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> Protein (NX_Q9BY11)
Protein (NX_Q9BY11)
Protein
Gene SymbolPACSIN1 to neXtProt (NX_Q9BY11)
DescriptionProtein kinase C and casein kinase substrate in neurons protein 1
Chromosome6
Location6p21.31 (34433916 ~ 34503006) to Ensembl
Sequene Features : Isoforms 1, Variants 48, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of dendrite development
.membrane tubulation
.establishment of protein localization to plasma membrane
  + 7 more...
.cytoskeletal protein binding
.phospholipid binding
.perinuclear region of cytoplasm
.synapse
.axon terminus
  + 11 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 48 3
2014-09-19protein level
1 38 3
2014-05-27protein level
1 38 3
2014-02-25protein level
1 38 3
2013-12-09protein level
1 29 3
2013-11-01protein level
1 24 3
2013-09-12protein level
1 24 3
2013-08-17protein level
1 24 3
2013-07-15protein level
1 16 3
2013-06-11protein level
1 16 3
2013-02-12protein level
1 4 1
2012-12-20protein level
1 4 1
2012-10-30protein level
1 5 1
2012-10-07protein level
1 5 1
2012-08-24protein level
1 5 1
2012-07-28protein level
1 5 1
2012-06-08protein level
1 5 1
2012-05-07protein level
1 4 1
2012-04-10protein level
1 4 1
2012-01-13protein level
1 3 1
2011-12-20protein level
1 3 1
2011-11-11protein level
1 3 1
2011-08-23protein level
1 3 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9BY11-1
18 0 0 50933.6777
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-721769,EBI-466029 HTT  
  .negative regulation of extrinsic apoptotic signaling pathway
.iron ion homeostasis
.L-glutamate import
  + 38 more...
.diazepam binding
.beta-tubulin binding
.dynein intermediate chain binding
  + 6 more...
.protein complex
.cytoplasmic vesicle membrane
.dendrite
  + 11 more...
2 EBI-721769,EBI-495538 FASLG  
  .positive regulation of endothelial cell apoptotic process
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
.necroptotic signaling pathway
  + 30 more...
.receptor binding .extracellular exosome
.cytoplasmic membrane-bounded vesicle lumen
.perinuclear region of cytoplasm
  + 8 more...
3 EBI-721769,EBI-77926 PACSIN3  
  .membrane tubulation
.negative regulation of calcium ion transport
.positive regulation of membrane protein ectodomain proteolysis
  + 4 more...
.calcium channel inhibitor activity
.lipid binding
.cytoskeletal protein binding
.phospholipid binding
.extracellular exosome
.membrane-bounded vesicle
.membrane
  + 4 more...
4 EBI-721769,EBI-742503 PACSIN2  
  .membrane tubulation
.caveolin-mediated endocytosis
.caveola assembly
  + 5 more...
.phosphatidic acid binding
.identical protein binding
.cytoskeletal protein binding
.transporter activity
.extracellular exosome
.recycling endosome membrane
.intracellular membrane-bounded organelle
  + 12 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
brain51
embryonic tissue23
eye81
lung17
lymph22
lymph node22
nerve64
prostate10
tonsil58
uterus4
Health State
TissuesTPM*
normal24
glioma55
lung tumor9
lymphoma69
non-neoplasia51
prostate cancer19
retinoblastoma86
uterine tumor11
Developmental Stage
TissuesTPM*
adult22
blastocyst32
fetus10
infant85
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
appendix1.2
cerebral cortex70.9
heart muscle3
lymph node3.7
pancreas2.3
spleen1.6
Tissues
TissuesExpression level
cerebellumHigh
cerebral cortexHigh
colonMedium
hippocampusHigh
lateral ventricleHigh
lymph nodeMedium
tonsilMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*606512, gene) Protein kinase c and casein kinase substrate in neurons 1; PACSIN1OMIM


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