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> Protein (NX_Q9BYB0)
Protein (NX_Q9BYB0)
Protein
Gene SymbolSHANK3 to neXtProt (NX_Q9BYB0)
DescriptionSH3 and multiple ankyrin repeat domains protein 3
Chromosome22
Location22q13.33 (51112843 ~ 51171726) to Ensembl
Sequene Features : Isoforms 2, Variants 30, PTMs 10 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
.positive regulation of excitatory postsynaptic membrane potential
.regulation of long term synaptic depression
  + 25 more...
.scaffold protein binding
.identical protein binding
.ionotropic glutamate receptor binding
  + 4 more...
.neuronal postsynaptic density
.ciliary membrane
.postsynaptic membrane
  + 6 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 30 10
2014-09-19protein level
2 30 10
2014-02-25protein level
2 30 10
2013-12-09protein level
2 15 10
2013-11-01protein level
2 15 10
2012-07-28protein level
2 15 11
2012-06-08protein level
2 15 11
2012-05-07protein level
2 15 11
2012-04-10protein level
2 15 11
2012-01-13protein level
2 15 11
2011-12-20protein level
2 19 11
2011-11-11protein level
2 19 11
2011-08-23protein level
2 9 11
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9BYB0-1
7 63 2 184554.0226
NX_Q9BYB0-3
1 63 2 171045.8964
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1752330,EBI-389883 NCK1  
  .negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
.negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
.negative regulation of PERK-mediated unfolded protein response
  + 23 more...
.eukaryotic initiation factor eIF2 binding
.receptor tyrosine kinase binding
.protein binding, bridging
  + 5 more...
.vesicle membrane
.cell-cell junction
.plasma membrane
  + 6 more...
2 EBI-1752330,EBI-79387 PLCG1  
  .cellular response to epidermal growth factor stimulus
.positive regulation of release of sequestered calcium ion into cytosol
.leukocyte migration
  + 24 more...
.protein kinase binding
.calcium ion binding
.neurotrophin TRKA receptor binding
  + 3 more...
.cell projection
.lamellipodium
.COP9 signalosome
  + 5 more...
3 EBI-1752330,EBI-401755 GRB2  
  .positive regulation of reactive oxygen species metabolic process
.cellular response to ionizing radiation
.branching involved in labyrinthine layer morphogenesis
  + 25 more...
.ephrin receptor binding
.poly(A) RNA binding
.insulin receptor substrate binding
  + 6 more...
.Grb2-EGFR complex
.extracellular exosome
.vesicle membrane
  + 10 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
bone83
brain26
connective tissue33
embryonic tissue32
eye33
heart44
intestine21
kidney23
liver4
lung26
lymph node11
mammary gland6
mouth15
nerve64
ovary29
pancreas37
placenta10
spleen56
stomach20
testis11
thyroid21
uterus30
vascular19
Health State
TissuesTPM*
normal24
breast (mammary gland) tumor10
chondrosarcoma96
gastrointestinal tumor25
germ cell tumor7
glioma93
head and neck tumor14
kidney tumor14
liver tumor20
lung tumor19
non-neoplasia31
ovarian tumor26
pancreatic tumor19
primitive neuroectodermal tumor of the CNS39
retinoblastoma43
soft tissue/muscle tissue tumor39
uterine tumor22
Developmental Stage
TissuesTPM*
adult24
embryoid body14
blastocyst32
fetus46
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue27.2
adrenal gland2.3
appendix3
cerebral cortex9.6
colon2.1
duodenum2
esophagus2
gallbladder4.4
heart muscle5.3
kidney7.2
liver2.4
lung11.5
lymph node2.4
ovary1
pancreas1.3
placenta7.6
prostate3.6
salivary gland3.8
skin3.5
small intestine1.9
spleen41.2
stomach2
testis2
thyroid gland4.3
urinary bladder4.8
Tissues
TissuesExpression level
appendixLow
breastMedium
bronchusMedium
cerebellumHigh
cerebral cortexMedium
cervix, uterineLow
colonMedium
duodenumLow
endometrium 1Low
endometrium 2Low
epididymisMedium
fallopian tubeMedium
hippocampusHigh
kidneyMedium
lateral ventricleHigh
lungMedium
nasopharynxMedium
pancreasMedium
placentaMedium
salivary glandLow
small intestineLow
thyroid glandMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*606230, gene) Sh3 and multiple ankyrin repeat domains 3; SHANK3OMIM
2(#606232, phenotype) Chromosome 22q13.3 deletion syndromeOMIM
3(#613950, phenotype) Schizophrenia 15; SCZD15OMIM


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