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> Protein (NX_Q9BXN2)
Protein (NX_Q9BXN2)
Protein
Gene SymbolCLEC7A to neXtProt (NX_Q9BXN2)
DescriptionC-type lectin domain family 7 member A
Chromosome12
Location12p13.2 (10269376 ~ 10282857) to Ensembl
Sequene Features : Isoforms 10, Variants 53, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.innate immune response
.defense response to protozoan
.T cell activation
  + 6 more...
.metal ion binding
.MHC protein binding
.carbohydrate binding
.signaling pattern recognition receptor activity
.integral component of membrane
.plasma membrane
.cytoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
10 53 4
2014-09-19protein level
10 39 4
2014-05-27protein level
10 35 4
2014-02-25protein level
10 34 4
2013-12-09protein level
10 29 4
2013-11-01protein level
10 27 4
2013-09-12protein level
10 27 4
2013-08-17protein level
10 27 4
2013-07-15protein level
9 17 4
2013-06-11protein level
9 17 4
2013-02-12protein level
9 12 32
2012-12-20protein level
9 13 32
2012-10-30protein level
9 13 32
2012-10-07protein level
9 13 6
2012-08-24protein level
9 9 6
2012-07-28protein level
9 9 6
2012-06-08protein level
9 10 6
2012-05-07protein level
9 10 6
2012-04-10protein level
8 10 6
2012-01-13protein level
8 8 6
2011-12-20protein level
8 8 6
2011-11-11protein level
8 8 6
2011-08-23protein level
8 8 6
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9BXN2-1
0 11 0 27609.4922
NX_Q9BXN2-10
5 2 0 13129.6966
NX_Q9BXN2-2
0 8 0 22548.025
NX_Q9BXN2-3
0 9 0 21051.3914
NX_Q9BXN2-4
2 8 0 21116.521
NX_Q9BXN2-5
1 6 0 19205.0987
NX_Q9BXN2-6
1 5 0 14777.1799
NX_Q9BXN2-7
0 6 0 15989.9242
NX_Q9BXN2-8
0 1 0 5160.4159
NX_Q9BXN2-9
1 2 0 8357.2846
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-3939278,EBI-849893 BNIP3L  
  .mitochondrial outer membrane permeabilization
.defense response to virus
.negative regulation of apoptotic process
  + 3 more...
.protein heterodimerization activity
.protein homodimerization activity
.identical protein binding
.lamin binding
.intrinsic component of membrane
.integral component of membrane
.endoplasmic reticulum
  + 3 more...
2 EBI-3939278,EBI-3906138 PTTG1IP  
  .multicellular organismal development
.protein import into nucleus
.receptor activity .extracellular exosome
.integral component of membrane
.membrane
  + 2 more...
3 EBI-3939278,EBI-993762 IL1RL1  
  .positive regulation of chemokine secretion
.positive regulation of inflammatory response
.negative regulation of I-kappaB kinase/NF-kappaB signaling
  + 7 more...
.receptor signaling protein activity
.interleukin-1 receptor activity
.cytokine receptor activity
.interleukin-33 receptor activity
.extracellular matrix
.integral component of membrane
.external side of plasma membrane
.extracellular region
4 EBI-3939278,EBI-749464 BNIP3  
  .intrinsic apoptotic signaling pathway in response to hypoxia
.toxin transport
.mitochondrial outer membrane permeabilization
  + 28 more...
.GTPase binding
.protein heterodimerization activity
.protein homodimerization activity
.identical protein binding
.mitochondrial membrane
.integral component of mitochondrial outer membrane
.dendrite
  + 7 more...
5 EBI-3939278,EBI-2903088 OCLN  
  .tight junction assembly
.S-adenosylmethionine metabolic process
.S-adenosylhomocysteine metabolic process
  + 5 more...
.protein domain specific binding
.thiopurine S-methyltransferase activity
.cytoplasmic vesicle
.endocytic vesicle
.cell junction
  + 7 more...
6 EBI-3939278,EBI-359761 KTN1  
  .small GTPase mediated signal transduction
.microtubule-based movement
.poly(A) RNA binding .integral component of membrane
.membrane
.integral component of plasma membrane
  + 2 more...
7 EBI-3939278,EBI-7131783 SYNE4  
  .establishment of epithelial cell apical/basal polarity .N/A .LINC complex
.integral component of nuclear outer membrane
8 EBI-3939278,EBI-10266796 JAGN1  
  .neutrophil migration
.defense response to fungus
.granulocyte colony-stimulating factor signaling pathway
  + 6 more...
.N/A .integral component of membrane
.endoplasmic reticulum membrane
.endoplasmic reticulum
9 EBI-3939278,EBI-8649725 TMEM79  
  .cornification
.establishment of skin barrier
.positive regulation of epidermis development
  + 4 more...
.N/A .trans-Golgi network membrane
.integral component of membrane
.lysosomal membrane
10 EBI-3939278,EBI-10303054 ADAM33  
  .proteolysis .zinc ion binding
.metalloendopeptidase activity
.integral component of membrane
11 EBI-3939278,EBI-741850 SMIM3  
  .N/A .N/A .integral component of membrane
12 EBI-3939278,EBI-10312990 TMPRSS4  
  .proteolysis .scavenger receptor activity
.serine-type endopeptidase activity
.integral component of membrane
13 EBI-3939278,EBI-10317425 NINJ2  
  .tissue regeneration
.nervous system development
.neuron cell-cell adhesion
.N/A .integral component of plasma membrane
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
bladder33
blood302
bone marrow41
brain18
intestine8
larynx85
lung2
mammary gland6
muscle18
placenta17
spleen149
thymus12
thyroid21
trachea38
vascular38
Health State
TissuesTPM*
normal22
bladder carcinoma56
breast (mammary gland) tumor10
head and neck tumor22
leukemia42
lymphoma27
non-neoplasia10
Developmental Stage
TissuesTPM*
adult11
neonate128
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue9.8
adrenal gland6.7
appendix64.9
bone marrow61.6
cerebral cortex4
colon8
duodenum7.9
esophagus9.1
gallbladder18.1
heart muscle3.1
kidney3.3
liver7.2
lung27.1
lymph node17.9
ovary3.6
pancreas1.6
placenta11.2
prostate3.7
salivary gland3.1
skin4.6
small intestine10.9
spleen34.1
stomach6
testis3.8
thyroid gland2.7
urinary bladder14.4
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*606264, gene) C-type lectin domain family 7, member a; CLEC7AOMIM
2(#613108, phenotype) Candidiasis, familial, 4; CANDF4OMIM
3(#614079, phenotype) Aspergillosis, susceptibility toOMIM


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