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> Protein (NX_Q9BYV2)
Protein (NX_Q9BYV2)
Protein
Gene SymbolTRIM54 to neXtProt (NX_Q9BYV2)
DescriptionTripartite motif-containing protein 54
Chromosome2
Location2p23.3 (27505260 ~ 27530307) to Ensembl
Sequene Features : Isoforms 2, Variants 54, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cell differentiation
.multicellular organismal development
.signal transduction
  + 2 more...
.zinc ion binding
.signal transducer activity
.Z disc
.microtubule associated complex
.microtubule
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 54 0
2014-09-19protein level
2 39 0
2014-05-27protein level
2 39 0
2014-02-25protein level
2 39 0
2013-12-09protein level
2 29 0
2013-11-01protein level
2 27 0
2013-09-12protein level
2 27 0
2013-08-17protein level
2 27 0
2013-07-15protein level
2 19 0
2013-06-11protein level
2 19 0
2013-02-12protein level
2 13 0
2012-12-20protein level
2 12 0
2012-10-30protein level
2 16 0
2012-10-07protein level
2 16 0
2012-08-24protein level
2 15 0
2012-07-28protein level
2 15 0
2012-06-08protein level
2 17 0
2012-05-07protein level
2 12 0
2012-04-10protein level
2 12 0
2012-01-13protein level
2 4 0
2011-12-20protein level
2 4 0
2011-11-11protein level
2 4 0
2011-08-23protein level
2 4 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9BYV2-1
1 16 2 40274.752
NX_Q9BYV2-2
3 16 2 44804.0062
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-2130429,EBI-5529694 STRA13  
  .kinetochore assembly
.cell division
.CENP-A containing nucleosome assembly
  + 6 more...
.DNA binding .FANCM-MHF complex
.Fanconi anaemia nuclear complex
.nucleoplasm
.condensed chromosome kinetochore
2 EBI-2130429,EBI-727004 SDCBP  
  .positive regulation of extracellular exosome assembly
.positive regulation of exosomal secretion
.ephrin receptor signaling pathway
  + 9 more...
.protein N-terminus binding
.protein heterodimerization activity
.syndecan binding
  + 4 more...
.blood microparticle
.extracellular exosome
.melanosome
  + 12 more...
3 EBI-2130429,EBI-3923013 SH2D1B  
  .positive regulation of innate immune response
.positive regulation of natural killer cell mediated immunity
.leukocyte activation involved in immune response
.protein binding, bridging .intracellular
4 EBI-2130429,EBI-398610 EIF4E2  
  .cytokine-mediated signaling pathway
.negative regulation of translation
.in utero embryonic development
.poly(A) RNA binding
.ubiquitin protein ligase binding
.translation factor activity, RNA binding
  + 2 more...
.mRNA cap binding complex
.cytosol
5 EBI-2130429,EBI-2513774 FARS2  
  .gene expression
.tRNA processing
.phenylalanyl-tRNA aminoacylation
.tRNA aminoacylation for protein translation
.ATP binding
.phenylalanine-tRNA ligase activity
.magnesium ion binding
.tRNA binding
.mitochondrial matrix
.mitochondrion
6 EBI-2130429,EBI-1783068 MBD3  
  .ATP-dependent chromatin remodeling
.histone acetylation
.tissue development
  + 5 more...
.methyl-CpG binding
.chromatin binding
.DNA binding
.protein complex
.NuRD complex
.cytoplasm
  + 3 more...
7 EBI-2130429,EBI-742362 DNAL4  
  .neurotrophin TRK receptor signaling pathway
.microtubule-based process
.motor activity .dynein complex
.cilium
.plasma membrane
  + 2 more...
8 EBI-2130429,EBI-702198 KRT6A  
  .activation of mitophagy in response to mitochondrial depolarization
.wound healing
.cell differentiation
  + 3 more...
.structural constituent of cytoskeleton .extracellular exosome
.keratin filament
.membrane
.nucleus
9 EBI-2130429,EBI-740907 KRT6B  
  .ectoderm development .structural constituent of cytoskeleton .extracellular exosome
.keratin filament
10 EBI-2130429,EBI-10177272 ZNF250  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.nucleus
11 EBI-2130429,EBI-739696 LMO2  
  .cellular response to thyroid hormone stimulus
.positive regulation of transcription from RNA polymerase II promoter
.negative regulation of erythrocyte differentiation
  + 3 more...
.E-box binding
.cofactor binding
.bHLH transcription factor binding
  + 7 more...
.transcription factor complex
.nucleus
12 EBI-2130429,EBI-355924 MCM7  
  .cellular response to epidermal growth factor stimulus
.response to drug
.regulation of phosphorylation
  + 8 more...
.ATP binding
.single-stranded DNA binding
.DNA helicase activity
.MCM complex
.membrane
.cytosol
  + 3 more...
13 EBI-2130429,EBI-375077 CDKN1A  
  .positive regulation of reactive oxygen species metabolic process
.regulation of DNA biosynthetic process
.negative regulation of G1/S transition of mitotic cell cycle
  + 44 more...
.metal ion binding
.ubiquitin protein ligase binding
.cyclin-dependent protein kinase activating kinase activity
.cyclin-dependent protein serine/threonine kinase inhibitor activity
.PCNA-p21 complex
.perinuclear region of cytoplasm
.intracellular membrane-bounded organelle
  + 4 more...
14 EBI-2130429,EBI-2564105 KRT6C  
  .intermediate filament cytoskeleton organization .structural molecule activity .extracellular exosome
.keratin filament
.intermediate filament
15 EBI-2130429,EBI-638194 ARFIP2  
  .regulation of Arp2/3 complex-mediated actin nucleation
.ruffle organization
.actin cytoskeleton organization
  + 3 more...
.phosphatidylinositol-4-phosphate binding
.Rac GTPase binding
.GTP-dependent protein binding
.GTP binding
.trans-Golgi network membrane
.cell cortex
.plasma membrane
  + 2 more...
16 EBI-2130429,EBI-746453 RAD23A  
  .positive regulation of viral genome replication
.proteasome-mediated ubiquitin-dependent protein catabolic process
.regulation of proteasomal ubiquitin-dependent protein catabolic process
  + 2 more...
.ubiquitin-specific protease binding
.polyubiquitin binding
.single-stranded DNA binding
.damaged DNA binding
.cytoplasm
.nucleoplasm
.proteasome complex
17 EBI-2130429,EBI-744104 GEM  
  .metaphase plate congression
.chromosome organization
.metabolic process
  + 5 more...
.GDP binding
.GTP binding
.GTPase activity
.magnesium ion binding
.mitotic spindle
.spindle midzone
.midbody
  + 2 more...
18 EBI-2130429,EBI-1048159 MFAP1  
  .extracellular matrix organization .poly(A) RNA binding .extracellular region
.microfibril
19 EBI-2130429,EBI-520375 CRADD  
  .positive regulation of apoptotic signaling pathway
.cellular response to mechanical stimulus
.extrinsic apoptotic signaling pathway via death domain receptors
  + 2 more...
.death domain binding
.protein binding, bridging
.protease binding
.cytoplasm
.nucleus
20 EBI-2130429,EBI-711925 ZBTB16  
  .positive regulation of cartilage development
.cartilage development
.positive regulation of NK T cell differentiation
  + 22 more...
.metal ion binding
.protein homodimerization activity
.identical protein binding
  + 4 more...
.transcriptional repressor complex
.nuclear speck
.PML body
  + 5 more...
21 EBI-2130429,EBI-748597 CCDC67  
  .multi-ciliated epithelial cell differentiation
.de novo centriole assembly
.cell projection organization
.N/A .deuterosome
.cytoplasm
22 EBI-2130429,EBI-746238 CDK18  
  .N/A .ATP binding
.cyclin-dependent protein serine/threonine kinase activity
.N/A
23 EBI-2130429,EBI-2339219 EHHADH  
  .fatty acid beta-oxidation
.internal protein amino acid acetylation
.coenzyme binding
.enzyme binding
.receptor binding
  + 3 more...
.cytosol
.peroxisome
.mitochondrion
24 EBI-2130429,EBI-602199 ARHGEF5  
  .positive regulation of podosome assembly
.regulation of GTPase activity
.intracellular signal transduction
  + 2 more...
.GTP binding
.Rho guanyl-nucleotide exchange factor activity
.N/A
25 EBI-2130429,EBI-358049 BYSL  
  .cell proliferation
.female pregnancy
.cell adhesion
  + 2 more...
.poly(A) RNA binding .apical part of cell
.intracellular membrane-bounded organelle
.membrane
  + 3 more...
26 EBI-2130429,EBI-742350 TCEB3  
  .positive regulation of viral transcription
.protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.viral process
  + 4 more...
.DNA binding .elongin complex
.integral component of membrane
.cytoplasm
  + 3 more...
27 EBI-2130429,EBI-710310 TCEA2  
  .positive regulation of transcription from RNA polymerase II promoter
.regulation of DNA-templated transcription, elongation
.DNA-templated transcription, elongation
.zinc ion binding
.DNA binding
.transcription elongation factor complex
.centrosome
.nucleoplasm
28 EBI-2130429,EBI-10236940 INPP5J  
  .phosphatidylinositol dephosphorylation
.small molecule metabolic process
.inositol phosphate metabolic process
  + 5 more...
.inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity
.inositol-1,4,5-trisphosphate 5-phosphatase activity
.phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity
.inositol-polyphosphate 5-phosphatase activity
.dendritic shaft
.growth cone
.plasma membrane
  + 3 more...
29 EBI-2130429,EBI-6426443 KLHL38  
  .N/A .N/A .N/A
30 EBI-2130429,EBI-719941 FAM161A  
  .response to stimulus
.cilium assembly
.visual perception
.N/A .ciliary basal body
.photoreceptor connecting cilium
.centrosome
.cytoplasm
31 EBI-2130429,EBI-739879 ALS2CR11  
  .N/A .N/A .N/A
32 EBI-2130429,EBI-6447954 TTC23  
  .N/A .N/A .N/A
33 EBI-2130429,EBI-2557469 PPP1R18  
  .N/A .N/A .cytoskeleton
.cytoplasm
34 EBI-2130429,EBI-10256202 RSRC2  
  .N/A .poly(A) RNA binding .N/A
35 EBI-2130429,EBI-6255981 EPM2AIP1  
  .positive regulation of glycogen (starch) synthase activity
.positive regulation of glycogen biosynthetic process
.response to insulin
.N/A .endoplasmic reticulum
.nucleus
36 EBI-2130429,EBI-10257016 ZNF572  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
37 EBI-2130429,EBI-6425928 GTF2IRD2  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.DNA binding .nucleus
38 EBI-2130429,EBI-740376 DTX2  
  .protein ubiquitination
.Notch signaling pathway
.ligase activity
.zinc ion binding
.nuclear membrane
.cytoplasm
.nucleoplasm
39 EBI-2130429,EBI-744506 FAM124A  
  .N/A .N/A .N/A
40 EBI-2130429,EBI-355471 CCDC28A  
  .N/A .N/A .N/A
41 EBI-2130429,EBI-10247802 CCDC146  
  .N/A .N/A .centriole
42 EBI-2130429,EBI-10181988 CEP57L1  
  .microtubule anchoring .N/A .microtubule
.microtubule organizing center
.cytoplasm
43 EBI-2130429,EBI-3439227 ZGPAT  
  .negative regulation of transcription, DNA-templated
.negative regulation of epidermal growth factor-activated receptor activity
.negative regulation of transcription from RNA polymerase II promoter
.metal ion binding
.sequence-specific DNA binding
.sequence-specific DNA binding transcription factor activity
  + 2 more...
.nucleus
44 EBI-2130429,EBI-739895 USHBP1  
  .N/A .PDZ domain binding .N/A
45 EBI-2130429,EBI-10220600 IQUB  
  .cilium morphogenesis
.smoothened signaling pathway
.N/A .motile cilium
.acrosomal vesicle
46 EBI-2130429,EBI-2838710 ADCY4  
  .cellular response to glucagon stimulus
.transmembrane transport
.neurotrophin TRK receptor signaling pathway
  + 16 more...
.metal ion binding
.ATP binding
.adenylate cyclase activity
.dendrite
.integral component of membrane
.membrane
  + 2 more...
47 EBI-2130429,EBI-747505 C1orf216  
  .N/A .N/A .N/A
48 EBI-2130429,EBI-740727 ZNF417  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
49 EBI-2130429,EBI-739832 LNX1  
  .protein homooligomerization
.protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.ligase activity
.zinc ion binding
.ubiquitin-protein transferase activity
.cytoplasm
50 EBI-2130429,EBI-10244131 FBF1  
  .establishment of epithelial cell polarity
.apical junction assembly
.cilium assembly
.organelle organization
.N/A .ciliary transition fiber
.cell junction
.cytosol
  + 3 more...
51 EBI-2130429,EBI-346417 ELMO1  
  .regulation of defense response to virus by virus
.vascular endothelial growth factor receptor signaling pathway
.innate immune response
  + 7 more...
.SH3 domain binding .membrane
.plasma membrane
.cytoskeleton
  + 2 more...
52 EBI-2130429,EBI-1051152 OSTF1  
  .signal transduction
.ossification
.N/A .extracellular exosome
.cytoplasm
.intracellular
53 EBI-2130429,EBI-455078 SMARCE1  
  .negative regulation of transcription, DNA-templated
.ATP-dependent chromatin remodeling
.metabolic process
  + 4 more...
.protein N-terminus binding
.ligand-dependent nuclear receptor binding
.N-acetyltransferase activity
  + 4 more...
.nBAF complex
.npBAF complex
.protein complex
  + 6 more...
54 EBI-2130429,EBI-726510 LENG1  
  .N/A .N/A .N/A
55 EBI-2130429,EBI-2514791 HAUS1  
  .cell division
.centrosome organization
.spindle assembly
.mitotic nuclear division
.N/A .HAUS complex
.microtubule
.centrosome
  + 2 more...
56 EBI-2130429,EBI-746259 OTUB2  
  .protein K48-linked deubiquitination
.protein K63-linked deubiquitination
.protein K11-linked deubiquitination
.protein deubiquitination
.ubiquitin-specific protease activity .nucleus
57 EBI-2130429,EBI-2556091 WDR34  
  .organelle organization .N/A .ciliary tip
.primary cilium
.ciliary basal body
  + 3 more...
58 EBI-2130429,EBI-1765605 THOC1  
  .negative regulation of DNA damage checkpoint
.negative regulation of isotype switching to IgA isotypes
.viral mRNA export from host cell nucleus
  + 11 more...
.RNA binding
.DNA binding
.intercellular bridge
.nuclear speck
.nuclear matrix
  + 6 more...
59 EBI-2130429,EBI-740086 DCUN1D1  
  .N/A .N/A .nucleus
.ubiquitin ligase complex
60 EBI-2130429,EBI-748884 LIN37  
  .regulation of cell cycle
.mitotic cell cycle
.G2/M transition of mitotic cell cycle
.N/A .transcriptional repressor complex
.nucleoplasm
61 EBI-2130429,EBI-747719 SNF8  
  .regulation of viral budding via host ESCRT complex
.positive regulation of exosomal secretion
.regulation of protein complex stability
  + 11 more...
.protein N-terminus binding
.protein homodimerization activity
.channel regulator activity
  + 2 more...
.extracellular exosome
.recycling endosome
.perinuclear region of cytoplasm
  + 10 more...
62 EBI-2130429,EBI-741158 WDYHV1  
  .cellular protein modification process .protein-N-terminal glutamine amidohydrolase activity .cytosol
.nucleus
63 EBI-2130429,EBI-6165879 NGLY1  
  .glycoprotein catabolic process .metal ion binding
.peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity
.cytoplasm
64 EBI-2130429,EBI-740773 RBM41  
  .N/A .RNA binding
.nucleotide binding
.N/A
65 EBI-2130429,EBI-6427977 ZNF587  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
66 EBI-2130429,EBI-1752811 FAM110A  
  .N/A .N/A .microtubule organizing center
.cytoplasm
.spindle pole
67 EBI-2130429,EBI-2125614 KIFC3  
  .epithelial cell-cell adhesion
.zonula adherens maintenance
.metabolic process
  + 3 more...
.ATPase activity
.ATP binding
.microtubule motor activity
.extracellular exosome
.cytoplasmic vesicle membrane
.zonula adherens
  + 4 more...
68 EBI-2130429,EBI-748391 SCNM1  
  .RNA splicing
.mRNA processing
.metal ion binding
.enzyme binding
.nuclear speck
.nucleolus
.nucleus
69 EBI-2130429,EBI-2817707 C1QTNF2  
  .protein heterotrimerization
.protein homooligomerization
.positive regulation of glucose import
  + 3 more...
.N/A .extracellular space
.collagen trimer
70 EBI-2130429,EBI-744099 ENKD1  
  .N/A .N/A .microtubule cytoskeleton
.cytoplasmic microtubule
71 EBI-2130429,EBI-751319 CARD9  
  .nucleotide-binding oligomerization domain containing signaling pathway
.defense response to virus
.defense response to Gram-positive bacterium
  + 17 more...
.CARD domain binding
.protein homodimerization activity
.plasma membrane
.cytosol
.cytoplasm
72 EBI-2130429,EBI-741626 FAM124B  
  .N/A .N/A .N/A
73 EBI-2130429,EBI-2836158 C12orf49  
  .N/A .N/A .extracellular region
74 EBI-2130429,EBI-399266 MEAF6  
  .histone H3-K14 acetylation
.histone H4-K12 acetylation
.histone H4-K8 acetylation
  + 5 more...
.N/A .MOZ/MORF histone acetyltransferase complex
.NuA4 histone acetyltransferase complex
.centrosome
  + 3 more...
75 EBI-2130429,EBI-371876 EXOSC5  
  .RNA phosphodiester bond hydrolysis, exonucleolytic
.polyadenylation-dependent snoRNA 3'-end processing
.nuclear mRNA surveillance
  + 10 more...
.RNA binding
.3'-5'-exoribonuclease activity
.transcriptionally active chromatin
.cytosol
.cytoplasm
  + 5 more...
76 EBI-2130429,EBI-8787464 TBC1D22B  
  .N/A .GTPase activator activity .N/A
77 EBI-2130429,EBI-749261 CCDC87  
  .cytokinesis
.microtubule cytoskeleton organization
.N/A .N/A
78 EBI-2130429,EBI-8643161 C1orf109  
  .N/A .N/A .N/A
79 EBI-2130429,EBI-742688 SPG21  
  .antigen receptor-mediated signaling pathway .CD4 receptor binding .trans-Golgi network transport vesicle
.endosome membrane
.cytosol
  + 3 more...
80 EBI-2130429,EBI-743428 RCOR3  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.chromatin binding
.DNA binding
.nucleus
81 EBI-2130429,EBI-913954 RABGEF1  
  .negative regulation of Kit signaling pathway
.negative regulation of interleukin-6 secretion
.regulation of Fc receptor mediated stimulatory signaling pathway
  + 9 more...
.Rab GTPase binding
.Rab guanyl-nucleotide exchange factor activity
.zinc ion binding
  + 2 more...
.recycling endosome
.vesicle
.early endosome
82 EBI-2130429,EBI-10172526 MID2  
  .negative regulation of viral release from host cell
.positive regulation of NF-kappaB transcription factor activity
.positive regulation of sequence-specific DNA binding transcription factor activity
  + 6 more...
.phosphoprotein binding
.protein heterodimerization activity
.protein homodimerization activity
  + 3 more...
.extracellular exosome
.microtubule
.cytoplasm
83 EBI-2130429,EBI-311356 MYO5B  
  .transmembrane transport
.endosome localization
.vesicle-mediated transport
  + 4 more...
.Rab GTPase binding
.ATP binding
.microfilament motor activity
.extracellular exosome
.apical cortex
.protein complex
  + 2 more...
84 EBI-2130429,EBI-2212028 SSX2IP  
  .regulation of cell motility
.centrosome organization
.cilium assembly
  + 3 more...
.N/A .protein complex
.ciliary basal body
.centriolar satellite
  + 3 more...
85 EBI-2130429,EBI-347416 LSM2  
  .exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
.gene expression
.RNA splicing
  + 2 more...
.poly(A) RNA binding
.Ral GTPase binding
.U6 snRNA binding
.catalytic step 2 spliceosome
.cytosol
.nucleoplasm
86 EBI-2130429,EBI-2321769 CHCHD2  
  .regulation of cellular response to hypoxia
.positive regulation of transcription from RNA polymerase II promoter
.transcription, DNA-templated
.sequence-specific DNA binding
.transcription factor binding
.mitochondrion
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
bone55
eye9
kidney4
larynx42
muscle112
ovary9
prostate10
testis9
thyroid322
tonsil58
Health State
TissuesTPM*
normal12
chondrosarcoma48
ovarian tumor13
Developmental Stage
TissuesTPM*
adult14
fetus3
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adrenal gland2.4
cerebral cortex1.2
duodenum2.6
esophagus5.2
heart muscle78.7
prostate7.1
small intestine1.4
testis9.6
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*606474, gene) Ring finger protein 30; RNF30OMIM


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