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> Protein (NX_Q9BX66)
Protein (NX_Q9BX66)
Protein
Gene SymbolSORBS1 to neXtProt (NX_Q9BX66)
DescriptionSorbin and SH3 domain-containing protein 1
Chromosome10
Location10q24.1 (97071528 ~ 97321171) to Ensembl
Sequene Features : Isoforms 12, Variants 178, PTMs 22 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of establishment of protein localization to plasma membrane
.focal adhesion assembly
.positive regulation of lipid biosynthetic process
  + 9 more...
.cytoskeletal protein binding
.insulin receptor binding
.SH3/SH2 adaptor activity
.actin binding
.membrane raft
.nuclear matrix
.focal adhesion
  + 10 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
12 178 22
2014-09-19protein level
12 140 22
2014-05-27protein level
12 140 22
2014-02-25protein level
12 138 22
2013-12-09protein level
12 104 22
2013-11-01protein level
12 99 22
2013-09-12protein level
12 99 23
2013-08-17protein level
12 93 23
2013-07-15protein level
12 72 23
2013-06-11protein level
12 72 23
2013-02-12protein level
12 43 223
2012-12-20protein level
12 45 223
2012-10-30protein level
12 49 223
2012-10-07protein level
12 49 19
2012-08-24protein level
12 37 19
2012-07-28protein level
12 37 19
2012-06-08protein level
12 29 19
2012-05-07protein level
12 29 19
2012-04-10protein level
12 29 19
2012-01-13protein level
12 29 19
2011-12-20protein level
12 29 19
2011-11-11protein level
12 29 17
2011-08-23protein level
12 29 15
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9BX66-1
0 59 1 142425.3187
NX_Q9BX66-10
0 38 1 90162.9061
NX_Q9BX66-11
1 58 1 139315.014
NX_Q9BX66-12
28 40 1 143652.5347
NX_Q9BX66-2
5 50 1 127197.5481
NX_Q9BX66-3
2 44 1 101019.6634
NX_Q9BX66-4
0 34 1 76549.043
NX_Q9BX66-5
1 47 1 111721.9557
NX_Q9BX66-6
1 41 1 94977.388
NX_Q9BX66-7
0 29 0 68703.1637
NX_Q9BX66-8
0 41 1 90999.2763
NX_Q9BX66-9
0 39 1 87145.7409
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-433642,EBI-708350 ATXN7  
  .positive regulation of transcription from RNA polymerase II promoter
.negative regulation of insulin-like growth factor receptor signaling pathway
.negative regulation of phosphorylation
  + 6 more...
.chromatin binding .nuclear matrix
.microtubule cytoskeleton
.cytoplasm
  + 3 more...
2 EBI-433642,EBI-1384248 INPPL1  
  .ruffle assembly
.phosphatidylinositol dephosphorylation
.small molecule metabolic process
  + 13 more...
.SH2 domain binding
.hydrolase activity
.filopodium
.lamellipodium
.plasma membrane
  + 4 more...
3 EBI-433642,EBI-375543 ABL1  
  .regulation of response to DNA damage stimulus
.negative regulation of cellular senescence
.negative regulation of endothelial cell apoptotic process
  + 73 more...
.proline-rich region binding
.mitogen-activated protein kinase binding
.manganese ion binding
  + 12 more...
.perinuclear region of cytoplasm
.nuclear membrane
.cell leading edge
  + 8 more...
4 EBI-433642,EBI-466029 HTT  
  .negative regulation of extrinsic apoptotic signaling pathway
.iron ion homeostasis
.L-glutamate import
  + 38 more...
.diazepam binding
.beta-tubulin binding
.dynein intermediate chain binding
  + 6 more...
.protein complex
.cytoplasmic vesicle membrane
.dendrite
  + 11 more...
5 EBI-433642,EBI-1045887 PAK2  
  .negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis
.positive regulation of extrinsic apoptotic signaling pathway
.positive regulation of protein tyrosine kinase activity
  + 30 more...
.Rac GTPase binding
.identical protein binding
.protein tyrosine kinase activator activity
  + 4 more...
.perinuclear region of cytoplasm
.plasma membrane
.cytosol
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue854
bone13
brain115
connective tissue6
ear310
embryonic tissue32
eye33
heart201
intestine94
kidney18
larynx85
liver19
lung14
mammary gland39
mouth45
muscle94
nerve321
ovary19
pancreas9
parathyroid97
placenta70
prostate153
skin33
spleen18
stomach198
testis43
trachea173
uterus137
vascular154
Health State
TissuesTPM*
normal81
chondrosarcoma12
colorectal tumor124
gastrointestinal tumor16
germ cell tumor7
glioma65
head and neck tumor37
kidney tumor29
liver tumor20
non-neoplasia41
ovarian tumor26
pancreatic tumor9
prostate cancer38
skin tumor7
uterine tumor11
Developmental Stage
TissuesTPM*
adult79
embryoid body28
blastocyst48
fetus100
infant42
juvenile71
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue187.1
adrenal gland15.2
appendix42.4
bone marrow2.1
cerebral cortex46.6
colon43.4
duodenum18.9
esophagus123.9
gallbladder74.6
heart muscle180.1
kidney10.8
liver20.8
lung19.1
lymph node2.1
ovary8.3
pancreas9.2
placenta24
prostate85.7
salivary gland14.6
skin5.1
small intestine22.8
spleen5.8
stomach19.2
testis13.2
thyroid gland5.9
urinary bladder99.6
Tissues
TissuesExpression level
adrenal glandMedium
appendixHigh
bone marrowLow
breastMedium
bronchusMedium
cerebellumMedium
cerebral cortexMedium
cervix, uterineMedium
colonHigh
duodenumMedium
endometrium 1Low
endometrium 2Low
epididymisMedium
esophagusMedium
fallopian tubeMedium
gallbladderMedium
heart muscleHigh
hippocampusMedium
kidneyMedium
lateral ventricleMedium
liverMedium
lungMedium
nasopharynxMedium
oral mucosaLow
ovaryMedium
pancreasMedium
parathyroid glandHigh
placentaMedium
prostateLow
rectumHigh
salivary glandMedium
seminal vesicleLow
skeletal muscleLow
skin 1Medium
skin 2Medium
small intestineMedium
smooth muscleLow
soft tissue 1Low
stomach 1High
stomach 2High
testisMedium
thyroid glandMedium
tonsilLow
urinary bladderMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*605264, gene) Sorbin and sh3-domains containing 1; SORBS1OMIM


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