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> Protein (NX_Q9BXM7)
Protein (NX_Q9BXM7)
Protein
Gene SymbolPINK1 to neXtProt (NX_Q9BXM7)
DescriptionSerine/threonine-protein kinase PINK1, mitochondrial
Chromosome1
Location1p36.12 (20959948 ~ 20978004) to Ensembl
Sequene Features : Isoforms 2, Variants 129, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of ATP biosynthetic process
.negative regulation of reactive oxygen species metabolic process
.regulation of reactive oxygen species metabolic process
  + 58 more...
.C3HC4-type RING finger domain binding
.protein kinase B binding
.ubiquitin protein ligase binding
  + 7 more...
.astrocyte projection
.Lewy body
.perinuclear region of cytoplasm
  + 13 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 129 2
2014-09-19protein level
2 113 2
2014-05-27protein level
2 113 2
2014-02-25protein level
2 112 2
2013-12-09protein level
2 98 2
2013-11-01protein level
2 97 2
2013-09-12protein level
2 97 2
2013-08-17protein level
2 97 2
2013-07-15protein level
2 84 2
2013-06-11protein level
2 84 2
2013-02-12protein level
2 77 3
2012-12-20protein level
2 77 3
2012-10-30protein level
2 85 3
2012-10-07protein level
2 85 0
2012-08-24protein level
2 85 0
2012-07-28protein level
2 85 0
2012-06-08protein level
2 87 0
2012-05-07protein level
2 86 0
2012-04-10protein level
2 86 0
2012-01-13protein level
2 79 0
2011-12-20protein level
2 79 0
2011-11-11protein level
2 79 0
2011-08-23protein level
2 79 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9BXM7-1
18 9 0 62728.7165
NX_Q9BXM7-2
1 9 0 30084.3018
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-2846068,EBI-716346 PARK2  
  .negative regulation of reactive oxygen species metabolic process
.regulation of reactive oxygen species metabolic process
.negative regulation of spontaneous neurotransmitter secretion
  + 78 more...
.F-box domain binding
.ubiquitin-specific protease binding
.cullin family protein binding
  + 21 more...
.Parkin-FBXW7-Cul1 ubiquitin ligase complex
.Lewy body
.perinuclear region of cytoplasm
  + 9 more...
2 EBI-2846068,EBI-923794 EED  
  .positive regulation of histone H3-K27 methylation
.negative regulation of transcription, DNA-templated
.negative regulation of gene expression, epigenetic
  + 5 more...
.identical protein binding
.histone methyltransferase activity
.chromatin binding
.pronucleus
.ESC/E(Z) complex
.cytoplasm
  + 4 more...
3 EBI-2846068,EBI-1396430 RHOT1  
  .mitochondrial outer membrane permeabilization
.regulation of small GTPase mediated signal transduction
.mitochondrion transport along microtubule
  + 2 more...
.GTP binding
.calcium ion binding
.GTPase activity
.integral component of mitochondrial outer membrane
.membrane
.plasma membrane
  + 2 more...
4 EBI-2846068,EBI-3942425 SOCS4  
  .negative regulation of JAK-STAT cascade
.regulation of growth
.intracellular signal transduction
  + 4 more...
.protein kinase inhibitor activity .cytoplasm
5 EBI-2846068,EBI-373144 MAP1LC3B  
  .regulation of mitochondrion degradation
.membrane fusion
.nucleophagy
  + 3 more...
.microtubule binding .cytoplasmic vesicle
.organelle membrane
.extrinsic component of membrane
  + 9 more...
6 EBI-2846068,EBI-1161222 FBXO7  
  .negative regulation of G1/S transition of mitotic cell cycle
.negative regulation of cyclin-dependent protein serine/threonine kinase activity
.negative regulation of lymphocyte differentiation
  + 5 more...
.ubiquitin-protein transferase activity .protein complex
.cytosol
.mitochondrion
  + 3 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland91
ascites25
bladder33
blood32
bone69
bone marrow20
brain97
cervix20
connective tissue93
ear124
embryonic tissue14
eye124
heart100
intestine34
kidney75
liver43
lung80
lymph node11
mammary gland6
mouth136
muscle141
nerve514
ovary19
pancreas84
parathyroid97
pharynx24
pituitary gland242
placenta105
prostate58
salivary gland296
skin104
spleen18
stomach10
testis319
thymus12
thyroid128
trachea38
uterus73
vascular19
Health State
TissuesTPM*
normal84
adrenal tumor158
breast (mammary gland) tumor10
cervical tumor28
chondrosarcoma156
colorectal tumor44
gastrointestinal tumor25
germ cell tumor30
glioma139
head and neck tumor149
kidney tumor72
leukemia21
liver tumor41
lung tumor19
non-neoplasia93
pancreatic tumor76
primitive neuroectodermal tumor of the CNS55
prostate cancer38
retinoblastoma21
skin tumor39
soft tissue/muscle tissue tumor15
uterine tumor44
Developmental Stage
TissuesTPM*
adult85
embryoid body14
blastocyst32
fetus73
infant85
juvenile143
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue44.1
adrenal gland102.9
appendix17.6
bone marrow10.9
cerebral cortex96.5
colon40.3
duodenum31.2
esophagus56.9
gallbladder37.4
heart muscle118.8
kidney74.2
liver61.1
lung34.3
lymph node15.2
ovary33.6
pancreas27.6
placenta38.3
prostate41.5
salivary gland48.6
skin35
small intestine28.9
spleen23.3
stomach24.9
testis95.1
thyroid gland54.6
urinary bladder38.8
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#168600, phenotype) Parkinson disease, late-onset; PDOMIM
2(#605909, phenotype) Parkinson disease 6, autosomal recessive early-onset; PARK6OMIM
3(*608309, gene) Pten-induced putative kinase 1; PINK1OMIM


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