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> Protein (NX_Q9BYG4)
Protein (NX_Q9BYG4)
Protein
Gene SymbolPARD6G to neXtProt (NX_Q9BYG4)
DescriptionPartitioning defective 6 homolog gamma
Chromosome18
Location18q23 (77915115 ~ 78005429) to Ensembl
Sequene Features : Isoforms 2, Variants 32, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.tight junction assembly
.cell division
.cell-cell junction organization
  + 2 more...
.N/A .protein complex
.tight junction
.plasma membrane
.cytosol
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 32 0
2014-09-19protein level
2 24 0
2014-05-27protein level
2 24 0
2014-02-25protein level
2 24 0
2013-12-09protein level
2 18 0
2013-11-01protein level
2 17 0
2013-09-12protein level
2 17 0
2013-08-17protein level
2 17 0
2013-07-15protein level
1 11 0
2013-06-11protein level
1 11 0
2013-02-12protein level
1 5 0
2012-12-20protein level
1 5 0
2012-10-30protein level
1 5 0
2012-10-07protein level
1 5 0
2012-08-24protein level
1 2 0
2012-07-28protein level
1 2 0
2012-06-08protein level
1 2 0
2012-05-07protein level
1 2 0
2012-04-10protein level
1 2 0
2012-01-13protein level
1 3 0
2011-12-20protein level
1 3 0
2011-11-11protein level
1 3 0
2011-08-23protein level
1 3 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9BYG4-1
11 3 2 40858.0537
NX_Q9BYG4-2
1 3 0 12235.1317
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-295417,EBI-286199 PRKCI  
  .positive regulation of endothelial cell apoptotic process
.positive regulation of establishment of protein localization to plasma membrane
.tight junction assembly
  + 25 more...
.metal ion binding
.phospholipid binding
.ATP binding
  + 3 more...
.extracellular exosome
.intercellular bridge
.protein complex
  + 11 more...
2 EBI-295417,EBI-81752 CDC42  
  .positive regulation of substrate adhesion-dependent cell spreading
.positive regulation of intracellular protein transport
.epithelial cell-cell adhesion
  + 61 more...
.identical protein binding
.apolipoprotein A-I receptor binding
.thioesterase binding
  + 3 more...
.mitotic spindle
.extracellular exosome
.spindle midzone
  + 17 more...
3 EBI-295417,EBI-413628 RAC1  
  .positive regulation of substrate adhesion-dependent cell spreading
.apoptotic signaling pathway
.ruffle assembly
  + 63 more...
.Rho GDP-dissociation inhibitor binding
.thioesterase binding
.enzyme binding
  + 2 more...
.extracellular exosome
.melanosome
.cytoplasmic ribonucleoprotein granule
  + 12 more...
4 EBI-295417,EBI-306940 YWHAH  
  .regulation of sodium ion transmembrane transporter activity
.positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
.intrinsic apoptotic signaling pathway
  + 16 more...
.protein heterodimerization activity
.ion channel binding
.glucocorticoid receptor binding
  + 4 more...
.extracellular exosome
.cytoplasmic vesicle membrane
.intercalated disc
  + 3 more...
5 EBI-295417,EBI-295351 PRKCZ  
  .positive regulation of interleukin-10 secretion
.positive regulation of interleukin-13 secretion
.positive regulation of interleukin-5 secretion
  + 38 more...
.metal ion binding
.insulin receptor substrate binding
.potassium channel regulator activity
  + 4 more...
.extracellular exosome
.perinuclear region of cytoplasm
.apical cortex
  + 17 more...
6 EBI-295417,EBI-516560 MARK2  
  .mitochondrion localization
.regulation of cytoskeleton organization
.regulation of axonogenesis
  + 11 more...
.tau-protein kinase activity
.poly(A) RNA binding
.protein kinase activator activity
  + 4 more...
.microtubule bundle
.basal cortex
.lateral plasma membrane
  + 5 more...
7 EBI-295417,EBI-81968 PARD3  
  .establishment of epithelial cell polarity
.tight junction assembly
.regulation of cellular localization
  + 18 more...
.phosphatidylinositol-3-phosphate binding
.phosphatidylinositol-3,4,5-trisphosphate binding
.phosphatidylinositol-4,5-bisphosphate binding
.apical part of cell
.axonal growth cone
.protein complex
  + 11 more...
8 EBI-295417,EBI-302319 MARK4  
  .positive regulation of programmed cell death
.nervous system development
.organelle organization
  + 3 more...
.tau-protein kinase activity
.ubiquitin binding
.gamma-tubulin binding
  + 3 more...
.neuron projection
.ciliary basal body
.microtubule cytoskeleton
  + 3 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
bone marrow20
brain10
connective tissue20
embryonic tissue9
eye4
heart33
intestine8
kidney23
liver4
lung11
mammary gland6
mouth15
ovary49
pancreas23
parathyroid48
placenta10
prostate5
skin37
stomach10
testis2
uterus4
Health State
TissuesTPM*
normal17
chondrosarcoma36
gastrointestinal tumor16
germ cell tumor15
glioma9
head and neck tumor7
kidney tumor14
leukemia21
ovarian tumor78
skin tumor7
Developmental Stage
TissuesTPM*
adult9
embryoid body14
fetus28
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue2.4
adrenal gland1.8
appendix1.2
cerebral cortex1.7
colon2.6
duodenum1.3
esophagus10.4
gallbladder3.2
heart muscle2
kidney5.5
liver1.9
lung2.5
lymph node2.1
ovary5
placenta3.8
prostate5.2
salivary gland2.4
skin26.3
small intestine2
spleen2.1
testis1.7
thyroid gland10
urinary bladder5
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*608976, gene) Partitioning-defective protein 6, c. elegans, homolog of, gamma; PARD6GOMIM


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