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> Protein (NX_Q9BUZ4)
Protein (NX_Q9BUZ4)
Protein
Gene SymbolTRAF4 to neXtProt (NX_Q9BUZ4)
DescriptionTNF receptor-associated factor 4
Chromosome17
Location17q11.2 (27071002 ~ 27077974) to Ensembl
Sequene Features : Isoforms 2, Variants 35, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of protein homodimerization activity
.positive regulation of JNK cascade
.positive regulation of protein kinase activity
  + 6 more...
.WW domain binding
.thioesterase binding
.ubiquitin protein ligase binding
  + 4 more...
.perinuclear region of cytoplasm
.tight junction
.plasma membrane
  + 3 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 35 3
2014-09-19protein level
2 24 3
2014-05-27protein level
2 24 3
2014-02-25protein level
2 24 3
2013-12-09protein level
2 19 3
2013-11-01protein level
2 19 2
2013-09-12protein level
2 19 2
2013-08-17protein level
2 19 2
2013-07-15protein level
2 13 1
2013-06-11protein level
2 13 1
2013-02-12protein level
2 7 1
2012-12-20protein level
2 7 1
2012-10-30protein level
2 7 1
2012-10-07protein level
2 7 1
2012-08-24protein level
2 6 1
2012-07-28protein level
2 6 1
2012-06-08protein level
2 7 1
2012-05-07protein level
2 4 1
2012-04-10protein level
2 4 1
2012-01-13protein level
2 6 1
2011-12-20protein level
2 6 1
2011-11-11protein level
2 6 1
2011-08-23protein level
2 6 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9BUZ4-1
15 9 0 53507.2542
NX_Q9BUZ4-2
1 9 0 22826.2323
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-3650647,EBI-10177044 NPIPA7  
  .N/A .N/A .N/A
2 EBI-3650647,EBI-743923 WWP2  
  .regulation of potassium ion transmembrane transporter activity
.protein K63-linked ubiquitination
.protein autoubiquitination
  + 13 more...
.ligase activity
.transcription factor binding
.ubiquitin-protein transferase activity
.RNA polymerase II transcription factor binding
.extracellular exosome
.membrane
.cytoplasm
  + 2 more...
3 EBI-3650647,EBI-780467 NOS1AP  
  .positive regulation of peptidyl-cysteine S-nitrosylation
.positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
.regulation of generation of L-type calcium current
  + 13 more...
.nitric-oxide synthase binding .perinuclear region of cytoplasm
.sarcoplasmic reticulum membrane
.Z disc
  + 3 more...
4 EBI-3650647,EBI-356983 UBL4A  
  .tail-anchored membrane protein insertion into ER membrane
.transport
.cellular protein modification process
.ubiquitin-like protein transferase activity .BAT3 complex
.cytosol
5 EBI-3650647,EBI-1640965 ZNF3  
  .leukocyte activation
.cell differentiation
.multicellular organismal development
  + 2 more...
.identical protein binding
.zinc ion binding
.DNA binding
.nucleus
6 EBI-3650647,EBI-1383454 TYK2  
  .regulation of type I interferon-mediated signaling pathway
.type I interferon signaling pathway
.innate immune response
  + 8 more...
.ATP binding
.growth hormone receptor binding
.non-membrane spanning protein tyrosine kinase activity
.protein tyrosine kinase activity
.extracellular exosome
.extrinsic component of cytoplasmic side of plasma membrane
.cytoskeleton
  + 3 more...
7 EBI-3650647,EBI-347462 QARS  
  .gene expression
.brain development
.glutaminyl-tRNA aminoacylation
.tRNA aminoacylation for protein translation
.ATP binding
.glutamine-tRNA ligase activity
.cytosol
.mitochondrial matrix
.cytoplasm
8 EBI-3650647,EBI-80140 SUMO1  
  .protein localization to nuclear pore
.regulation of interferon-gamma-mediated signaling pathway
.interferon-gamma-mediated signaling pathway
  + 13 more...
.poly(A) RNA binding
.ubiquitin protein ligase binding
.SUMO transferase activity
.transcription factor binding
.synapse
.nuclear membrane
.dendrite
  + 8 more...
9 EBI-3650647,EBI-723426 MRPL28  
  .mitochondrial translational termination
.mitochondrial translational elongation
.mitochondrial translational initiation
  + 3 more...
.poly(A) RNA binding
.structural constituent of ribosome
.mitochondrial ribosome
.mitochondrial inner membrane
.mitochondrion
  + 2 more...
10 EBI-3650647,EBI-10175039 TP53BP2  
  .positive regulation of execution phase of apoptosis
.intrinsic apoptotic signaling pathway by p53 class mediator
.negative regulation of cell cycle
  + 7 more...
.NF-kappaB binding
.identical protein binding
.SH3/SH2 adaptor activity
.p53 binding
.perinuclear region of cytoplasm
.cytoplasm
.nucleus
11 EBI-3650647,EBI-358049 BYSL  
  .cell proliferation
.female pregnancy
.cell adhesion
  + 2 more...
.poly(A) RNA binding .apical part of cell
.intracellular membrane-bounded organelle
.membrane
  + 3 more...
12 EBI-3650647,EBI-948001 KRT31  
  .epidermis development .structural constituent of cytoskeleton .extracellular exosome
.intermediate filament
.extracellular space
13 EBI-3650647,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
14 EBI-3650647,EBI-10262361 REXO1L1P  
  .N/A .exonuclease activity
.nucleic acid binding
.cytoplasm
.nucleus
15 EBI-3650647,EBI-10172004 HOMEZ  
  .transcription, DNA-templated
.negative regulation of transcription from RNA polymerase II promoter
.transcription corepressor activity
.sequence-specific DNA binding transcription factor activity
.DNA binding
.cytoplasm
.nucleolus
.nucleus
16 EBI-3650647,EBI-10267507 UBL4B  
  .positive regulation of protein targeting to mitochondrion .N/A .cytoplasm
17 EBI-3650647,EBI-744695 BANP  
  .negative regulation of protein catabolic process
.protein localization to nucleus
.chromatin modification
  + 4 more...
.DNA binding .nucleoplasm
18 EBI-3650647,EBI-742750 BAHD1  
  .negative regulation of transcription, DNA-templated
.heterochromatin assembly
.transcription, DNA-templated
.chromatin silencing
.chromatin binding
.transcription regulatory region sequence-specific DNA binding
.chromatin silencing complex
.nucleoplasm
.chromatin
19 EBI-3650647,EBI-715381 SPDL1  
  .cell division
.protein localization to kinetochore
.spindle checkpoint
  + 4 more...
.kinetochore binding
.enzyme binding
.cytosol
.microtubule organizing center
.nucleus
  + 2 more...
20 EBI-3650647,EBI-742157 WWP1  
  .transmembrane transport
.viral entry into host cell
.negative regulation of transcription, DNA-templated
  + 6 more...
.ligase activity
.ubiquitin-protein transferase activity
.extracellular exosome
.plasma membrane
.cytosol
  + 3 more...
21 EBI-3650647,EBI-739467 GORASP2  
  .organelle organization
.mitotic cell cycle
.N/A .membrane
.Golgi apparatus
.Golgi membrane
22 EBI-3650647,EBI-9845742 SMURF1  
  .positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.positive regulation of dendrite extension
.activation of mitophagy in response to mitochondrial depolarization
  + 18 more...
.R-SMAD binding
.I-SMAD binding
.ubiquitin protein ligase activity
  + 4 more...
.extracellular exosome
.neuronal cell body
.axon
  + 5 more...
23 EBI-3650647,EBI-720563 ISYNA1  
  .small molecule metabolic process
.inositol phosphate metabolic process
.phospholipid biosynthetic process
.inositol biosynthetic process
.inositol-3-phosphate synthase activity .cytosol
24 EBI-3650647,EBI-8637516 ALKBH4  
  .cleavage furrow ingression
.actomyosin structure organization
.protein demethylation
  + 2 more...
.metal ion binding
.demethylase activity
.oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
.actin binding
.contractile ring
.midbody
.cytoplasm
.nucleus
25 EBI-3650647,EBI-3258000 TBC1D7  
  .negative regulation of cilium assembly
.activation of GTPase activity
.response to growth factor
  + 2 more...
.Rab GTPase binding
.GTPase activator activity
.ciliary basal body
.cytoplasmic vesicle
.cytoplasmic membrane-bounded vesicle
26 EBI-3650647,EBI-745520 ZNF581  
  .transcription from RNA polymerase II promoter
.regulation of transcription from RNA polymerase II promoter
.metal ion binding
.RNA polymerase II regulatory region sequence-specific DNA binding
.nucleus
27 EBI-3650647,EBI-714455 WBP11  
  .RNA splicing
.mRNA processing
.rRNA processing
.WW domain binding
.poly(A) RNA binding
.protein phosphatase type 1 regulator activity
.single-stranded DNA binding
.nuclear speck
.cytoplasm
.nucleoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites50
bladder33
blood81
bone97
bone marrow20
brain41
cervix41
connective tissue26
embryonic tissue126
eye57
heart22
intestine99
kidney33
liver48
lung41
lymph67
lymph node77
mammary gland46
muscle37
nerve128
ovary118
pancreas28
pharynx24
placenta38
prostate94
salivary gland98
skin18
spleen37
stomach240
testis18
thymus12
thyroid21
tonsil58
uterus94
vascular19
Health State
TissuesTPM*
normal50
bladder carcinoma284
breast (mammary gland) tumor64
chondrosarcoma60
colorectal tumor124
gastrointestinal tumor126
germ cell tumor60
glioma83
head and neck tumor22
kidney tumor43
leukemia95
liver tumor20
lung tumor77
lymphoma96
non-neoplasia41
ovarian tumor118
pancreatic tumor47
primitive neuroectodermal tumor of the CNS110
prostate cancer154
retinoblastoma64
skin tumor7
soft tissue/muscle tissue tumor55
uterine tumor155
Developmental Stage
TissuesTPM*
adult72
embryoid body157
blastocyst113
fetus68
infant42
juvenile179
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue9.1
adrenal gland13.7
appendix18.9
bone marrow36.9
cerebral cortex15
colon27.4
duodenum64.8
esophagus17.4
gallbladder26.5
heart muscle2
kidney23.5
liver16.3
lung28.1
lymph node29.9
ovary5.4
pancreas12.7
placenta22.1
prostate23.5
salivary gland46.9
skin10
small intestine49
spleen17
stomach42.2
testis15.8
thyroid gland31.2
urinary bladder38.1
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*602464, gene) Tnf receptor-associated factor 4; TRAF4OMIM


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