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> Protein (NX_Q9BXM0)
Protein (NX_Q9BXM0)
Protein
Gene SymbolPRX to neXtProt (NX_Q9BXM0)
DescriptionPeriaxin
Chromosome19
Location19q13.2 (40899675 ~ 40919273) to Ensembl
Sequene Features : Isoforms 3, Variants 211, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.axon ensheathment .N/A .plasma membrane
.cytoplasm
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 211 0
2014-09-19protein level
3 158 0
2014-05-27protein level
3 158 1
2014-02-25protein level
3 157 1
2013-12-09protein level
3 118 1
2013-11-01protein level
3 116 1
2013-09-12protein level
3 116 3
2013-08-17protein level
3 116 3
2013-07-15protein level
3 89 3
2013-06-11protein level
3 89 3
2013-02-12protein level
3 53 8
2012-12-20protein level
3 51 6
2012-10-30protein level
3 63 6
2012-10-07protein level
3 63 3
2012-08-24protein level
3 56 3
2012-07-28protein level
3 54 3
2012-06-08protein level
3 54 3
2012-05-07protein level
3 54 3
2012-04-10protein level
3 54 3
2012-01-13protein level
3 30 3
2011-12-20protein level
3 30 3
2011-11-11protein level
3 30 3
2011-08-23protein level
3 30 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9BXM0-1
1 64 0 154806.7871
NX_Q9BXM0-2
1 4 0 15921.2992
NX_Q9BXM0-3
0 60 0 139524.6712
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1753064,EBI-389883 NCK1  
  .negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
.negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
.negative regulation of PERK-mediated unfolded protein response
  + 23 more...
.eukaryotic initiation factor eIF2 binding
.receptor tyrosine kinase binding
.protein binding, bridging
  + 5 more...
.vesicle membrane
.cell-cell junction
.plasma membrane
  + 6 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
brain8
embryonic tissue14
eye23
intestine12
muscle9
nerve579
prostate5
thymus12
uterus4
Health State
TissuesTPM*
normal10
germ cell tumor11
non-neoplasia10
soft tissue/muscle tissue tumor7
Developmental Stage
TissuesTPM*
adult7
blastocyst32
juvenile125
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue2.7
adrenal gland3.2
bone marrow1
cerebral cortex1.7
colon1
duodenum1.2
esophagus1.6
gallbladder2.3
heart muscle1.9
kidney4.3
lung25.1
lymph node1.2
ovary5.3
pancreas2
placenta4.1
prostate3
salivary gland2.5
skin1.6
small intestine1
spleen1.6
stomach1.7
testis1.9
thyroid gland5.7
urinary bladder1.6
Tissues
TissuesExpression level
breastMedium
cerebral cortexHigh
colonMedium
kidneyHigh
soft tissue 2Medium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#145900, phenotype) Hypertrophic neuropathy of dejerine-sottasOMIM
2(*605725, gene) Periaxin; PRXOMIM
3(#614895, phenotype) Charcot-marie-tooth disease, demyelinating, type 4f; CMT4FOMIM


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