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> Protein (NX_Q9BWG6)
Protein (NX_Q9BWG6)
Protein
Gene SymbolSCNM1 to neXtProt (NX_Q9BWG6)
DescriptionSodium channel modifier 1
Chromosome1
Location1q21.3 (151129140 ~ 151142773) to Ensembl
Sequene Features : Isoforms 3, Variants 36, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.RNA splicing
.mRNA processing
.metal ion binding
.enzyme binding
.nuclear speck
.nucleolus
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 36 4
2014-09-19protein level
3 27 4
2014-05-27protein level
3 27 4
2014-02-25protein level
2 27 4
2013-12-09protein level
2 23 4
2013-11-01protein level
2 22 4
2013-09-12protein level
2 22 4
2013-08-17protein level
2 22 4
2013-07-15protein level
2 18 4
2013-06-11protein level
2 18 4
2013-02-12protein level
2 11 6
2012-12-20protein level
2 11 6
2012-10-30protein level
2 13 6
2012-10-07protein level
2 13 3
2012-08-24protein level
2 11 3
2012-07-28protein level
2 11 3
2012-06-08protein level
2 13 3
2012-05-07protein level
2 8 3
2012-04-10protein level
2 8 3
2012-01-13protein level
2 2 3
2011-12-20protein level
2 2 3
2011-11-11protein level
2 2 3
2011-08-23protein level
2 2 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9BWG6-1
0 12 0 25933.1643
NX_Q9BWG6-2
0 10 0 21873.0919
NX_Q9BWG6-3
2 7 0 18873.7731
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-748391,EBI-740019 PLSCR1  
  .positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity
.regulation of Fc receptor mediated stimulatory signaling pathway
.defense response to virus
  + 11 more...
.CD4 receptor binding
.enzyme binding
.phospholipid scramblase activity
  + 5 more...
.extracellular exosome
.membrane raft
.extracellular matrix
  + 7 more...
2 EBI-748391,EBI-10176632 ZBTB14  
  .negative regulation of transcription, DNA-templated
.transcription from RNA polymerase II promoter
.negative regulation of transcription from RNA polymerase II promoter
.metal ion binding
.transcription regulatory region DNA binding
.sequence-specific DNA binding
  + 2 more...
.cytoplasm
.nucleoplasm
.nucleus
3 EBI-748391,EBI-1047263 KRT38  
  .N/A .structural molecule activity .extracellular exosome
.intermediate filament
4 EBI-748391,EBI-741602 TRIM37  
  .aggresome assembly
.protein autoubiquitination
.positive regulation of NF-kappaB transcription factor activity
  + 7 more...
.ubiquitin protein ligase activity
.protein homodimerization activity
.ubiquitin protein ligase binding
  + 5 more...
.perinuclear region of cytoplasm
.aggresome
.cytosol
  + 2 more...
5 EBI-748391,EBI-719493 TRIM27  
  .negative regulation of viral release from host cell
.negative regulation of interleukin-2 secretion
.negative regulation of calcium ion import
  + 17 more...
.metal ion binding
.ligase activity
.zinc ion binding
  + 4 more...
.nuclear membrane
.PML body
.membrane
  + 6 more...
6 EBI-748391,EBI-10172150 KRTAP10-5  
  .N/A .identical protein binding .keratin filament
7 EBI-748391,EBI-10172290 KRTAP10-7  
  .N/A .identical protein binding .keratin filament
8 EBI-748391,EBI-10171774 KRTAP10-8  
  .N/A .N/A .keratin filament
9 EBI-748391,EBI-10172052 KRTAP10-9  
  .N/A .N/A .keratin filament
10 EBI-748391,EBI-1181367 CDR2  
  .N/A .N/A .cytoplasm
11 EBI-748391,EBI-717810 AES  
  .positive regulation of anoikis
.negative regulation of canonical Wnt signaling pathway
.response to interleukin-1
  + 12 more...
.transcription corepressor activity .nucleus
12 EBI-748391,EBI-618309 GOLGA2  
  .negative regulation of protein binding
.mitotic cell cycle
.syntaxin binding
.protein kinase binding
.Golgi cisterna membrane
.ER to Golgi transport vesicle
.cis-Golgi network
  + 4 more...
13 EBI-748391,EBI-6509505 INCA1  
  .positive regulation of apoptotic signaling pathway
.negative regulation of cyclin-dependent protein serine/threonine kinase activity
.negative regulation of cell proliferation
.cyclin binding
.cyclin-dependent protein serine/threonine kinase inhibitor activity
.cytoplasm
.nucleus
14 EBI-748391,EBI-2340269 MKRN3  
  .protein ubiquitination .ligase activity
.zinc ion binding
.ribonucleoprotein complex
15 EBI-748391,EBI-359224 TRAF1  
  .regulation of extrinsic apoptotic signaling pathway
.positive regulation of NF-kappaB transcription factor activity
.signal transduction
  + 2 more...
.thioesterase binding
.ubiquitin protein ligase binding
.zinc ion binding
.tumor necrosis factor receptor binding
.cytoplasm
16 EBI-748391,EBI-745305 IKZF1  
  .retina development in camera-type eye
.positive regulation of NK T cell differentiation
.Peyer's patch development
  + 17 more...
.metal ion binding
.sequence-specific DNA binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.protein complex
.cytoplasm
.pericentric heterochromatin
.nucleus
17 EBI-748391,EBI-948001 KRT31  
  .epidermis development .structural constituent of cytoskeleton .extracellular exosome
.intermediate filament
.extracellular space
18 EBI-748391,EBI-8641936 NAB2  
  .regulation of epidermis development
.myelination
.negative regulation of transcription from RNA polymerase III promoter
  + 5 more...
.transcription corepressor activity .nucleus
19 EBI-748391,EBI-746004 UBXN11  
  .proteasome-mediated ubiquitin-dependent protein catabolic process .ubiquitin binding .cytoskeleton
.cytoplasm
20 EBI-748391,EBI-1105124 PDE4DIP  
  .cellular protein complex assembly .enzyme binding .myofibril
.centrosome
.Golgi apparatus
  + 2 more...
21 EBI-748391,EBI-726876 RINT1  
  .regulation of signal transduction involved in mitotic G2 DNA damage checkpoint
.regulation of ER to Golgi vesicle-mediated transport
.Golgi vesicle transport
  + 2 more...
.N/A .endoplasmic reticulum membrane
.endoplasmic reticulum
22 EBI-748391,EBI-945833 NOTCH2NL  
  .cell differentiation
.multicellular organismal development
.Notch signaling pathway
.calcium ion binding .cytoplasm
.extracellular region
23 EBI-748391,EBI-6872807 SYCE1  
  .cell division
.synaptonemal complex assembly
.N/A .central element
24 EBI-748391,EBI-741724 SPERT  
  .N/A .N/A .cytoplasmic membrane-bounded vesicle
25 EBI-748391,EBI-302345 PNMA1  
  .positive regulation of apoptotic process
.inflammatory response to antigenic stimulus
.N/A .focal adhesion
.cytoplasm
.nucleolus
26 EBI-748391,EBI-2548751 MIPOL1  
  .N/A .N/A .nucleus
27 EBI-748391,EBI-1050213 RPGRIP1  
  .retina development in camera-type eye
.response to stimulus
.eye photoreceptor cell development
.visual perception
.N/A .photoreceptor connecting cilium
.axoneme
28 EBI-748391,EBI-741037 LZTS2  
  .negative regulation of protein localization to nucleus
.negative regulation of canonical Wnt signaling pathway
.spindle midzone assembly
  + 7 more...
.N/A .midbody
.microtubule
.centrosome
.cytoplasm
29 EBI-748391,EBI-2130429 TRIM54  
  .cell differentiation
.multicellular organismal development
.signal transduction
  + 2 more...
.zinc ion binding
.signal transducer activity
.Z disc
.microtubule associated complex
.microtubule
30 EBI-748391,EBI-744115 CEP44  
  .N/A .N/A .midbody
.centrosome
.cytoplasm
.spindle pole
31 EBI-748391,EBI-2548012 BLZF1  
  .Golgi to plasma membrane protein transport
.cell proliferation
.Golgi organization
  + 3 more...
.ubiquitin protein ligase binding
.enzyme binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.Golgi lumen
.cytoplasm
.nucleoplasm
  + 2 more...
32 EBI-748391,EBI-740641 HMG20A  
  .negative regulation of neuron differentiation
.regulation of transcription, DNA-templated
.transcription, DNA-templated
  + 3 more...
.sequence-specific DNA binding transcription factor activity
.chromatin binding
.DNA binding
.nucleus
33 EBI-748391,EBI-10172526 MID2  
  .negative regulation of viral release from host cell
.positive regulation of NF-kappaB transcription factor activity
.positive regulation of sequence-specific DNA binding transcription factor activity
  + 6 more...
.phosphoprotein binding
.protein heterodimerization activity
.protein homodimerization activity
  + 3 more...
.extracellular exosome
.microtubule
.cytoplasm
34 EBI-748391,EBI-302355 PNMA2  
  .positive regulation of apoptotic process .N/A .nucleolus
35 EBI-748391,EBI-2212028 SSX2IP  
  .regulation of cell motility
.centrosome organization
.cilium assembly
  + 3 more...
.N/A .protein complex
.ciliary basal body
.centriolar satellite
  + 3 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland30
ascites150
blood32
bone139
bone marrow41
brain18
cervix61
connective tissue13
embryonic tissue28
esophagus49
eye81
heart22
intestine25
kidney42
liver29
lung62
lymph node33
mammary gland59
mouth15
muscle28
ovary29
pancreas9
pharynx122
placenta14
prostate10
skin47
stomach52
testis9
uterus12
Health State
TissuesTPM*
normal27
breast (mammary gland) tumor32
cervical tumor86
chondrosarcoma48
colorectal tumor35
esophageal tumor57
gastrointestinal tumor67
germ cell tumor26
glioma74
head and neck tumor7
kidney tumor29
leukemia21
liver tumor10
lung tumor68
lymphoma13
ovarian tumor39
pancreatic tumor19
primitive neuroectodermal tumor of the CNS15
retinoblastoma21
skin tumor71
soft tissue/muscle tissue tumor15
uterine tumor11
Developmental Stage
TissuesTPM*
adult39
embryoid body42
fetus26
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue22.3
adrenal gland22.7
appendix37.5
bone marrow34.6
cerebral cortex23.8
colon23.6
duodenum24.8
esophagus24.2
gallbladder23.7
heart muscle20.6
kidney21.3
liver11.1
lung26.6
lymph node48.4
ovary24
pancreas6.5
placenta26.2
prostate25.2
salivary gland20.4
skin30.9
small intestine24.1
spleen38.9
stomach21.3
testis20.1
thyroid gland21.4
urinary bladder30.5
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*608095, gene) Sodium channel modifier 1; SCNM1OMIM


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