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> Protein (NX_Q9BTE3)
Protein (NX_Q9BTE3)
Protein
Gene SymbolMCMBP to neXtProt (NX_Q9BTE3)
DescriptionMini-chromosome maintenance complex-binding protein
Chromosome10
Location10q26.11 (121588972 ~ 121652068) to Ensembl
Sequene Features : Isoforms 3, Variants 58, PTMs 16 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cell division
.mitotic nuclear division
.sister chromatid cohesion
.DNA-dependent DNA replication
.chromatin binding .plasma membrane
.cytoplasm
.nucleoplasm
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 58 16
2014-09-19protein level
3 50 16
2014-05-27protein level
3 50 16
2014-02-25protein level
3 50 16
2013-12-09protein level
3 41 16
2013-11-01protein level
3 38 12
2013-09-12protein level
3 38 12
2013-08-17protein level
3 38 12
2013-07-15protein level
3 23 5
2013-06-11protein level
3 23 5
2013-02-12protein level
3 8 13
2012-12-20protein level
3 6 13
2012-10-30protein level
3 9 13
2012-10-07protein level
3 9 5
2012-08-24protein level
3 6 5
2012-07-28protein level
3 6 5
2012-06-08protein level
3 9 5
2012-05-07protein level
3 9 5
2012-04-10protein level
3 9 5
2012-01-13protein level
3 9 5
2011-12-20protein level
3 9 5
2011-11-11protein level
3 9 4
2011-08-23protein level
3 9 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9BTE3-1
1 29 0 72933.5781
NX_Q9BTE3-2
0 30 0 72702.4746
NX_Q9BTE3-3
0 21 0 52618.8458
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-749378,EBI-374980 CDC7  
  .cell division
.cell cycle phase transition
.peptidyl-serine phosphorylation
  + 10 more...
.metal ion binding
.kinase activity
.ATP binding
  + 2 more...
.intercellular bridge
.microtubule cytoskeleton
.cytoplasm
  + 2 more...
2 EBI-749378,EBI-355153 MCM3  
  .DNA strand elongation involved in DNA replication
.DNA replication initiation
.DNA replication
  + 2 more...
.ATP binding
.DNA helicase activity
.DNA binding
.perinuclear region of cytoplasm
.intracellular membrane-bounded organelle
.MCM complex
  + 5 more...
3 EBI-749378,EBI-374938 MCM4  
  .DNA strand elongation involved in DNA replication
.DNA replication initiation
.DNA unwinding involved in DNA replication
  + 3 more...
.ATP binding
.single-stranded DNA binding
.DNA helicase activity
.MCM complex
.membrane
.nucleoplasm
.nucleus
4 EBI-749378,EBI-359410 MCM5  
  .DNA strand elongation involved in DNA replication
.DNA replication initiation
.DNA replication
  + 2 more...
.ATP binding
.DNA replication origin binding
.chromatin binding
.DNA helicase activity
.MCM complex
.membrane
.nucleoplasm
.nucleus
5 EBI-749378,EBI-355924 MCM7  
  .cellular response to epidermal growth factor stimulus
.response to drug
.regulation of phosphorylation
  + 8 more...
.ATP binding
.single-stranded DNA binding
.DNA helicase activity
.MCM complex
.membrane
.cytosol
  + 3 more...
6 EBI-749378,EBI-374819 MCM2  
  .cellular response to interleukin-4
.cell cycle
.nucleosome assembly
  + 6 more...
.metal ion binding
.ATP binding
.DNA replication origin binding
  + 2 more...
.MCM complex
.microtubule cytoskeleton
.cytoplasm
  + 4 more...
7 EBI-749378,EBI-374900 MCM6  
  .DNA strand elongation involved in DNA replication
.DNA replication initiation
.DNA unwinding involved in DNA replication
  + 3 more...
.identical protein binding
.ATP binding
.single-stranded DNA binding
.DNA helicase activity
.MCM complex
.nucleoplasm
.nucleus
8 EBI-749378,EBI-747500 GINS4  
  .DNA duplex unwinding
.DNA strand elongation involved in DNA replication
.DNA replication initiation
  + 3 more...
.N/A .replication fork protection complex
.cytoplasm
.nucleoplasm
.GINS complex
9 EBI-749378,EBI-739759 PRTFDC1  
  .nucleoside metabolic process .protein homodimerization activity
.magnesium ion binding
.nucleotide binding
.cytosol
10 EBI-749378,EBI-8756095 MCM8  
  .male gamete generation
.female gamete generation
.cellular response to DNA damage stimulus
  + 5 more...
.ATP binding
.helicase activity
.DNA binding
.MCM8-MCM9 complex
.nucleoplasm
.nucleus
11 EBI-749378,EBI-80718 SMC3  
  .cell division
.cellular protein metabolic process
.post-translational protein modification
  + 12 more...
.protein heterodimerization activity
.dynein binding
.ATP binding
  + 2 more...
.nuclear meiotic cohesin complex
.meiotic cohesin complex
.nuclear matrix
  + 12 more...
12 EBI-749378,EBI-747491 GINS2  
  .mitotic DNA replication initiation
.DNA duplex unwinding
.DNA strand elongation involved in DNA replication
  + 2 more...
.N/A .replication fork protection complex
.nucleoplasm
.GINS complex
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland60
ascites125
bladder66
blood16
bone195
bone marrow20
brain39
cervix82
connective tissue33
embryonic tissue126
esophagus49
eye71
heart44
intestine34
kidney66
larynx170
liver48
lung26
lymph22
lymph node167
mammary gland52
mouth30
muscle37
ovary59
pancreas60
parathyroid145
placenta60
prostate63
skin47
spleen112
stomach73
testis36
thymus12
thyroid107
umbilical cord145
uterus116
vascular77
Health State
TissuesTPM*
normal55
breast (mammary gland) tumor64
cervical tumor115
chondrosarcoma181
colorectal tumor35
esophageal tumor57
gastrointestinal tumor92
germ cell tumor64
glioma18
head and neck tumor67
kidney tumor72
leukemia21
liver tumor41
lung tumor9
lymphoma83
non-neoplasia62
ovarian tumor39
pancreatic tumor95
primitive neuroectodermal tumor of the CNS118
prostate cancer67
retinoblastoma107
skin tumor71
soft tissue/muscle tissue tumor79
uterine tumor55
Developmental Stage
TissuesTPM*
adult57
embryoid body157
blastocyst130
neonate64
fetus53
infant212
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue26.8
adrenal gland15.1
appendix32.8
bone marrow16.1
cerebral cortex13.6
colon28.5
duodenum20.9
esophagus33.3
gallbladder24.7
heart muscle18.6
kidney20.5
liver15.3
lung24.8
lymph node33.1
ovary28.6
pancreas12.1
placenta38.4
prostate18.7
salivary gland13.2
skin22.5
small intestine23.4
spleen23.3
stomach22.8
testis24.8
thyroid gland26
urinary bladder29.6
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*610909, gene) Minichromosome maintenance complex-binding protein; MCMBPOMIM


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