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> Protein (NX_Q9BYR5)
Protein (NX_Q9BYR5)
Protein
Gene SymbolKRTAP4-2 to neXtProt (NX_Q9BYR5)
DescriptionKeratin-associated protein 4-2
Chromosome17
Location17q21.2 (39333698 ~ 39334460) to Ensembl
Sequene Features : Isoforms 1, Variants 25, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.N/A .N/A .keratin filament
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 25 0
2014-09-19protein level
1 19 0
2014-05-27protein level
1 19 0
2014-02-25protein level
1 19 0
2013-12-09protein level
1 15 0
2013-11-01protein level
1 15 0
2013-09-12protein level
1 15 0
2013-08-17protein level
1 15 0
2013-07-15protein level
1 8 0
2013-06-11protein level
1 8 0
2013-02-12protein level
1 4 0
2012-12-20protein level
1 5 0
2012-10-30protein level
1 6 0
2012-10-07protein level
1 6 0
2012-08-24transcript level
1 6 0
2012-07-28transcript level
1 5 0
2012-06-08transcript level
1 5 0
2012-05-07transcript level
1 5 0
2012-04-10transcript level
1 5 0
2012-01-13transcript level
1 4 0
2011-12-20transcript level
1 4 0
2011-11-11transcript level
1 4 0
2011-08-23transcript level
1 4 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9BYR5-1
3 0 1 14450.1483
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-10172511,EBI-740019 PLSCR1  
  .positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity
.regulation of Fc receptor mediated stimulatory signaling pathway
.defense response to virus
  + 11 more...
.CD4 receptor binding
.enzyme binding
.phospholipid scramblase activity
  + 5 more...
.extracellular exosome
.membrane raft
.extracellular matrix
  + 7 more...
2 EBI-10172511,EBI-744471 ZBTB24  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.hematopoietic progenitor cell differentiation
.metal ion binding
.DNA binding
.nucleus
3 EBI-10172511,EBI-3866665 SPRY1  
  .negative regulation of ERK1 and ERK2 cascade
.bud elongation involved in lung branching
.negative regulation of neurotrophin TRK receptor signaling pathway
  + 10 more...
.N/A .plasma membrane
.cytosol
4 EBI-10172511,EBI-1053424 PRKAB2  
  .membrane organization
.regulation of protein kinase activity
.small molecule metabolic process
  + 13 more...
.identical protein binding .AMP-activated protein kinase complex
.cytosol
.nucleoplasm
5 EBI-10172511,EBI-374781 GLRX3  
  .cell redox homeostasis
.negative regulation of cardiac muscle hypertrophy
.regulation of the force of heart contraction
.iron-sulfur cluster binding
.metal ion binding
.poly(A) RNA binding
  + 2 more...
.extracellular exosome
.Z disc
.cell cortex
6 EBI-10172511,EBI-1052678 RGS20  
  .positive regulation of GTPase activity
.termination of G-protein coupled receptor signaling pathway
.regulation of G-protein coupled receptor protein signaling pathway
.GTPase activator activity .plasma membrane
.trans-Golgi network
.cytoplasm
.nucleus
7 EBI-10172511,EBI-742764 PDE9A  
  .cGMP-mediated signaling
.metabolic process
.blood coagulation
.signal transduction
.3',5'-cyclic-GMP phosphodiesterase activity
.metal ion binding
.3',5'-cyclic-nucleotide phosphodiesterase activity
.perinuclear region of cytoplasm
.perikaryon
.ruffle membrane
  + 3 more...
8 EBI-10172511,EBI-717634 ZNF20  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
9 EBI-10172511,EBI-3958099 KRTAP5-9  
  .epidermis development .N/A .keratin filament
10 EBI-10172511,EBI-745213 AQP1  
  .cation transmembrane transport
.maintenance of symbiont-containing vacuole by host
.ammonium transmembrane transport
  + 60 more...
.carbon dioxide transmembrane transporter activity
.nitric oxide transmembrane transporter activity
.transmembrane transporter activity
  + 8 more...
.extracellular exosome
.apical part of cell
.axon terminus
  + 12 more...
11 EBI-10172511,EBI-740446 OTX1  
  .diencephalon morphogenesis
.positive regulation of transcription from RNA polymerase II promoter
.inner ear morphogenesis
  + 3 more...
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.RNA polymerase II core promoter proximal region sequence-specific DNA binding
.nucleus
12 EBI-10172511,EBI-749311 HPCAL1  
  .signal transduction .calcium ion binding .extracellular exosome
13 EBI-10172511,EBI-740785 HOXA1  
  .cochlea morphogenesis
.cochlea development
.cellular response to retinoic acid
  + 24 more...
.sequence-specific DNA binding .nucleus
14 EBI-10172511,EBI-1181439 PRKAG1  
  .membrane organization
.protein heterooligomerization
.positive regulation of protein kinase activity
  + 12 more...
.ADP binding
.protein kinase binding
.AMP binding
  + 5 more...
.extracellular exosome
.AMP-activated protein kinase complex
.membrane
  + 2 more...
15 EBI-10172511,EBI-10172150 KRTAP10-5  
  .N/A .identical protein binding .keratin filament
16 EBI-10172511,EBI-10172290 KRTAP10-7  
  .N/A .identical protein binding .keratin filament
17 EBI-10172511,EBI-10171774 KRTAP10-8  
  .N/A .N/A .keratin filament
18 EBI-10172511,EBI-10172052 KRTAP10-9  
  .N/A .N/A .keratin filament
19 EBI-10172511,EBI-10217483 KRTAP10-11  
  .N/A .N/A .keratin filament
20 EBI-10172511,EBI-357793 PSMA6  
  .positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
.proteolysis involved in cellular protein catabolic process
  + 26 more...
.NF-kappaB binding
.purine ribonucleoside triphosphate binding
.threonine-type endopeptidase activity
  + 2 more...
.extracellular exosome
.sarcomere
.myofibril
  + 10 more...
21 EBI-10172511,EBI-10192698 CREB5  
  .adipose tissue development
.positive regulation of transcription, DNA-templated
.fat cell differentiation
.transcription from RNA polymerase II promoter
.metal ion binding
.sequence-specific DNA binding
.sequence-specific DNA binding transcription factor activity
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.extracellular exosome
.nucleus
22 EBI-10172511,EBI-3951628 TYRO3  
  .platelet aggregation
.neuron cellular homeostasis
.vagina development
  + 20 more...
.phosphatidylinositol 3-kinase binding
.ATP binding
.receptor signaling protein tyrosine kinase activity
  + 2 more...
.integral component of plasma membrane
.endoplasmic reticulum membrane
.nuclear envelope
.nucleus
23 EBI-10172511,EBI-714158 PIN1  
  .negative regulation of cell motility
.negative regulation of ERK1 and ERK2 cascade
.regulation of pathway-restricted SMAD protein phosphorylation
  + 11 more...
.phosphothreonine binding
.phosphoserine binding
.GTPase activating protein binding
  + 2 more...
.midbody
.nuclear speck
.cytoplasm
  + 2 more...
24 EBI-10172511,EBI-358049 BYSL  
  .cell proliferation
.female pregnancy
.cell adhesion
  + 2 more...
.poly(A) RNA binding .apical part of cell
.intracellular membrane-bounded organelle
.membrane
  + 3 more...
25 EBI-10172511,EBI-742828 LASP1  
  .positive regulation of signal transduction
.ion transport
.ion transmembrane transporter activity
.zinc ion binding
.SH3/SH2 adaptor activity
.extracellular exosome
.cortical actin cytoskeleton
.focal adhesion
26 EBI-10172511,EBI-2555767 ZNF124  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
27 EBI-10172511,EBI-10243533 -  
  .N/A .N/A .N/A
28 EBI-10172511,EBI-10245291 LCE3C  
  .keratinization .N/A .N/A
29 EBI-10172511,EBI-10245456 LCE3E  
  .keratinization .N/A .N/A
30 EBI-10172511,EBI-10245913 LCE1B  
  .keratinization .N/A .N/A
31 EBI-10172511,EBI-10246358 LCE4A  
  .keratinization .N/A .N/A
32 EBI-10172511,EBI-10246607 LCE2A  
  .keratinization .N/A .N/A
33 EBI-10172511,EBI-10247271 FAM74A6  
  .N/A .N/A .N/A
34 EBI-10172511,EBI-10250562 KRTAP5-6  
  .N/A .N/A .keratin filament
35 EBI-10172511,EBI-3957672 KRTAP26-1  
  .N/A .N/A .intermediate filament
36 EBI-10172511,EBI-10173507 ADAMTSL4  
  .cellular protein metabolic process
.post-translational protein modification
.positive regulation of apoptotic process
  + 4 more...
.metalloendopeptidase activity
.protease binding
.endoplasmic reticulum lumen
.interstitial matrix
37 EBI-10172511,EBI-727146 ATG9A  
  .innate immune response
.late nucleophagy
.piecemeal microautophagy of nucleus
  + 5 more...
.N/A .recycling endosome
.late endosome membrane
.cytoplasmic vesicle
  + 8 more...
38 EBI-10172511,EBI-945833 NOTCH2NL  
  .cell differentiation
.multicellular organismal development
.Notch signaling pathway
.calcium ion binding .cytoplasm
.extracellular region
39 EBI-10172511,EBI-3916986 SPATA24  
  .cell differentiation
.spermatogenesis
.multicellular organismal development
  + 2 more...
.DNA binding .cytoplasm
.nucleolus
.nucleoplasm
.nucleus
40 EBI-10172511,EBI-5235829 TRIM42  
  .N/A .zinc ion binding .intracellular
41 EBI-10172511,EBI-954696 TCEANC  
  .regulation of DNA-templated transcription, elongation
.regulation of transcription from RNA polymerase II promoter
.transcription, DNA-templated
.DNA binding .nucleus
42 EBI-10172511,EBI-740727 ZNF417  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
43 EBI-10172511,EBI-739832 LNX1  
  .protein homooligomerization
.protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.ligase activity
.zinc ion binding
.ubiquitin-protein transferase activity
.cytoplasm
44 EBI-10172511,EBI-367390 RASSF5  
  .regulation of protein localization to nucleus
.intracellular signal transduction
.positive regulation of protein ubiquitination
  + 2 more...
.metal ion binding .microtubule
.cytoplasm
.nucleus
45 EBI-10172511,EBI-448771 DOCK2  
  .positive regulation of phagocytosis
.regulation of defense response to virus by virus
.alpha-beta T cell proliferation
  + 12 more...
.T cell receptor binding
.Rac guanyl-nucleotide exchange factor activity
.extracellular exosome
.membrane
.endomembrane system
  + 2 more...
46 EBI-10172511,EBI-741158 WDYHV1  
  .cellular protein modification process .protein-N-terminal glutamine amidohydrolase activity .cytosol
.nucleus
47 EBI-10172511,EBI-746605 ZNF559  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
48 EBI-10172511,EBI-10185730 KRTAP9-4  
  .N/A .N/A .keratin filament
49 EBI-10172511,EBI-1044640 KRTAP9-2  
  .N/A .N/A .keratin filament
50 EBI-10172511,EBI-10303636 TINAGL1  
  .endosomal transport
.cell adhesion
.immune response
.polysaccharide binding
.cysteine-type peptidase activity
.extracellular matrix structural constituent
.scavenger receptor activity
.extracellular exosome
.cytoplasm
.extracellular space
.extracellular region
51 EBI-10172511,EBI-3918847 HSD3B7  
  .small molecule metabolic process
.bile acid metabolic process
.bile acid biosynthetic process
.cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase activity
.3-beta-hydroxy-delta5-steroid dehydrogenase activity
.integral component of membrane
.endoplasmic reticulum membrane
52 EBI-10172511,EBI-947551 CHRD  
  .positive regulation of cell adhesion
.negative regulation of osteoblast differentiation
.floor plate development
  + 9 more...
.cytokine binding
.heparin binding
.extracellular space
53 EBI-10172511,EBI-2826725 PVRL3  
  .retina morphogenesis in camera-type eye
.cell-cell junction organization
.adherens junction organization
  + 5 more...
.cell adhesion molecule binding
.protein homodimerization activity
.postsynaptic membrane
.apical junction complex
.integral component of membrane
  + 2 more...
54 EBI-10172511,EBI-10313866 C19orf66  
  .N/A .N/A .N/A
55 EBI-10172511,EBI-745520 ZNF581  
  .transcription from RNA polymerase II promoter
.regulation of transcription from RNA polymerase II promoter
.metal ion binding
.RNA polymerase II regulatory region sequence-specific DNA binding
.nucleus
56 EBI-10172511,EBI-1753397 DLGAP2  
  .neuron-neuron synaptic transmission .N/A .postsynaptic membrane
.cell junction
.postsynaptic density
.neurofilament
57 EBI-10172511,EBI-366978 NLK  
  .protein autophosphorylation
.intracellular signal transduction
.serine phosphorylation of STAT3 protein
  + 8 more...
.SH2 domain binding
.ubiquitin protein ligase binding
.transcription factor binding
  + 5 more...
.cytosol
.nucleoplasm
.nucleus
58 EBI-10172511,EBI-750394 SLC25A10  
  .sulfide oxidation, using sulfide:quinone oxidoreductase
.transmembrane transport
.small molecule metabolic process
  + 9 more...
.dicarboxylic acid transmembrane transporter activity .integral component of membrane
.mitochondrial inner membrane
.nucleus
59 EBI-10172511,EBI-713677 CRCT1  
  .N/A .N/A .N/A
60 EBI-10172511,EBI-1759386 SLC23A1  
  .transepithelial L-ascorbic acid transport
.dehydroascorbic acid transport
.small molecule metabolic process
  + 12 more...
.sodium-dependent L-ascorbate transmembrane transporter activity
.dehydroascorbic acid transporter activity
.L-ascorbic acid transporter activity
  + 3 more...
.extracellular exosome
.intracellular organelle
.apical plasma membrane
  + 6 more...
61 EBI-10172511,EBI-741528 CHIC2  
  .Golgi to plasma membrane transport .N/A .plasma membrane
.Golgi-associated vesicle
62 EBI-10172511,EBI-10187270 AMOTL2  
  .hippo signaling
.Wnt signaling pathway
.N/A .recycling endosome
.cytoplasmic vesicle
.apical plasma membrane
  + 2 more...


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