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> Protein (NX_Q9BVL2)
Protein (NX_Q9BVL2)
Protein
Gene SymbolNUPL1 to neXtProt (NX_Q9BVL2)
DescriptionNucleoporin p58/p45
Chromosome13
Location13q12.13 (25875662 ~ 25923938) to Ensembl
Sequene Features : Isoforms 3, Variants 62, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of cellular response to heat
.transmembrane transport
.mRNA transport
  + 17 more...
.nucleocytoplasmic transporter activity .nuclear membrane
.nuclear pore
.nuclear envelope
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 62 4
2014-09-19protein level
3 49 4
2014-05-27protein level
3 49 4
2014-02-25protein level
3 47 4
2013-12-09protein level
3 36 4
2013-11-01protein level
3 36 3
2013-09-12protein level
3 36 3
2013-08-17protein level
3 36 3
2013-07-15protein level
3 25 1
2013-06-11protein level
3 25 1
2013-02-12protein level
2 10 2
2012-12-20protein level
2 10 2
2012-10-30protein level
2 13 2
2012-10-07protein level
2 13 1
2012-08-24protein level
2 13 1
2012-07-28protein level
2 13 1
2012-06-08protein level
2 13 1
2012-05-07protein level
2 12 1
2012-04-10protein level
2 12 1
2012-01-13protein level
2 5 1
2011-12-20protein level
2 5 1
2011-11-11protein level
2 5 0
2011-08-23protein level
2 5 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9BVL2-1
0 12 0 60859.5082
NX_Q9BVL2-2
1 11 0 50179.3764
NX_Q9BVL2-3
1 11 0 59716.8569
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-2811583,EBI-347978 NUP62  
  .regulation of cellular response to heat
.transmembrane transport
.mRNA transport
  + 34 more...
.thyroid hormone receptor binding
.ubiquitin binding
.SH2 domain binding
  + 3 more...
.Flemming body
.pore complex
.intracellular membrane-bounded organelle
  + 7 more...
2 EBI-2811583,EBI-466029 HTT  
  .negative regulation of extrinsic apoptotic signaling pathway
.iron ion homeostasis
.L-glutamate import
  + 38 more...
.diazepam binding
.beta-tubulin binding
.dynein intermediate chain binding
  + 6 more...
.protein complex
.cytoplasmic vesicle membrane
.dendrite
  + 11 more...
3 EBI-2811583,EBI-359224 TRAF1  
  .regulation of extrinsic apoptotic signaling pathway
.positive regulation of NF-kappaB transcription factor activity
.signal transduction
  + 2 more...
.thioesterase binding
.ubiquitin protein ligase binding
.zinc ion binding
.tumor necrosis factor receptor binding
.cytoplasm
4 EBI-2811583,EBI-741048 NUP54  
  .regulation of cellular response to heat
.transmembrane transport
.mRNA transport
  + 17 more...
.nucleocytoplasmic transporter activity .nuclear membrane
.cytoplasm
.nucleoplasm
  + 2 more...
5 EBI-2811583,EBI-742038 ABI3  
  .regulation of cell migration
.movement of cell or subcellular component
.N/A .lamellipodium
.membrane
.cytoplasm
.intracellular
6 EBI-2811583,EBI-10173939 UBQLN1  
  .regulation of autophagic vacuole assembly
.positive regulation of ER-associated ubiquitin-dependent protein catabolic process
.regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
  + 8 more...
.identical protein binding
.polyubiquitin binding
.kinase binding
.perinuclear region of cytoplasm
.protein complex
.aggresome
  + 6 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland30
ascites25
bladder133
blood106
bone13
bone marrow20
brain45
connective tissue33
embryonic tissue65
eye4
heart33
intestine77
kidney4
larynx127
liver24
lung8
lymph45
lymph node11
mammary gland33
mouth136
muscle122
nerve128
ovary187
pancreas28
parathyroid145
pharynx319
pituitary gland181
placenta7
prostate10
salivary gland197
skin75
spleen37
stomach10
testis344
thymus125
thyroid193
trachea115
umbilical cord217
uterus47
vascular154
Health State
TissuesTPM*
normal69
adrenal tumor79
breast (mammary gland) tumor53
chondrosarcoma12
colorectal tumor8
gastrointestinal tumor33
germ cell tumor87
glioma27
head and neck tumor261
kidney tumor72
leukemia201
liver tumor20
lymphoma69
non-neoplasia20
ovarian tumor249
pancreatic tumor47
primitive neuroectodermal tumor of the CNS39
prostate cancer57
retinoblastoma258
skin tumor71
soft tissue/muscle tissue tumor31
uterine tumor44
Developmental Stage
TissuesTPM*
adult4
embryoid body71
blastocyst65
neonate128
fetus1
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue12.2
adrenal gland16
appendix20.3
bone marrow23
cerebral cortex16.8
colon14.4
duodenum12.1
esophagus15.1
gallbladder16.3
heart muscle11.9
kidney14.7
liver9.5
lung21.1
lymph node22.7
ovary18.7
pancreas6.7
placenta23.2
prostate17.5
salivary gland8
skin14.9
small intestine12.1
spleen12.8
stomach14.8
testis58.7
thyroid gland22.6
urinary bladder16.3
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*607615, gene) Nucleoporin-like 1; NUPL1OMIM


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