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> Protein (NX_Q9BYW2)
Protein (NX_Q9BYW2)
Protein
Gene SymbolSETD2 to neXtProt (NX_Q9BYW2)
DescriptionHistone-lysine N-methyltransferase SETD2
Chromosome3
Location3p21.31 (47057919 ~ 47205457) to Ensembl
Sequene Features : Isoforms 3, Variants 317, PTMs 23 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.histone H3-K36 trimethylation
.coronary vasculature morphogenesis
.embryonic placenta morphogenesis
  + 15 more...
.histone-lysine N-methyltransferase activity .chromosome
.nucleoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 317 23
2014-09-19protein level
3 256 23
2014-05-27protein level
3 256 23
2014-02-25protein level
3 245 23
2013-12-09protein level
3 202 23
2013-11-01protein level
3 190 22
2013-09-12protein level
3 190 22
2013-08-17protein level
3 188 22
2013-07-15protein level
3 112 22
2013-06-11protein level
3 112 22
2013-02-12protein level
3 54 59
2012-12-20protein level
3 62 59
2012-10-30protein level
3 78 59
2012-10-07protein level
3 78 23
2012-08-24protein level
3 57 23
2012-07-28protein level
3 57 23
2012-06-08protein level
3 84 23
2012-05-07protein level
3 80 23
2012-04-10protein level
3 80 23
2012-01-13protein level
3 57 23
2011-12-20protein level
3 57 23
2011-11-11protein level
3 57 20
2011-08-23protein level
3 57 20
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9BYW2-1
27 76 0 287417.5161
NX_Q9BYW2-2
0 76 0 192222.2568
NX_Q9BYW2-3
0 68 0 175872.329
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-945869,EBI-466029 HTT  
  .negative regulation of extrinsic apoptotic signaling pathway
.iron ion homeostasis
.L-glutamate import
  + 38 more...
.diazepam binding
.beta-tubulin binding
.dynein intermediate chain binding
  + 6 more...
.protein complex
.cytoplasmic vesicle membrane
.dendrite
  + 11 more...
2 EBI-945869,EBI-347161 SMAD3  
  .positive regulation of extracellular matrix assembly
.activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
.extrinsic apoptotic signaling pathway
  + 73 more...
.R-SMAD binding
.co-SMAD binding
.transcription regulatory region DNA binding
  + 21 more...
.SMAD2-SMAD3 protein complex
.SMAD protein complex
.receptor complex
  + 8 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
ascites25
blood40
bone83
bone marrow41
brain31
cervix20
connective tissue33
embryonic tissue70
eye38
heart44
intestine56
kidney90
liver87
lung158
lymph node122
mammary gland33
mouth15
muscle94
nerve128
ovary88
pancreas65
pharynx73
placenta21
prostate116
skin66
spleen93
stomach73
testis45
thymus37
thyroid42
tonsil58
trachea77
uterus116
Health State
TissuesTPM*
normal63
breast (mammary gland) tumor21
cervical tumor28
chondrosarcoma132
colorectal tumor35
gastrointestinal tumor59
germ cell tumor83
head and neck tumor14
kidney tumor72
leukemia10
liver tumor135
lung tumor214
lymphoma55
non-neoplasia41
ovarian tumor105
pancreatic tumor28
primitive neuroectodermal tumor of the CNS7
prostate cancer28
skin tumor95
soft tissue/muscle tissue tumor55
uterine tumor166
Developmental Stage
TissuesTPM*
adult69
embryoid body142
blastocyst32
fetus73
infant42
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue12.3
adrenal gland12.6
appendix16.6
bone marrow24.8
cerebral cortex10.7
colon16
duodenum14.9
esophagus13.3
gallbladder14.4
heart muscle8
kidney16.9
liver11.7
lung14
lymph node21.7
ovary20.2
pancreas9.2
placenta14.9
prostate15.1
salivary gland11.5
skin15.5
small intestine15
spleen17
stomach14.8
testis21.7
thyroid gland21.5
urinary bladder15.5
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
breastLow
bronchusLow
cerebellumLow
cerebral cortexMedium
cervix, uterineMedium
colonMedium
duodenumMedium
endometrium 1Low
endometrium 2Low
epididymisMedium
esophagusMedium
fallopian tubeMedium
gallbladderMedium
hippocampusLow
kidneyLow
lateral ventricleLow
lungLow
lymph nodeMedium
nasopharynxLow
oral mucosaMedium
ovaryMedium
pancreasLow
placentaMedium
rectumMedium
seminal vesicleMedium
skeletal muscleLow
skin 1Medium
skin 2Medium
small intestineMedium
smooth muscleLow
soft tissue 2Low
stomach 1Low
stomach 2Medium
testisMedium
thyroid glandMedium
tonsilMedium
urinary bladderMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#144700, phenotype) Renal cell carcinoma, nonpapillary; RCCOMIM
2(*612778, gene) Set domain-containing protein 2; SETD2OMIM
3clear cell renal carcinomaCGP


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