298216,EBI-742948 MTUS2  
  .N/A .protein homodimerization activity
.microtubule binding
.microtubule
.cytoplasm
.nucleus
6 EBI-749118,EBI-1643885 KLC3  
  .axon cargo transport .microtubule motor activity .neuron projection
.ciliary rootlet
.motile cilium
  + 3 more...
7 EBI-749118,EBI-2939487 SYTL5  
  .calcium ion-dependent exocytosis of neurotransmitter
.regulation of calcium ion-dependent exocytosis
.synaptic vesicle exocytosis
  + 2 more...
.clathrin binding
.syntaxin binding
.calcium-dependent phospholipid binding
.calcium ion binding
.exocytic vesicle
.plasma membrane
8 EBI-749118,EBI-740680 DYDC1  
  .N/A .N/A .N/A
9 EBI-749118,EBI-9641546 AKAP9  
  .positive regulation of potassium ion transmembrane transporter activity
.regulation of heart rate by cardiac conduction
.cellular response to cAMP
  + 11 more...
.ion channel binding
.protein complex scaffold
.potassium channel regulator activity
.receptor binding
.intracellular membrane-bounded organelle
.ciliary basal body
.voltage-gated potassium channel complex
  + 5 more...
10 EBI-749118,EBI-765817 TRAF3IP3  
  .N/A .N/A .integral component of membrane
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland242
ascites125
bladder267
blood302
bone167
bone marrow164
brain160
cervix82
connective tissue87
ear186
embryonic tissue103
esophagus99
eye172
heart78
intestine137
kidney123
larynx85
liver92
lung125
lymph90
lymph node178
mammary gland165
mouth90
muscle84
nerve128
ovary187
pancreas112
parathyroid48
pharynx98
pituitary gland121
placenta204
prostate68
salivary gland49
skin75
spleen149
stomach104
testis82
thymus87
thyroid171
trachea77
umbilical cord217
uterus129
vascular77
Health State
TissuesTPM*
normal155
adrenal tumor395
bladder carcinoma341
breast (mammary gland) tumor96
cervical tumor115
chondrosarcoma132
colorectal tumor79
esophageal tumor115
gastrointestinal tumor135
germ cell tumor186
glioma186
head and neck tumor74
kidney tumor101
leukemia338
liver tumor93
lung tumor87
lymphoma110
non-neoplasia124
ovarian tumor196
pancreatic tumor57
primitive neuroectodermal tumor of the CNS157
prostate cancer77
retinoblastoma21
skin tumor47
soft tissue/muscle tissue tumor119
uterine tumor122
Developmental Stage
TissuesTPM*
adult143
embryoid body100
blastocyst48
neonate193
fetus195
infant127
juvenile89
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue49.3
adrenal gland53.9
appendix59.8
bone marrow95.9
cerebral cortex61
colon54.6
duodenum48.8
esophagus68.4
gallbladder67
heart muscle56.2
kidney51.7
liver32.2
lung54.3
lymph node80.4
ovary83
pancreas34.6
placenta71.6
prostate50.5
salivary gland44.3
skin45.1
small intestine53
spleen69.9
stomach50.3
testis67.5
thyroid gland91.2
urinary bladder80
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected


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