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> Protein (NX_Q9BXH1)
Protein (NX_Q9BXH1)
Protein
Gene SymbolBBC3 to neXtProt (NX_Q9BXH1)
DescriptionBcl-2-binding component 3
Chromosome19
Location19q13.32 (47724081 ~ 47736023) to Ensembl
Sequene Features : Isoforms 2, Variants 15, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of cysteine-type endopeptidase activity
.positive regulation of IRE1-mediated unfolded protein response
  + 21 more...
.N/A .cytosol
.mitochondrial outer membrane
.mitochondrion
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 15 1
2014-09-19protein level
2 12 1
2014-05-27protein level
2 12 1
2014-02-25protein level
2 12 1
2013-12-09protein level
2 10 1
2013-11-01protein level
2 10 1
2013-09-12protein level
2 10 1
2013-08-17protein level
2 10 1
2013-07-15protein level
2 10 1
2013-06-11protein level
2 10 1
2013-02-12protein level
2 6 0
2012-12-20protein level
2 4 0
2012-10-30protein level
2 6 0
2012-10-07protein level
2 6 0
2012-08-24protein level
2 4 0
2012-07-28protein level
2 4 0
2012-06-08protein level
2 4 0
2012-05-07protein level
2 4 0
2012-04-10protein level
2 4 0
2012-01-13protein level
2 1 0
2011-12-20protein level
2 1 0
2011-11-11protein level
2 1 0
2011-08-23protein level
2 1 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9BXH1-1
4 3 0 20519.437
NX_Q9BXH1-2
1 3 1 14450.1046
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-519884,EBI-77694 BCL2  
  .positive regulation of intrinsic apoptotic signaling pathway
.negative regulation of intrinsic apoptotic signaling pathway
.negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
  + 111 more...
.BH3 domain binding
.protein heterodimerization activity
.sequence-specific DNA binding
  + 6 more...
.pore complex
.myelin sheath
.nuclear membrane
  + 8 more...
2 EBI-519884,EBI-287195 BCL2L1  
  .positive regulation of intrinsic apoptotic signaling pathway
.negative regulation of intrinsic apoptotic signaling pathway
.negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
  + 42 more...
.BH3 domain binding
.protein heterodimerization activity
.protein homodimerization activity
  + 2 more...
.Bcl-2 family protein complex
.nuclear membrane
.synaptic vesicle membrane
  + 11 more...
3 EBI-519884,EBI-1003422 MCL1  
  .negative regulation of intrinsic apoptotic signaling pathway
.negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
.regulation of response to DNA damage stimulus
  + 10 more...
.BH3 domain binding
.protein heterodimerization activity
.protein homodimerization activity
.protein channel activity
.Bcl-2 family protein complex
.integral component of membrane
.membrane
  + 7 more...
4 EBI-519884,EBI-707714 BCL2L2  
  .negative regulation of intrinsic apoptotic signaling pathway
.extrinsic apoptotic signaling pathway in absence of ligand
.Sertoli cell proliferation
  + 3 more...
.protein heterodimerization activity
.protein homodimerization activity
.extracellular exosome
.cytosol
.mitochondrial outer membrane
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites25
bone13
cervix20
connective tissue6
eye19
intestine30
kidney4
larynx85
lung5
mammary gland6
muscle9
ovary29
placenta7
prostate5
skin9
stomach10
testis2
Health State
TissuesTPM*
normal3
breast (mammary gland) tumor10
cervical tumor28
chondrosarcoma12
colorectal tumor35
gastrointestinal tumor25
germ cell tumor18
head and neck tumor14
kidney tumor14
lymphoma27
ovarian tumor13
primitive neuroectodermal tumor of the CNS15
prostate cancer9
retinoblastoma21
soft tissue/muscle tissue tumor7
Developmental Stage
TissuesTPM*
adult6
fetus3
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue1.7
adrenal gland1.6
appendix2.8
bone marrow4.4
cerebral cortex2.5
colon5.5
duodenum2.7
gallbladder2.4
heart muscle1.3
kidney1.4
liver1.5
lung3.6
lymph node2.9
ovary1.7
pancreas2.9
placenta2.2
prostate2.2
salivary gland2.6
skin4.5
small intestine2.6
spleen3.3
stomach4
testis1.7
urinary bladder2.4
Tissues
TissuesExpression level
adrenal glandLow
appendixLow
bone marrowMedium
breastHigh
bronchusHigh
cerebellumHigh
cerebral cortexLow
cervix, uterineHigh
colonHigh
duodenumMedium
endometrium 1Medium
endometrium 2Medium
epididymisMedium
esophagusMedium
fallopian tubeMedium
gallbladderMedium
heart muscleMedium
hippocampusLow
lungHigh
lymph nodeMedium
nasopharynxMedium
oral mucosaMedium
ovaryMedium
pancreasHigh
placentaLow
rectumHigh
salivary glandMedium
skeletal muscleMedium
skin 1Medium
skin 2High
small intestineMedium
smooth muscleLow
soft tissue 1Medium
soft tissue 2Medium
stomach 1Low
testisMedium
thyroid glandMedium
tonsilMedium
vaginaHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*605854, gene) Bcl2-binding component 3; BBC3OMIM


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