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> Protein (NX_Q9BVG8)
Protein (NX_Q9BVG8)
Protein
Gene SymbolKIFC3 to neXtProt (NX_Q9BVG8)
DescriptionKinesin-like protein KIFC3
Chromosome16
Location16q21 (57792129 ~ 57896957) to Ensembl
Sequene Features : Isoforms 5, Variants 85, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.epithelial cell-cell adhesion
.zonula adherens maintenance
.metabolic process
  + 3 more...
.ATPase activity
.ATP binding
.microtubule motor activity
.extracellular exosome
.cytoplasmic vesicle membrane
.zonula adherens
  + 4 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
5 85 0
2014-09-19protein level
4 68 0
2014-05-27protein level
4 68 0
2014-02-25protein level
4 68 0
2013-12-09protein level
4 45 0
2013-11-01protein level
4 42 0
2013-09-12protein level
4 42 0
2013-08-17protein level
4 43 0
2013-07-15protein level
4 31 0
2013-06-11protein level
4 31 0
2013-02-12protein level
4 15 3
2012-12-20protein level
4 17 3
2012-10-30protein level
4 19 3
2012-10-07protein level
4 19 1
2012-08-24protein level
4 12 1
2012-07-28protein level
4 11 1
2012-06-08protein level
4 5 1
2012-05-07protein level
4 5 1
2012-04-10protein level
3 5 1
2012-01-13protein level
3 5 1
2011-12-20protein level
3 5 1
2011-11-11protein level
3 5 1
2011-08-23protein level
3 6 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9BVG8-2
0 43 1 91953.9785
NX_Q9BVG8-3
0 43 1 92717.4465
NX_Q9BVG8-4
1 32 0 71562.576
NX_Q9BVG8-5
0 35 1 77041.2766
NX_Q9BVG8-6
1 43 1 94217.8734
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-2125614,EBI-8646694 DCX  
  .dendrite morphogenesis
.axon extension
.protein autophosphorylation
  + 8 more...
.protein kinase binding
.calcium-dependent protein serine/threonine kinase activity
.microtubule binding
  + 2 more...
.neuron projection
.microtubule associated complex
.microtubule
  + 4 more...
2 EBI-2125614,EBI-748664 HSBP1  
  .regulation of cellular response to heat
.endodermal cell differentiation
.cellular response to heat
  + 2 more...
.transcription corepressor activity .cytoskeleton
.nucleoplasm
.nucleus
3 EBI-2125614,EBI-743272 USP2  
  .regulation of proteasomal protein catabolic process
.protein stabilization
.positive regulation of skeletal muscle tissue development
  + 11 more...
.metal ion binding
.ubiquitin protein ligase binding
.cyclin binding
  + 2 more...
.perinuclear region of cytoplasm
.cell cortex
.centrosome
  + 2 more...
4 EBI-2125614,EBI-1055693 RAD51D  
  .strand invasion
.reciprocal meiotic recombination
.DNA repair
  + 2 more...
.gamma-tubulin binding
.DNA-dependent ATPase activity
.ATP binding
  + 2 more...
.Rad51B-Rad51C-Rad51D-XRCC2 complex
.centrosome
.cytoplasm
  + 3 more...
5 EBI-2125614,EBI-1215612 FCHSD2  
  .N/A .N/A .N/A
6 EBI-2125614,EBI-7543896 SCEL  
  .keratinocyte differentiation
.embryo development
.epidermis development
.zinc ion binding .extracellular exosome
.cytoplasm
.cornified envelope
7 EBI-2125614,EBI-1757866 MOS  
  .negative regulation of metaphase/anaphase transition of meiotic cell cycle
.establishment of meiotic spindle orientation
.protein autophosphorylation
  + 6 more...
.ATP binding
.MAP kinase kinase kinase activity
.protein serine/threonine kinase activity
.cytoplasm
8 EBI-2125614,EBI-702198 KRT6A  
  .activation of mitophagy in response to mitochondrial depolarization
.wound healing
.cell differentiation
  + 3 more...
.structural constituent of cytoskeleton .extracellular exosome
.keratin filament
.membrane
.nucleus
9 EBI-2125614,EBI-740907 KRT6B  
  .ectoderm development .structural constituent of cytoskeleton .extracellular exosome
.keratin filament
10 EBI-2125614,EBI-742756 KRT19  
  .cell differentiation involved in embryonic placenta development
.sarcomere organization
.response to estrogen
.viral process
.structural constituent of muscle
.structural constituent of cytoskeleton
.cell periphery
.extracellular exosome
.costamere
  + 5 more...
11 EBI-2125614,EBI-702187 KRT5  
  .cell junction assembly
.hemidesmosome assembly
.epidermis development
.scaffold protein binding
.structural constituent of cytoskeleton
.extracellular exosome
.keratin filament
.membrane
  + 6 more...
12 EBI-2125614,EBI-719493 TRIM27  
  .negative regulation of viral release from host cell
.negative regulation of interleukin-2 secretion
.negative regulation of calcium ion import
  + 17 more...
.metal ion binding
.ligase activity
.zinc ion binding
  + 4 more...
.nuclear membrane
.PML body
.membrane
  + 6 more...
13 EBI-2125614,EBI-1170906 ATF2  
  .positive regulation of mitochondrial membrane permeability involved in apoptotic process
.adipose tissue development
.stress-activated MAPK cascade
  + 27 more...
.metal ion binding
.cAMP response element binding
.protein kinase binding
  + 13 more...
.site of double-strand break
.mitochondrial outer membrane
.cytoplasm
  + 2 more...
14 EBI-2125614,EBI-717634 ZNF20  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
15 EBI-2125614,EBI-739566 KRT15  
  .activation of mitophagy in response to mitochondrial depolarization
.epidermis development
.scaffold protein binding
.structural constituent of cytoskeleton
.extracellular exosome
.intermediate filament
.nucleus
16 EBI-2125614,EBI-372273 PSMB1  
  .positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
  + 23 more...
.threonine-type endopeptidase activity
.endopeptidase activity
.extracellular exosome
.proteasome core complex
.cytosol
  + 4 more...
17 EBI-2125614,EBI-355924 MCM7  
  .cellular response to epidermal growth factor stimulus
.response to drug
.regulation of phosphorylation
  + 8 more...
.ATP binding
.single-stranded DNA binding
.DNA helicase activity
.MCM complex
.membrane
.cytosol
  + 3 more...
18 EBI-2125614,EBI-3505701 SOX5  
  .positive regulation of mesenchymal stem cell differentiation
.cellular response to transforming growth factor beta stimulus
.positive regulation of cartilage development
  + 10 more...
.transcription regulatory region DNA binding
.sequence-specific DNA binding transcription factor activity
.sequence-specific DNA binding RNA polymerase II transcription factor activity
.nuclear transcription factor complex
19 EBI-2125614,EBI-740098 TRIM23  
  .positive regulation of catalytic activity
.protein ubiquitination
.viral process
.small GTPase mediated signal transduction
.identical protein binding
.GDP binding
.ligase activity
  + 5 more...
.extracellular exosome
.lysosomal membrane
.nucleus
.Golgi membrane
20 EBI-2125614,EBI-347978 NUP62  
  .regulation of cellular response to heat
.transmembrane transport
.mRNA transport
  + 34 more...
.thyroid hormone receptor binding
.ubiquitin binding
.SH2 domain binding
  + 3 more...
.Flemming body
.pore complex
.intracellular membrane-bounded organelle
  + 7 more...
21 EBI-2125614,EBI-765407 BCL6  
  .negative regulation of cellular senescence
.positive regulation of cellular component movement
.regulation of immune response
  + 32 more...
.metal ion binding
.sequence-specific DNA binding
.chromatin DNA binding
  + 4 more...
.nucleus
22 EBI-2125614,EBI-2564105 KRT6C  
  .intermediate filament cytoskeleton organization .structural molecule activity .extracellular exosome
.keratin filament
.intermediate filament
23 EBI-2125614,EBI-1383852 PRKAA2  
  .regulation of energy homeostasis
.membrane organization
.fatty acid homeostasis
  + 31 more...
.[acetyl-CoA carboxylase] kinase activity
.[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity
.metal ion binding
  + 7 more...
.AMP-activated protein kinase complex
.cytosol
.cytoplasm
.nucleoplasm
24 EBI-2125614,EBI-1048159 MFAP1  
  .extracellular matrix organization .poly(A) RNA binding .extracellular region
.microfibril
25 EBI-2125614,EBI-2834260 ESRRG  
  .positive regulation of transcription, DNA-templated
.gene expression
.transcription initiation from RNA polymerase II promoter
.regulation of transcription, DNA-templated
.AF-2 domain binding
.zinc ion binding
.steroid binding
  + 4 more...
.nucleoplasm
26 EBI-2125614,EBI-1181367 CDR2  
  .N/A .N/A .cytoplasm
27 EBI-2125614,EBI-10192698 CREB5  
  .adipose tissue development
.positive regulation of transcription, DNA-templated
.fat cell differentiation
.transcription from RNA polymerase II promoter
.metal ion binding
.sequence-specific DNA binding
.sequence-specific DNA binding transcription factor activity
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.extracellular exosome
.nucleus
28 EBI-2125614,EBI-748597 CCDC67  
  .multi-ciliated epithelial cell differentiation
.de novo centriole assembly
.cell projection organization
.N/A .deuterosome
.cytoplasm
29 EBI-2125614,EBI-746238 CDK18  
  .N/A .ATP binding
.cyclin-dependent protein serine/threonine kinase activity
.N/A
30 EBI-2125614,EBI-717810 AES  
  .positive regulation of anoikis
.negative regulation of canonical Wnt signaling pathway
.response to interleukin-1
  + 12 more...
.transcription corepressor activity .nucleus
31 EBI-2125614,EBI-618309 GOLGA2  
  .negative regulation of protein binding
.mitotic cell cycle
.syntaxin binding
.protein kinase binding
.Golgi cisterna membrane
.ER to Golgi transport vesicle
.cis-Golgi network
  + 4 more...
32 EBI-2125614,EBI-355744 TRAF2  
  .positive regulation of extrinsic apoptotic signaling pathway
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
.negative regulation of neuron death
  + 35 more...
.sphingolipid binding
.identical protein binding
.thioesterase binding
  + 10 more...
.IRE1-TRAF2-ASK1 complex
.TRAF2-GSTP1 complex
.membrane raft
  + 7 more...
33 EBI-2125614,EBI-712105 ITGB3BP  
  .apoptotic signaling pathway
.cell division
.neurotrophin TRK receptor signaling pathway
  + 10 more...
.protein C-terminus binding
.signal transducer activity
.membrane
.cytosol
.cytoplasm
  + 3 more...
34 EBI-2125614,EBI-715074 DCTN2  
  .melanosome transport
.antigen processing and presentation of exogenous peptide antigen via MHC class II
.cell proliferation
  + 5 more...
.spectrin binding
.motor activity
.extracellular exosome
.vesicle
.growth cone
  + 8 more...
35 EBI-2125614,EBI-357849 TNIP1  
  .modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade
.negative regulation of ERK1 and ERK2 cascade
.positive regulation of inflammatory response
  + 9 more...
.mitogen-activated protein kinase binding .cytoplasm
.nucleus
.intracellular
36 EBI-2125614,EBI-948001 KRT31  
  .epidermis development .structural constituent of cytoskeleton .extracellular exosome
.intermediate filament
.extracellular space
37 EBI-2125614,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
38 EBI-2125614,EBI-10257016 ZNF572  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
39 EBI-2125614,EBI-744506 FAM124A  
  .N/A .N/A .N/A
40 EBI-2125614,EBI-747107 SIAH1  
  .positive regulation of intrinsic apoptotic signaling pathway
.neuron apoptotic process
.proteasome-mediated ubiquitin-dependent protein catabolic process
  + 11 more...
.ubiquitin protein ligase activity
.identical protein binding
.ligase activity
  + 3 more...
.beta-catenin destruction complex
.plasma membrane
.cytosol
  + 3 more...
41 EBI-2125614,EBI-355471 CCDC28A  
  .N/A .N/A .N/A
42 EBI-2125614,EBI-713786 PHC2  
  .cellular protein metabolic process
.post-translational protein modification
.protein sumoylation
  + 2 more...
.identical protein binding
.zinc ion binding
.DNA binding
.PRC1 complex
.PcG protein complex
.nucleoplasm
  + 2 more...
43 EBI-2125614,EBI-10181988 CEP57L1  
  .microtubule anchoring .N/A .microtubule
.microtubule organizing center
.cytoplasm
44 EBI-2125614,EBI-6872807 SYCE1  
  .cell division
.synaptonemal complex assembly
.N/A .central element
45 EBI-2125614,EBI-5655540 CLIP4  
  .N/A .N/A .N/A
46 EBI-2125614,EBI-3439227 ZGPAT  
  .negative regulation of transcription, DNA-templated
.negative regulation of epidermal growth factor-activated receptor activity
.negative regulation of transcription from RNA polymerase II promoter
.metal ion binding
.sequence-specific DNA binding
.sequence-specific DNA binding transcription factor activity
  + 2 more...
.nucleus
47 EBI-2125614,EBI-625509 ZNF655  
  .negative regulation of G1/S transition of mitotic cell cycle
.regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.cytoplasm
.nucleolus
.nucleus
48 EBI-2125614,EBI-954696 TCEANC  
  .regulation of DNA-templated transcription, elongation
.regulation of transcription from RNA polymerase II promoter
.transcription, DNA-templated
.DNA binding .nucleus
49 EBI-2125614,EBI-741724 SPERT  
  .N/A .N/A .cytoplasmic membrane-bounded vesicle
50 EBI-2125614,EBI-10269733 ICA1L  
  .N/A .N/A .N/A
51 EBI-2125614,EBI-725997 TRIM41  
  .protein ubiquitination .ligase activity
.zinc ion binding
.cytoplasm
.nucleolus
52 EBI-2125614,EBI-746981 TSR2  
  .maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) .N/A .nucleus
53 EBI-2125614,EBI-455078 SMARCE1  
  .negative regulation of transcription, DNA-templated
.ATP-dependent chromatin remodeling
.metabolic process
  + 4 more...
.protein N-terminus binding
.ligand-dependent nuclear receptor binding
.N-acetyltransferase activity
  + 4 more...
.nBAF complex
.npBAF complex
.protein complex
  + 6 more...
54 EBI-2125614,EBI-742740 ZBTB8A  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
55 EBI-2125614,EBI-726510 LENG1  
  .N/A .N/A .N/A
56 EBI-2125614,EBI-2514791 HAUS1  
  .cell division
.centrosome organization
.spindle assembly
.mitotic nuclear division
.N/A .HAUS complex
.microtubule
.centrosome
  + 2 more...
57 EBI-2125614,EBI-465804 DTNBP1  
  .membrane organization
.regulation of dopamine receptor signaling pathway
.platelet dense granule organization
  + 11 more...
.N/A .postsynaptic membrane
.dendritic spine
.neuron projection
  + 14 more...
58 EBI-2125614,EBI-748884 LIN37  
  .regulation of cell cycle
.mitotic cell cycle
.G2/M transition of mitotic cell cycle
.N/A .transcriptional repressor complex
.nucleoplasm
59 EBI-2125614,EBI-10171416 CCDC136  
  .N/A .N/A .integral component of membrane
.mitochondrion
60 EBI-2125614,EBI-743488 CEP170P1  
  .N/A .identical protein binding .N/A
61 EBI-2125614,EBI-346882 TSG101  
  .positive regulation of viral budding via host ESCRT complex
.regulation of viral budding via host ESCRT complex
.regulation of extracellular exosome assembly
  + 21 more...
.calcium-dependent protein binding
.virion binding
.ubiquitin binding
  + 4 more...
.extracellular exosome
.late endosome membrane
.endosome membrane
  + 8 more...
62 EBI-2125614,EBI-741037 LZTS2  
  .negative regulation of protein localization to nucleus
.negative regulation of canonical Wnt signaling pathway
.spindle midzone assembly
  + 7 more...
.N/A .midbody
.microtubule
.centrosome
.cytoplasm
63 EBI-2125614,EBI-2130429 TRIM54  
  .cell differentiation
.multicellular organismal development
.signal transduction
  + 2 more...
.zinc ion binding
.signal transducer activity
.Z disc
.microtubule associated complex
.microtubule
64 EBI-2125614,EBI-928842 NDEL1  
  .neuron projection extension
.neurofilament cytoskeleton organization
.centrosome localization
  + 20 more...
.oligopeptidase activity
.microtubule binding
.neurofilament cytoskeleton
.axon hillock
.cell leading edge
  + 10 more...
65 EBI-2125614,EBI-739467 GORASP2  
  .organelle organization
.mitotic cell cycle
.N/A .membrane
.Golgi apparatus
.Golgi membrane
66 EBI-2125614,EBI-712912 CBX8  
  .cellular protein metabolic process
.post-translational protein modification
.protein sumoylation
  + 3 more...
.methylated histone binding
.ubiquitin-protein transferase activity
.single-stranded RNA binding
.PRC1 complex
.PcG protein complex
.nucleoplasm
  + 3 more...
67 EBI-2125614,EBI-394607 MED4  
  .positive regulation of transcription, DNA-templated
.androgen receptor signaling pathway
.intracellular steroid hormone receptor signaling pathway
  + 3 more...
.thyroid hormone receptor binding
.vitamin D receptor binding
.ligand-dependent nuclear receptor transcription coactivator activity
  + 3 more...
.mediator complex
.membrane
.nucleoplasm
.nucleus
68 EBI-2125614,EBI-2339898 FANCL  
  .regulation of cell proliferation
.gamete generation
.cellular response to DNA damage stimulus
  + 3 more...
.ubiquitin protein ligase activity
.ubiquitin protein ligase binding
.ligase activity
  + 2 more...
.Fanconi anaemia nuclear complex
.cytoplasm
.nucleoplasm
.nuclear envelope
69 EBI-2125614,EBI-8643161 C1orf109  
  .N/A .N/A .N/A
70 EBI-2125614,EBI-743598 ABI2  
  .positive regulation of Arp2/3 complex-mediated actin nucleation
.peptidyl-tyrosine phosphorylation
.Rac protein signal transduction
  + 5 more...
.proline-rich region binding
.protein complex binding
.ubiquitin protein ligase binding
  + 4 more...
.SCAR complex
.filopodium
.lamellipodium
  + 3 more...
71 EBI-2125614,EBI-748350 RTDR1  
  .N/A .N/A .N/A
72 EBI-2125614,EBI-10172526 MID2  
  .negative regulation of viral release from host cell
.positive regulation of NF-kappaB transcription factor activity
.positive regulation of sequence-specific DNA binding transcription factor activity
  + 6 more...
.phosphoprotein binding
.protein heterodimerization activity
.protein homodimerization activity
  + 3 more...
.extracellular exosome
.microtubule
.cytoplasm
73 EBI-2125614,EBI-10322527 ZNF180  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
blood8
bone41
brain42
cervix20
connective tissue26
embryonic tissue32
eye95
intestine8
kidney61
larynx85
liver38
lung89
mammary gland59
mouth30
muscle47
nerve128
pancreas93
placenta63
prostate5
salivary gland98
skin71
stomach177
testis222
thymus12
thyroid128
trachea38
uterus21
Health State
TissuesTPM*
normal53
breast (mammary gland) tumor53
cervical tumor28
chondrosarcoma84
colorectal tumor8
gastrointestinal tumor143
germ cell tumor15
glioma55
head and neck tumor67
kidney tumor29
leukemia10
liver tumor72
lung tumor136
non-neoplasia20
pancreatic tumor47
primitive neuroectodermal tumor of the CNS15
retinoblastoma21
skin tumor103
soft tissue/muscle tissue tumor23
uterine tumor22
Developmental Stage
TissuesTPM*
adult51
embryoid body85
fetus26
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue15.1
adrenal gland13.9
appendix17.7
bone marrow2.5
cerebral cortex12.2
colon3.5
duodenum19.8
esophagus15
gallbladder12.3
heart muscle20.6
kidney48.9
liver9.4
lung29.8
lymph node5.2
ovary7.7
pancreas23.2
placenta18.3
prostate9.9
salivary gland9.7
skin42.8
small intestine20.7
spleen9.9
stomach8.4
testis39.2
thyroid gland26.1
urinary bladder13.1
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*604535, gene) Kinesin family member c3; KIFC3OMIM


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