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> Protein (NX_Q9BTU6)
Protein (NX_Q9BTU6)
Protein
Gene SymbolPI4K2A to neXtProt (NX_Q9BTU6)
DescriptionPhosphatidylinositol 4-kinase type 2-alpha
Chromosome10
Location10q24.2 (99344131 ~ 99436191) to Ensembl
Sequene Features : Isoforms 1, Variants 39, PTMs 16 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.activation of mitophagy in response to mitochondrial depolarization
.phosphatidylinositol phosphorylation
.small molecule metabolic process
  + 2 more...
.AP-3 adaptor complex binding
.ATP binding
.1-phosphatidylinositol 4-kinase activity
.magnesium ion binding
.membrane raft
.host cell presynaptic membrane
.neuronal cell body
  + 15 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 39 16
2014-09-19protein level
1 33 16
2014-05-27protein level
1 33 16
2014-02-25protein level
1 33 16
2013-12-09protein level
1 26 16
2013-11-01protein level
1 25 10
2013-09-12protein level
1 25 10
2013-08-17protein level
1 25 10
2013-07-15protein level
1 16 9
2013-06-11protein level
1 16 9
2013-02-12protein level
1 11 9
2012-12-20protein level
1 11 9
2012-10-30protein level
1 13 9
2012-10-07protein level
1 13 9
2012-08-24protein level
1 13 9
2012-07-28protein level
1 13 9
2012-06-08protein level
1 13 9
2012-05-07protein level
1 9 9
2012-04-10protein level
1 9 9
2012-01-13protein level
1 4 9
2011-12-20protein level
1 4 9
2011-11-11protein level
1 4 9
2011-08-23protein level
1 4 9
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9BTU6-1
28 0 0 53988.4533
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-3239392,EBI-1564678 ITCH  
  .regulation of protein deubiquitination
.protein K48-linked ubiquitination
.protein K63-linked ubiquitination
  + 21 more...
.ubiquitin protein ligase activity
.CXCR chemokine receptor binding
.ribonucleoprotein complex binding
  + 2 more...
.extracellular exosome
.cytoplasmic vesicle
.membrane
  + 5 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
bladder66
blood16
bone55
brain32
cervix61
connective tissue46
embryonic tissue46
esophagus49
eye52
heart22
intestine17
kidney23
liver9
lung56
lymph node11
mammary gland19
mouth15
muscle9
ovary59
pancreas23
pituitary gland60
placenta31
prostate52
skin52
spleen18
stomach41
testis82
thyroid64
umbilical cord72
uterus56
vascular58
Health State
TissuesTPM*
normal40
adrenal tumor79
cervical tumor86
chondrosarcoma96
colorectal tumor8
esophageal tumor57
gastrointestinal tumor42
germ cell tumor41
glioma46
head and neck tumor37
kidney tumor29
leukemia10
liver tumor10
lung tumor58
lymphoma13
non-neoplasia20
ovarian tumor65
pancreatic tumor47
primitive neuroectodermal tumor of the CNS94
prostate cancer19
retinoblastoma43
skin tumor71
soft tissue/muscle tissue tumor23
uterine tumor33
Developmental Stage
TissuesTPM*
adult41
embryoid body42
blastocyst97
neonate64
fetus48
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue9.3
adrenal gland15.1
appendix9.6
bone marrow14
cerebral cortex11.3
colon7.4
duodenum8.5
esophagus13.5
gallbladder15.1
heart muscle10.6
kidney10.7
liver6.4
lung11.5
lymph node10.6
ovary8
pancreas3.8
placenta17.1
prostate6.8
salivary gland5.2
skin9.7
small intestine7.6
spleen12.1
stomach6.3
testis10.8
thyroid gland9.9
urinary bladder13.6
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*609763, gene) Phosphatidylinositol 4-kinase, type 2, alpha; PI4K2AOMIM


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